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Nitrogenous bases covalently linked to a sugar with and without phosphate groups; used for synthesis, cell signaling, and as cofactors in enzymatic reactions; includes pyrimidine, purine, pyridine, flavin, pyrrolopyrimidine, and triazole varieties.
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Adenosine dialdehyde is a purine nucleoside analogue that potently inhibits S-adenosylhomocysteine hydrolase (SAHH). It is used in biochemical assays and cancer research to study methylation-dependent pathways and can be supplied as a 10 mM solution in DMSO or as solid analytical standards.
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L-Guanosine is the L-enantiomer of the purine nucleoside guanosine, provided as a research-grade small molecule for biochemical and antiviral studies and for preparing supramolecular hydrogels. The material is characterized with defined physicochemical properties and recommended storage and handling conditions.
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7-Deaza-ATP is a chemically modified ATP analog wherein the nitrogen atom at position 7 of the adenine ring is replaced by a carbon atom This structural alteration modulates its interactions with enzymes and nucleic acid-binding proteins As a nucleotide analog 7-Deaza-ATP can be incorporated into DNA and RNA strands thereby influencing polymerase enzyme activity and subsequently affecting nucleotide synthesis replication and repair processes Due to these properties this molecule is applied in investigating nucleotide-protein binding specificity and the catalytic mechanisms of enzymes facilitating research towards nucleotide-targeted therapeutic strategies
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GTP-Binding Protein Fragment G alpha is a peptide fragment derived from the amino-terminal region of the alpha subunit of GTP-binding proteins It is designed to aid in elucidating the mechanisms of membrane association and -subunit interactions in cell signaling pathways GTP-Binding Protein Fragment G alpha exerts its biological activity by retaining membrane-binding properties independent of the nucleotide-binding state anchoring the protein to the cytoplasmic membrane surface This peptide fragment serves as an experimental tool to study membrane-association mechanisms and signal transduction pathways in biochemical and biomedical research Based on these properties GTP-Binding Protein Fragment G alpha holds research potential in investigating the molecular basis of G protein-mediated signal transduction and protein-membrane interactions
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Guanosine-15N5 is an isotopically labeled form of Guanosine, where 15N (nitrogen-15) replaces the natural nitrogen atoms in the molecule. Guanosine is a purine nucleoside, formed by the attachment of guanine to a ribose sugar via a β-N9-glycosidic bond. This compound is primarily intended for research purposes.
15N labeled compound
Purine nucleoside
Formed from guanine and ribose
Possesses anti-HSV activity
Suitable for research applications
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Adenosine-13C10,15N5 is a labeled adenosine, an endogenous purine nucleoside that acts as an important homeostatic regulator of physiological function and an anti-arrhythmic agent.
Labeled adenosine
Endogenous purine nucleoside
Acts as an important homeostatic regulator of physiological function
Functions as an anti-arrhythmic agent
Modulates various physiological processes
Activates G protein-coupled receptors (GPCRs), including adenosine receptors (ARs)
Involved in energy metabolism
Used in research for various diseases
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Adenosine 2',3'-cyclic phosphate sodium is a 2',3'-cyclic purine nucleotide. It is deaminated by adenosine deaminase and can be degraded to 2'-AMP and 3'-AMP.
Efficiently hydrolyzed by the monocations of alkylenediamines at pH 9.0, 50°C.
Deaminated by adenosine deaminase from Drosophila larvae.
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Adenosine amine congener (ADAC) is a selective A1 adenosine receptor agonist. It can ameliorate noise- and cisplatin-induced cochlear injury and demonstrates neuroprotective effects.
Selective A1 adenosine receptor agonist
Ameliorates noise- and cisplatin-induced cochlear injury
Has neuroprotective effects
Reduces oxidative stress in noise-exposed cochlea
Protects sensory hair cells
Reduces cisplatin-induced apoptosis in cochlear tissues
Inhibits glutamate release via presynaptic A1 receptors
Inhibits voltage-gated Ca2+ channels
Mitigates noise-induced hearing loss in a dose- and time-dependent manner
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Rp-cAMPS sodium salt is a cAMP analog that competitively antagonizes cAMP-dependent protein kinase A (PKA) I and II and is resistant to hydrolysis by phosphodiesterases, intended for biochemical and cell signaling research applications.
High purity (≈99.7%) suitable for biochemical assays.
Molecular formula C10H11N5NaO5PS and molecular weight 367.25 g/mol.
Resistant to hydrolysis by phosphodiesterases.
Reported Ki values ~6.05 μM (PKA I) and ~9.75 μM (PKA II).
Solid, white to pink appearance; available as solid or solution (10 mM in DMSO).
Storage: -20°C sealed; in solvent -80°C (6 months) or -20°C (1 month).
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