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CK-666 is a cell-permeable actin-related protein Arp2/3 complex inhibitor with an IC50 of 12 μM. It binds to the Arp2/3 complex, stabilizing its inactive state and blocking the movement of the Arp2 and Arp3 subunits into the activated filament-like conformation.
Cell-permeable
Arp2/3 complex inhibitor
Stabilizes the inactive state of the Arp2/3 complex
Blocks movement of Arp2 and Arp3 subunits into activated filament-like conformation
Significantly reduces filopodia on cell surface of treated trabecular meshwork (TM) cells.
Reduces uptake of S-EMs by VSMCs.
Inhibits S-EMs-induced proliferation of VSMCs.
Inhibits S-EMs-induced migration of VSMCs.
Reduces F-actin polymerization in E15.5 fetal mice.
Reduces F-actin/G-actin ratio in doxycycline-treated iPSC-derived neurons.
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
CK-666 is an inhibitor of the actin-related protein 2/3 (Arp2/3) complex with IC50 of 17 M and 5 M for BtArp2/3 complex and SpArp2/3 complex respectively
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Tetrahydrofuran-d8 may be used as a solvent in the synthesis of deuteriotris[bis(trimethylsilyl)amido]thorium and deuteriotris[bis(trimethylsiiyl)amido]uranium.
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