Monosaccharides
Medchemexpress LLC Lometrexol disodium | 120408-07-3 | 98.0% | C21H23N5Na2O6 | 1 MG
Lometrexol disodium is an antipurine antifolate that inhibits glycinamide ribonucleotide formyltransferase (GARFT) and human Serine hydroxymethyltransferase1/2 (hSHMT1/2). This leads to the inhibition of de novo purine synthesis, causing abnormal cell proliferation, apoptosis, and cell cycle arrest, thus exhibiting anticancer activity.
- Inhibits purine synthesis.
- Induces cell apoptosis.
- Causes cell cycle arrest.
- Demonstrates anticancer properties.
Medchemexpress LLC Piperaquine phosphate | 85547-56-4 | 98.6% | 100 MG
Piperaquine phosphate is a bisquinoline antimalarial agent. It can be utilized in antimalarial research in conjunction with Artemisinin.
- Acts as a bisquinoline antimalarial agent
- Used in antimalarial research with artemisinin
- Reduces parasitemia in mice
- Extends median survival time in animal models with Plasmodium berghei parasites
Medchemexpress LLC Piperaquine (phosphate) | 85547-56-4 | 98.6% | 25 MG
Piperaquine phosphate is a bisquinoline antimalarial agent. It can be used in antimalarial research in combination with Artemisinin.
- Bisquinoline antimalarial agent.
- Can be used in antimalarial research in combination with Artemisinin.
- In vivo, Piperaquine (10-90 mg/kg; a single i.p.) decreases parasitemia in mice.
- At a dose of 90 mg/kg, it resulted in stable body weights and active mice throughout the study.
- Purity: 98.62%.
Cambridge Isotope Laboratories D-Glucose-6-phosphate disodium salt hydrate (unlabeled) 0 1 mg
D-Glucose-6-phosphate disodium salt hydrate (unlabeled) 0 1 mg
Medchemexpress LLC Cyclic GMP-AMP (disodium); 3',3'-cGAMP (disodium) | 2407516-83-8 | 98.47% | 718.37 | 1 MG
cGAMP disodium is an endogenous second messenger that triggers interferon production in response to cytosolic DNA. It activates stimulator of interferon genes (STING), leading to a signaling cascade that produces type I interferons and other immune mediators. This product is suitable for various research applications.
- Promotes antigen-specific proliferation capacity of spleen cells
- Directly activates murine and human dendritic cells in vitro
- Increases transcription of IFNB1 in stimulated fibroblasts
- Induces an antiviral state and type I IFN secretion by activating ER-resident receptor STING
Medchemexpress LLC K-Ras ligand-linker conjugate 4 | 2378261-83-5 | 98.8% | C35H51N7O8 | 10MG
K-Ras ligand-Linker Conjugate 4 is a research-grade ligand-linker conjugate designed for K-Ras targeting and PROTAC development. Supplied as an oil or as a 10 mM solution in ethanol, it is intended for laboratory research use only.
- High purity (98.76%).
- Available in multiple pack sizes, including 10 mg and solution format.
- Appearance: oil; soluble in ethanol for solution preparations.
- Storage: -20°C under nitrogen; in solvent: -80°C for 6 months, -20°C for 1 month.
- Documentation available: datasheet, certificate of analysis, and safety data sheet.
- Suitable for biochemical and chemical biology research involving ligand conjugation and PROTAC studies.
Medchemexpress LLC Pemetrexed (disodium heptahydrate) | 357166-29-1 | MFCD09029394 | 99.9% | 597.5 g/mol | C20H33N5Na2O13 | 50 MG
Pemetrexed disodium heptahydrate is the disodium heptahydrate salt of pemetrexed, a multitargeted antifolate that interferes with folate-dependent enzymes required for nucleotide biosynthesis. Supplied for research use, it is intended for biochemical and cell-based studies of antitumor activity and folate metabolism.
- Multitargeted antifolate activity inhibiting TS, DHFR, and GARFT.
- Heptahydrate form for defined hydration state and reproducibility.
- High purity suitable for research (99.9%).
- Provided in small research quantities for laboratory experiments.
- Molecular weight approximately 597.5 g/mol for formulation calculations.
Apexbio Technology LLC Phosphatase Inhibitor Cocktail (1 Tube, EDTA-Free, 100X)(Synonyms: Phosphatase Inhibitor Cocktail, Phosphatase Inhibitor Mix, Phosphatase Inhibitor Set), 50X1ml.
Phosphatase Inhibitor Cocktail (1 Tube EDTA-Free 100X) provides comprehensive inhibition of various phosphatases including acid and alkaline phosphatases serine/threonine phosphatases (e g PP1 PP2A PP2B) and protein tyrosine phosphatases (PTPs) By suppressing phosphatase enzymatic activities it preserves phosphorylation states of proteins in lysates from mammalian plant yeast insect or bacterial samples ensuring more accurate downstream analysis It is applicable in protein lysate preparations immunoprecipitations nuclear extracts and processing of fixed tissues (e g FFPE) to maintain phosphorylation modifications
Medchemexpress LLC Fludarabine (phosphate) | 75607-67-9 | 99.8% | 365.21 | 10 MG
Fludarabine phosphate is an analogue of adenosine and deoxyadenosine, which is able to compete with dATP for incorporation into DNA and inhibit DNA synthesis. This product is for research use only.
- Mimics natural building blocks of DNA
- Interferes with normal DNA synthesis
- Inhibits DNA synthesis
- Shows anticancer activity against various human cell lines
- Significantly reduces cell viability in a dose-dependent manner in vitro
- Leads to complete regressions of tumors and cures in mice in vivo