Monosaccharides
Medchemexpress LLC NSC-87877 (disodium) | 56932-43-5 | 98.0% | 503.42 | 50 MG
NSC-87877 disodium is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases, with IC50 values of 0.318 μM and 0.355 μM for Shp2 and Shp1, respectively. It also inhibits dual-specificity phosphatase 26 (DUSP26).
- Potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases
- Inhibits dual-specificity phosphatase 26 (DUSP26)
- Inhibits DUSP26 function in NB cell lines
- Results in increased p53 phosphorylation and activation
- Possesses excellent anti-neuroblastoma activity in vivo
Medchemexpress LLC Sitagliptin (phosphate) | 654671-78-0 | 99.6% | 505.31 | 1 ML
Sitagliptin (MK-0431) phosphate is an orally active and highly selective DPP4 inhibitor with an IC50 value of 19 nM. It blocks the degradation of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) by competing inhibition mechanism (Kᵢ = 1 nM), thereby increasing the level of active incretin. Sitagliptin phosphate can also directly stimulate the secretion of GLP-1 by intestinal L cells by activating the cAMP/PKA and ERK1/2 pathways, independent of DPP-4. It shows protective effects on pancreatic islet grafts in type 1 diabetes models and can be used for the study of type 1 and type 2 diabetes.
- Orally active and highly selective DPP4 inhibitor
- Blocks degradation of GLP-1 and GIP
- Increases active incretin levels
- Directly stimulates GLP-1 secretion
- Protective effects on pancreatic islet grafts
- Useful for type 1 and type 2 diabetes research
Medchemexpress LLC K-Ras ligand-linker conjugate 6 | 2378261-89-1 | C42H60N8O7 | 10MG
K-Ras ligand-Linker Conjugate 6 is a small-molecule ligand-linker designed as an intermediate for targeted protein degradation research. It links a K-Ras-binding ligand to a PROTAC linker to enable synthesis of K-Ras degraders for cellular degradation studies.
- High purity confirmed by HPLC (98.9%).
- Characterized by mass spectrometry consistent with structure.
- Molecular formula C42H60N8O7 and molecular weight 788.98 g/mol.
- Suitable for PROTAC synthesis and K-Ras degrader development.
- Available in multiple small-scale pack sizes (5 mg-100 mg) for research use.
Selleck Chemical LLC b-D-Glucose pentaacetate
-D-Glucose pentaacetate is an enantiomer of D-glucose pentaacetate
Medchemexpress LLC Penta-O-acetyl-β-D-glucopyranose | 604-69-3 | 98.0% | 390.34 | 100 G
β-D-Glucose pentaacetate is a glucose derivative primarily utilized for investigating the mechanism of insulin secretion. It acts as an insulinotropic agent and is slightly less potent than α-D-Glucose Pentaacetate in stimulating insulin secretion.
- A glucose derivative.
- Primarily used to explore insulin secretion mechanisms.
- Acts as an insulinotropic agent.
- Shows cytotoxicity against various human cell lines at high concentrations (> 200 μM).