Sugar acids and derivatives
Sigma Aldrich Fine Chemicals Biosciences 3dGROTM Colon Intestinal O
Patient derived organoids (PDOs) are novel in vitro 3D cell models that preserve original tissue physiology and molecular pathology thus representing a clinically-relevant alternative to traditional 2D cell lines and an effective tool to refine and reduce animal models. PDOs can be derived from adult patient biopsies or resected tissues containing native LGR5 stem cell populations and cultured within an ECM-rich substrate using specialized organoid media such as L-WRN conditioned media. Adult tissue derived organoids are phenotypically and genetically stable in long term culture presenting more mature phenotypes compared to iPSC-derived organoids. Importantly PDOs have shown to be able to predict patient clinical responses to chemotherapeutics.We are now offering a comprehensive biobank of highly characterized tissue-derived human gastrointestinal organoids from normal and diseased patients. The intestinal organoid biobank contains over 50 highly characterized intestinal organoids f
![Alkali Scientific Luria Broth, High Salt Formula, Powder [Miller's LB Broth], 100 Grams](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000660073.jpg-250.jpg)
Alkali Scientific Luria Broth, High Salt Formula, Powder [Miller's LB Broth], 100 Grams
Luria Broth, High Salt Formula (Miller's LB Broth), 100 Grams, is a bacterial growth medium enriched with high levels of sodium chloride, making it ideal for growing salt-tolerant bacteria or for experiments requiring osmotic pressure variation. Commonly used in microbial research, particularly for bacteria that need a higher concentration of salt, this medium is often used in gene expression and transformation studies.
Medchemexpress LLC Integrin alpha V bet 100ug | 100ug
Integrin V beta 5 proteins specifically the -V (ITGAV) subunit are multifunctional receptors for ligands such as vitronectin and fibronectin and recognize RGD sequences ITGAV ITGB3 binds fractalkine and acts as a coreceptor in CX3CR1-dependent signaling Integrin alpha V beta 3 Protein Human (HEK293 His-Avi) is a recombinant protein dimer complex containing human-derived Integrin alpha V beta 3 protein expressed by HEK293 with C-His C-Avi labeled tag Integrin alpha V beta 3 Protein Human (HEK293 His-Avi) has molecular weight of 85-140 kDa
Apexbio Technology LLC HyperTrap Heparin FF Column 5ml
HyperTrap Heparin FF Column is an affinity chromatography medium designed for the purification of heparin-binding biomolecules The column exploits the strong ionic and specific interactions between immobilized heparin and target proteins such as growth factors coagulation factors and certain enzymes enabling selective retention and efficient separation from complex biological mixtures This tool is widely utilized in the isolation and characterization of heparin-binding proteins investigation of protein glycosaminoglycan interactions and purification of bioactive factors for downstream functional assays and structural analyses
![Apexbio Technology LLC heparin cofactor II precursor fragment [Homo sapiens] 5mg](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000097081.png-250.jpg)
Apexbio Technology LLC heparin cofactor II precursor fragment [Homo sapiens] 5mg
Heparin cofactor II precursor fragment is a thrombin inhibitor peptide targeting human thrombin (factor IIa) It is designed to inhibit thrombin activity thereby modulating blood coagulation pathways Heparin cofactor II precursor fragment exerts its biological activity primarily through serine protease inhibition facilitated in the presence of heparin or dermatan sulfate Based on these pharmacological properties heparin cofactor II precursor fragment holds research potential in investigating thrombin inhibition mechanisms blood coagulation pathways and conditions associated with altered coagulation such as heparin cofactor II deficiency and hypercoagulability disorders
Medchemexpress LLC Lucifer yellow CH dipotassium salt | 71206-95-6 | MFCD00013445 | 95.0% | 521.57 g/mol | C13H9K2N5O9S2 | 25 MG
Lucifer Yellow CH dipotassium salt is a water-soluble fluorescent tracer dye used for neuronal morphology studies, gap junction detection, and selective cell labeling. Supplied as a stable powder, it is suitable for microscopy and electrophysiology applications where strong, reliable fluorescence is required. The material's solubility and reactive functional groups make it adaptable for fixation and conjugation workflows.
- Water-soluble fluorescent tracer suitable for neuronal tracing.
- High fluorescence intensity for clear imaging.
- Reactive hydrazide groups enable conjugation with aldehydes.
- Supplied as a stable powder for easy storage and handling.
- Available in small research-sized quantities (e.g., 25 mg).
Medchemexpress LLC 4-Methylumbelliferyl phosphate | 3368-04-5 | 99.8% | 256.15 | 1 ML
4-Methylumbelliferyl phosphate (4-MUP) is an anionic organophosphate and a fluorogenic substrate for both acid and alkaline phosphatase. It is also recognized as a nerve agent simulant, primarily for research use.
- Anionic organophosphate
- Fluorogenic substrate for acid and alkaline phosphatase
- Nerve agent simulant
- Used in serum acid phosphatase assays
Medchemexpress LLC Dodecanedioic acid-d4 | 97543-02-7 | 234.33 | 10 MG
Dodecanedioic acid-d4 is the deuterium labeled version of Dodecanedioic acid. Dodecanedioic acid is an orally active straight-chain dicarboxylic acid that acts as an alternative energy substrate. It can be rapidly oxidized during exercise, reducing muscle fatigue without stimulating insulin secretion, and also exhibits blood glucose-lowering activity in non-insulin-dependent diabetes mellitus.
- Deuterium labeled compound for quantitative tracing during drug development.
- Reduces muscle fatigue during exercise.
- Exhibits blood glucose-lowering activity.
Apexbio Technology LLC Beta-Lapachone 4707-32-8 10mg
Beta-Lapachone (CAS 4707-32-8) is a small molecule inhibitor of DNA topoisomerase I In DNA unwinding assays beta-Lapachone suppresses topoisomerase I-mediated DNA relaxation at concentrations as low as 1 M without inhibiting topoisomerase II or inducing topoisomerase I-dependent DNA cleavage It exhibits broad cytotoxicity against human cancer cell lines such as AD2780s HT-29 DLD G480 and MCF-7 with IC50 values ranging from 2 to 5 M The compound induces cell death through cytochrome c release triggering both apoptosis and necrosis and affects cell cycle progression causing S-phase and G2/M arrest in different carcinoma cell models Beta-Lapachone is widely utilized in studies investigating topoisomerase I inhibition cancer cell cytotoxicity and cell cycle regulation
Medchemexpress LLC Arnicolide D | 34532-68-8 | 10 MG
Arnicolide D is a sesquiterpene lactone isolated from Centipeda minima. It demonstrates cytotoxicity against tumor cells, inducing cell cycle arrest, apoptosis, and oncosis. Arnicolide D exhibits anti-tumor activity.
- Antitumor agent: Is cytotoxic to tumor cells and has anti-tumor activity.
- Induces cell cycle arrest and apoptosis in nasopharyngeal carcinoma cells by activating the caspase signaling pathway and inhibiting the PI3K/AKT/mTOR and STAT3 signaling pathways.
- Induces endoplasmic reticulum stress-mediated and ROS-dependent oncosis in hepatocellular carcinoma cells via ATF4 and CHOP.
- Demonstrates anti-melanoma effects and inhibits the NF-κB pathway in an in vivo B16F10 allograft mouse model.
- High purity of 99.69%.
- Solid, white to off-white appearance.
Medchemexpress LLC D-Moses (D-45) | 2084850-77-9 | >98.0% | 360.46 g/mol | C21H24N6 | 10 MG
D-Moses (D-45) is the D-enantiomer of L-Moses and is provided as an inactive control compound for studies of the p300/CBP-associated factor (PCAF) bromodomain. It is intended for research use and is supplied as a powder with reported high purity for biochemical and cellular assays (CAS 2084850-77-9).
- Inactive enantiomer control for bromodomain assays.
- Suitable for biochemical and cell-based experiments.
- Reported purity greater than 98%.
- Available in small, precise milligram sizes for screening.
- Powder form with limited aqueous solubility; soluble in common organic solvents.
![Alkali Scientific MUG [4 Methylumbelliferyl β D glucuronide Trihydrate], 1 G](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000661658.jpg-250.jpg)
Alkali Scientific MUG [4 Methylumbelliferyl β D glucuronide Trihydrate], 1 G
Methylumbelliferyl β-D Glucuronide Trihydrate, 1 g is a highly sensitive biochemical reagent used in the detection and study of glucuronidase enzyme activity. The substrate is hydrolyzed by glucuronidases to produce a fluorescent product that can be quantified, making it valuable for enzyme assays in biochemical research. It is used in clinical diagnostics, microbiological testing, and enzyme kinetics studies to measure glucuronidase activity. The high purity and sensitivity of this reagent make it suitable for detecting low enzyme concentrations, ensuring precise and reproducible results in applications that require accurate enzyme activity quantification.