Sugar acids and derivatives
Medchemexpress LLC 2,6-dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide | 1258292-64-6 | 99.8% | 1 ML
GDC-046 (2,6-dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide) is a potent, selective, orally bioavailable TYK2 inhibitor with reported Ki values of 4.8 nM (TYK2), 0.7 nM (JAK1), 0.7 nM (JAK2), and 0.4 nM (JAK3). Supplied for research use, available as a 10 mM solution in DMSO (1 mL) or as solid material.
- Potent, selective TYK2 inhibitor with low-nanomolar activity against JAK family kinases.
- Molecular weight 350.2 g/mol; formula C16H13Cl2N3O2.
- CAS 1258292-64-6; purity 99.8%.
- Physical form solid, off-white to yellow; also supplied as 10 mM solution in DMSO (1 mL).
- Solubility in DMSO 62.5 mg/mL (178.47 mM); ultrasonic assistance recommended.
- Storage: solid at 4 °C; in solvent store at -80 °C (up to 6 months) or -20 °C (up to 1 month); protect from light.
Medchemexpress LLC Interferon alpha/beta receptor 1 Antibody (YA3833) | Predicted band size: 64 kDa; Observed band size: 110-130 kDa | 50 UL
The Interferon alpha/beta receptor 1 Antibody (YA3833) is a mouse-derived, non-conjugated IgG1 monoclonal antibody that targets Interferon alpha/beta receptor 1. This antibody is intended for research use only. Interferon alpha/beta receptor 1 (IFNAR1), in conjunction with IFNAR2, forms the heterodimeric receptor crucial for type I interferon signaling. Binding of type I interferons initiates the JAK-STAT signaling cascade, which leads to the transcriptional regulation of interferon-regulated genes that mediate the interferon response.
- Host: Mouse
- Clonality: Monoclonal antibody
- Species reactivity: Human, mouse
- Conjugation: Non-conjugated
- Isotype: IgG1
- Appearance: Liquid
- Formulation: Supplied in PBS with 0.05% sodium azide
- Purity: Affinity purified
- Storage: Stored at -20°C for 1 year. Avoid repeated freeze/thaw cycles.
- Applications: WB, IHC-P, FC, ELISA
Apexbio Technology LLC Beta-Amyloid (1-11) 190436-05-6 25mg
Beta-Amyloid (1-11) (CAS 190436-05-6) is a synthetic peptide fragment derived from the N-terminus of the amyloid precursor protein comprising the amino acid sequence H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-OH This peptide represents a portion of the beta-amyloid (A ) sequence implicated in amyloidogenic pathways associated with neurodegenerative processes particularly Alzheimer s disease Beta-Amyloid (1-11) is utilized in research to investigate amyloid aggregation dynamics immunogenic epitope mapping within the A region and the biochemical properties of amyloidogenic peptides It serves as a molecular tool in studies examining the early stages of A processing clearance and interactions with cellular components
Medchemexpress LLC D-Arabinopyranose | 28697-53-2 | 25 MG
D-Arabinopyranose is a monosaccharide and an analytical standard intended for research and analytical applications. It has been shown to exhibit strong growth inhibition against Caenorhabditis elegans with an IC50 of 7.5 mM.
- Analytical standard for research and analytical applications
- Exhibits strong growth inhibition against Caenorhabditis elegans
- Commonly used in qualitative, quantitative, and methodological research experiments
- Suitable for techniques such as HPLC, GC, and MS
- Reference standard supplied for assay
Medchemexpress LLC 4-Methylumbelliferyl 1g
4-Methylumbelliferyl octanoate is a octoate 4-Methylumbelliferyl octanoate can be used as a s ubstrate of hog pancreatic lipase[1]
![Medchemexpress LLC Sar-[D-Phe8]-des-Arg9-bradykinin | 126959-88-4 | MFCD05662308 | 100.0% | 975.10 | C47H66N12O11 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000244662.png-250.jpg)
Medchemexpress LLC Sar-[D-Phe8]-des-Arg9-bradykinin | 126959-88-4 | MFCD05662308 | 100.0% | 975.10 | C47H66N12O11 | 25 MG
Sar-[D-Phe8]-des-Arg9-bradykinin is a synthetic peptide agonist of the bradykinin B1 receptor used in pharmacological research to study receptor activation and contractile responses. It is supplied as a white to off-white solid with high purity and a defined amino acid sequence.
- High purity suitable for analytical and biological assays.
- Molecular weight 975.10 and formula C47H66N12O11.
- Sequence: {Sar}-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe.
- Stable as powder when stored sealed at -80°C (2 years) or -20°C (1 year).
- Available in multiple sizes, including 25 MG.
Medchemexpress LLC (D-Trp6)-LHRH free acid | 129418-54-8 | 99.7% | 1312.43 | 10 MG
(D-Trp6)-LHRH free acid is a luteinizing hormone-releasing hormone (LHRH) agonist. In vitro, (D-Trp6)-LHRH free acid (10 μM; 24 h or 6 days) reduces the proliferation of human epithelial ovarian cancer cell lines EFO-21 and EFO-27.
- Acts as a luteinizing hormone-releasing hormone (LHRH) agonist
- Reduces proliferation of human epithelial ovarian cancer cell lines EFO-21 and EFO-27
- High purity of 99.67%
- White to off-white solid appearance
Medchemexpress LLC PROTAC BET Degrader-10 | 1957234-97-7 | 99.4% | 783.29 | 1 ML
PROTAC BET Degrader-10 (dBET37) is a potent BET protein BRD4 degrader, connected by ligands for Cereblon and BRD4, with a DC50 of 49 nM. This compound utilizes PROTAC technology, containing two different ligands connected by a linker; one for an E3 ubiquitin ligase and the other for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Potent BET protein BRD4 degrader
- Connected by ligands for Cereblon and BRD4
- DC50 of 49 nM
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins
- For research use only
- Components include a BRD4(BD1BD2) ligand, a Cereblon ligand, and a linker
- Appearance is a solid
- Color is off-white to light yellow
Medchemexpress LLC 4-Methylumbelliferyl-α-d-mannoside | 28541-83-5 | 99.3% | 338.31 | 5 MG
4-Methylumbelliferyl-α-d-mannoside is a fluorescent substrate for α-D-mannosidase. For research use only.
- Fluorescent substrate for α-D-mannosidase.
- For research use only.
Medchemexpress LLC Integrin alpha X bet 50ug
Integrin -X/ -2 is a receptor for fibrinogen that recognizes GPR sequences It plays a key role in inflammatory responses particularly in monocyte adhesion and chemotaxis Integrin alpha X beta 2 Protein Human (HEK293 Flag His) is a recombinant protein dimer complex containing human-derived Integrin alpha X beta 2 protein expressed by HEK293 with C-His C-Flag labeled tag
Medchemexpress LLC D-(+)-cellobiose | 528-50-7 | MFCD00136034 | 99.8% | 342.30 | C12H22O11 | 10 MG
D-(+)-Cellobiose (Standard) is a high-purity analytical reference standard of the disaccharide D-(+)-cellobiose intended for research and analytical applications. It is supplied as a small packaged standard suitable for method development, calibration, and metabolite identification.
- High purity (99.84%).
- CAS number 528-50-7.
- Molecular weight 342.30 g/mol.
- White, water-soluble powder suitable for analytical use.
- Intended for method development, calibration, and metabolite identification.
Medchemexpress LLC BET bromodomain inhibitor | 1505453-59-7 | MFCD28144506 | 99.5% | 445.90 | C24H20ClN5O2 | 25 MG
BET bromodomain inhibitor is a research-grade small-molecule inhibitor of BET family bromodomain proteins used in preclinical and in vitro studies to probe transcriptional regulation, cell proliferation, and apoptosis. The compound has molecular formula C24H20ClN5O2 and a molecular weight of 445.90, and is supplied as a high-purity solid for laboratory use.
- Research use only; not for human or clinical use.
- Potent BET family bromodomain inhibition for mechanistic and cellular assays.
- High purity suitable for analytical and biological studies.
- Available in small solid quantities for laboratory experiments.
Medchemexpress LLC Integrin alpha 6 bet 5ug
Integrin alpha 6 beta 1 Protein Human (HEK293 Flag-His) is the recombinant human-derived Integrin alpha 6 beta 1 protein expressed by HEK293 with C-His C-Flag labeled tag has molecular weight of 110 130 kDa respectively
Medchemexpress LLC Guanylyl Cyclase beta 1 Antibody (YA2147) | 50 UL
The Guanylyl Cyclase beta 1 Antibody (YA2147) is a rabbit-derived, non-conjugated IgG monoclonal antibody specifically designed to target Guanylyl Cyclase beta 1. This antibody mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP, making it suitable for various research applications.
- Rabbit-derived recombinant monoclonal antibody
- Non-conjugated IgG isotype
- Targets Guanylyl Cyclase beta 1
- Reacts with human, mouse, and rat species
- Suitable for Western Blot (1:500-1:1000) and Immunohistochemistry-Paraffin (1:50-1:100) applications
- Stored at -20°C for one year
- Avoid repeated freeze/thaw cycles
- Formulated with 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide, and 0.05% BSA
Medchemexpress LLC KVA-D-88 | 2410550-31-9 | 99.81% | 382.19 | 25 MG
KVA-D-88 is a blood-brain barrier-permeable PDE4 inhibitor with IC50 values of 140 nM for PDE4B and 880 nM for PDE4D. It inhibits cocaine-induced hyperlocomotor activity and sensitization by selectively inhibiting PDE4B and reducing cAMP degradation, thereby modulating neuroadaptive responses. This compound can be utilized in the study of cocaine addiction.
- Blood-brain barrier-permeable PDE4 inhibitor
- Selectively inhibits PDE4B and reduces cAMP degradation
- Modulates neuroadaptive responses
- Inhibits cocaine-induced hyperlocomotor activity and sensitization
- Useful in the study of cocaine addiction