Fatty alcohol esters
Medchemexpress LLC Abiraterone acetate | 154229-18-2 | 99.9% | C26H33NO2 | 100 MG
Abiraterone acetate is an oral, potent, selective, and irreversible inhibitor of CYP17A1 with antiandrogen activity. It is an ester prodrug of Abiraterone, an anticancer agent that inhibits key enzymes involved in steroidogenesis.
- Potent, selective, and irreversible inhibitor of CYP17A1.
- Exhibits antiandrogen activity.
- Functions as an ester prodrug of Abiraterone.
- Inhibits 17,20-lyase and 17α-hydroxylase.
- Suppresses proliferation of AR-positive prostate cancer cell lines.
- Blocks synthesis of 5α-dione and DHT.
- Inhibits CRPC progression and prolongs survival in castration-resistant prostate cancer.
Medchemexpress LLC PNC-27 acetate | 99.98% | 4031.73 (free base) | 10 MG
PNC-27 acetate is a chimeric p53-penetratin peptide that binds to HDM-2 in a p53 peptide-like structure, inducing selective membrane-pore formation and leading to cancer cell lysis. It is an anticancer peptide that can be used in acute myeloid leukemia research.
- Binds to HDM-2 in a p53 peptide-like structure.
- Induces selective membrane-pore formation.
- Leads to cancer cell lysis.
- Anticancer peptide.
- Can be used in acute myeloid leukemia research.
- Induces cancer cell death (e.g., 100% cell death in MIA-PaCa-2 cells in 90 minutes at 50 μg/mL).
- Shows anti-leukemia activity in mice (e.g., reduced AML engraftment and prolonged survival at 40 mg/kg intraperitoneal injection once daily for 2-3 weeks).
Medchemexpress LLC Geranyl acetate | 105-87-3 | 1 ML
Geranyl acetate is an acyclic monoterpene ester derived from geraniol. Widely used in the cosmetics industry for its pleasant scent, it also acts as an apoptosis activator, showing significant anti-cancer activity against colo-205 cancer cells.
- Induces cell apoptosis
- Exhibits significant anti-cancer activity against colo-205 cancer cells
- Apoptosis associated with upregulation of Bax and downregulation of Bcl-2 expressions
- Acyclic monoterpene ester derived from geraniol
- Widely used in the cosmetics industry for its pleasant scent
- High purity of 99.74%
- Appearance: colorless to light yellow liquid
Medchemexpress LLC MK2-IN-5 acetate (Hsp25 kinase inhibitor acetate) | 99.64% | 1396.68 | 10 MG
MK2-IN-5 acetate (Hsp25 kinase inhibitor acetate) is a Mk2 pseudosubstrate with a Ki of 8 μM. It targets the protein interaction domain in the MAPK pathway and inhibits HSP25 and HSP27 phosphorylation. In vitro, MK2-IN-5 acetate (5-10 μM, 2 hours) inhibits TGF-β1 induced connective tissue growth factor (CTGF) and collagen type I in primary human keloid fibroblasts. In vivo, a single intraperitoneal injection of 2 mg/kg of MK2-IN-5 acetate decreased HSP25 phosphorylation in a ventilator-associated lung injury model.
Medchemexpress LLC L57 acetate | 99.0% | 2483.87 (free base) | 10 MG
L57 acetate is a Low-density lipoprotein receptor-related protein 1 (LRP1)-binding peptide. It demonstrates a high affinity for LRP1 with a Ki of 45 nM. This peptide also exhibits blood-brain barrier (BBB) permeability and plasma stability, making it a potential carrier for central nervous system (CNS) drug delivery.
- High affinity to LRP1 (Ki of 45 nM)
- Exhibits blood-brain barrier (BBB) permeability
- Demonstrates plasma stability
- Potential as a carrier for CNS drug delivery
Medchemexpress LLC TAT-QFNP12 acetate | 3006.47 (free base) | 1 MG
TAT-QFNP12 acetate is a peptide that plays a crucial role in cellular signaling pathways. It functions by blocking the NDRG2-PPM1A binding, which in turn reduces Smad2/3 phosphorylation. This peptide is also known to decrease astrocytic MMP-9 production and mitigate blood-brain barrier (BBB) disruption following subarachnoid hemorrhage (SAH).
- Blocks NDRG2-PPM1A binding
- Reduces Smad2/3 phosphorylation
- Decreases astrocytic MMP-9 production
- Mitigates blood-brain barrier (BBB) disruption after subarachnoid hemorrhage (SAH)
Medchemexpress LLC Indolicidin (acetate) | 99.6% | 1966.34 | 10 MG
Indolicidin acetate is a potent antimicrobial peptide purified from the cytoplasmic granules of bovine neutrophils. This product is for research use only.
- Potent antimicrobial peptide
- Purified from bovine neutrophils
- Molecular formula: C102H136N26O15
- Appearance: White to off-white solid
- Purity: 99.6%
- Molecular weight: 1966.34
Medchemexpress LLC A11 (acetate) | 98.5% | 2767.16 (free base) | 10 MG
A11 acetate is an ANXA1-derived 11 amino acid-long peptide that functions as an ANXA1-EphA2 interaction blocker peptide. It has a molecular weight of 2767.16 (free base) and a purity of 98.5%. This peptide is suitable for laboratory research applications.
- Functions as an ANXA1-EphA2 interaction blocker peptide
- 11 amino acid-long peptide
- High purity (98.5%)
- Recommended storage conditions for powder and in solvent