Glycerolipids
Medchemexpress LLC (Rac)-1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol sodium | 124011-52-5 | 100.0% | 100 MG
(Rac)-1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol (sodium) is an anionic phospholipid that can be used for drug delivery and liposome synthesis. It can induce Tregs specific for liposomes' cargo and is taken up by antigen-presenting cells mediated via complement component 1q (C1q).
- Anionic phospholipid
- Used for drug delivery and liposome synthesis
- Liposomes containing this compound can induce antigen-specific Tregs
- Taken up by antigen-presenting cells mediated via complement component 1q (C1q)
- Can reduce plaque formation and increase plaque stability in atherosclerotic mice
Sigma Aldrich Fine Chemicals Biosciences Glyceryl tributyrate >=99% | 60-01-5 | MFCD00009392 | 25ML
Glyceryl tributyrate >=99% | Purity: >=99% | Mol Wt: 302.36 | 60-01-5 | MFCD00009392 | 25ML
Medchemexpress LLC Triolein (standard) | 122-32-7 | 885.43 | 25 MG
Triolein (Standard) is the analytical standard of Triolein intended for research and analytical applications. It is a symmetric triacylglycerol that reduces upregulation of MMP-1 and has strong antioxidant and anti-inflammatory activities. This compound is commonly used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS, serving as a reference standard supplied for assay.
- Analytical standard for research
- Symmetric triacylglycerol
- Reduces upregulation of MMP-1
- Strong antioxidant and anti-inflammatory activities
- Suitable for HPLC research experiments
- Suitable for GC research experiments
- Suitable for MS research experiments
Selleck Chemical LLC uridine triacetate
Uridine triacetate (Vistonuridine PN401) is an orally active prodrug of the naturally occurring nucleoside uridine It is used for the treatment of hereditary orotic aciduria (Xuriden) or for the emergency treatment of fluorouracil or capecitabine overdose or toxicity
Cambridge Isotope Laboratories Trioctanoin (1 1 1-13C3 99%) 0 5 g
Trioctanoin (1 1 1-13C3 99%) 0 5 g
Medchemexpress LLC 9-Octadecenoic acid (9Z)-, 1,1',1''-(1,2,3-propanetriyl) ester | 122-32-7 | 885.43 | 500 MG
Triolein is a symmetric triacylglycerol that reduces the upregulation of MMP-1 and exhibits strong antioxidant and anti-inflammatory activities. It is intended for research use only.
- Reduces upregulation of MMP-1.
- Possesses strong antioxidant activity.
- Has anti-inflammatory activities.
Medchemexpress LLC Glyceryl triacetate | 102-76-1 | 99.9% | 10 G
Triacetin, also known as Glyceryl triacetate, is an orally active synthetic compound and triester of glycerol and acetic acid. It is notable for its ability to increase acetate bioavailability in glioma cells, leading to growth arrest and apoptosis. This compound can freely cross the blood-brain barrier and plasma membrane, increasing histone acetylation and enhancing the chemotherapeutic efficacy of Temozolomide.
- Increases acetate bioavailability in glioma cells
- Induces glioma cell growth arrest and apoptosis
- Freely crosses blood-brain barrier and plasma membrane
- Increases histone acetylation
- Enhances chemotherapeutic efficacy
- Inhibits HDAC-8 activity
- Activates mTOR complexes downstream genes
- Shows increased tumor suppressor miRs
Medchemexpress LLC Ag 538 | 133550-18-2 | MFCD00080276 | 99.8% | 297.26 | C16H11NO5 | 5 MG
AG 538 is a small-molecule, competitive inhibitor of the insulin-like growth factor-1 receptor (IGF-1R) kinase with a reported IC50 of approximately 400 nM. It is supplied as a high-purity research reagent intended for biochemical and cell-based studies.
- Potent, competitive IGF-1R kinase inhibitor with IC50 ≈ 400 nM.
- High purity suitable for research applications (99.8%).
- Applicable to biochemical kinase assays and cell-based signaling studies.
- Supplied in small, precise sample sizes for laboratory testing.
- Molecular formula C16H11NO5; molecular weight 297.26.
Medchemexpress LLC MI-538 | 1857417-10-7 | 98.0% | 566.60 | 25 MG
MI-538 is an inhibitor of the interaction between menin and MLL fusion proteins with an IC50 of 21 nM. For research use only. We do not sell to patients.
- Inhibits the proliferation of MLL leukemia cells with a GI50 of 83 nM.
- Shows selectivity toward MLL fusion protein transformed cells, with no effect (up to 6 μM) on control cell lines HL-60 and HM-2 that do not harbor MLL translocations.
- Binds to menin with low nanomolar affinity (Kd=6.5 nM).
- Potent cellular activity due to improved binding affinity to menin and possibly increased cell membrane permeability.
- Results in strong down-regulation of Hoxa9 and Meis1 gene expression.
- In vivo, it causes an approximately 80% reduction in MV4;11 tumor volume without significant toxicity.
- Demonstrates improved exposure (AUC values), Cmax, and lowest clearance in blood plasma.
- Has a half-life of about 1.6 h and high oral bioavailability (~50%).
Medchemexpress LLC 1H-Indole-2-carbonitrile, 6-hydroxy-1-(1H-pyrazol-4-ylmethyl)-5-[[4-[[6-(2,2,2-trifluor... | 1857417-10-7 | 98.2% | 566.60 | 1 MG
MI-538 is an inhibitor of the interaction between menin and MLL fusion proteins with an IC50 of 21 nM. It is for research use only and not sold to patients.
- Inhibits the proliferation of MLL leukemia cells with a GI50 of 83 nM.
- Shows selectivity towards MLL fusion protein transformed cells.
- Binds to menin with a Kd of 6.5 nM.
- Leads to strong down-regulation of Hoxa9 and Meis1 gene expression.
- Reduces tumor volume in mice xenografts.
- Improved exposure and Cmax in blood plasma.
- Low clearance and a half-life of about 1.6 hours.
- High oral bioavailability (~50%).
- Soluble in DMSO.
- Soluble in various in vivo protocols, including 10% DMSO, 40% PEG300, 5% Tween-80, 45% Saline.
Medchemexpress LLC 1,3-glyceryl dilinoleate | 15818-46-9 | MFCD00056310 | ≥95.0% | 616.95 g·mol⁻¹ | C39H68O5 | 25 MG
1,3-Glyceryl dilinoleate is an unsaturated diacylglycerol used as a research reagent in lipid chemistry and biochemical studies. It has chemical formula C39H68O5 and a molecular weight of 616.95 g·mol⁻¹, and is commonly supplied in small-mass packages for laboratory use.
- Used as a reagent in lipid and membrane research.
- Chemical formula C39H68O5 and molecular weight 616.95 g·mol⁻¹.
- CAS number 15818-46-9 for unambiguous identification.
- Commonly supplied in mg-scale quantities for analytical and research use.
- Typically provided at high purity suitable for research applications.