Sphingolipids
Cayman Chemical C8 CeramIde-1-phosphated1810mg
C8 ceramide-1-phosphate is a short-chain analog of the naturally occurring ceramide-1-phosphate. The effects of C8 ceramide-1-phosphate are essentially the opposite of C8 ceramide; it induces DNA synthesis and cell division. The effects of C8 ceramide-1-phosphate can be attenuated by simultaneous treatment with C2 or C8 ceramide.{5183}
Cayman Chemical C8 CeramIde-1-phosphated1825mg
C8 ceramide-1-phosphate is a short-chain analog of the naturally occurring ceramide-1-phosphate. The effects of C8 ceramide-1-phosphate are essentially the opposite of C8 ceramide; it induces DNA synthesis and cell division. The effects of C8 ceramide-1-phosphate can be attenuated by simultaneous treatment with C2 or C8 ceramide.{5183}
Medchemexpress LLC 17:1 Lyso PC | 1246304-62-0 | C25H50NO7P | 50 MG
17:1 Lyso PC is a liposome designed to simulate biological phospholipid membranes. These liposomes, composed of concentric phospholipid bilayer membranes, can be utilized to create drug delivery systems for both anti-cancer and anti-infection applications. They are capable of trapping highly polar water-soluble payloads within their internal aqueous space, while lipophilic payloads can integrate into the lipid bilayer. This product is particularly effective for delivering antisense oligonucleotides, addressing issues such as inefficient cellular uptake and rapid loss within the body.
- Simulates biological phospholipid membranes
- Utilized for anti-cancer and anti-infection drug delivery systems
- Traps highly polar water-soluble payloads within internal aqueous space
- Integrates lipophilic payloads into the lipid bilayer
- Effective for delivering antisense oligonucleotides
Medchemexpress LLC C22-Ceramide | 27888-44-4 | C40H79NO3 | 50 MG
C22-Ceramide (Cer d18:1/22:0) is an endogenous bioactive sphingolipid. It functions by reducing the propensity of C16-ceramide channel formation in isolated rat liver mitochondria and in liposomes. It has a molecular weight of 622.06 and appears as a white to off-white solid with a purity of 99.89%.
- Endogenous bioactive sphingolipid
- Reduces propensity of C16-ceramide channel formation
- High purity (99.89%)
- Available in various quantities for research use
Medchemexpress LLC DMTr-2'-O-C22-rA-3'-CE-Phosphoramidite | 2923115-67-5 | 98.0% | 1182.52 | 10 MM * 1 ML
DMTr-2'-O-C22-rA-3'-CE-Phosphoramidite (Compound 103) is a phosphoramidite that can be used for the synthesis of oligonucleotide. It targets DNA/RNA Synthesis and is involved in the Cell Cycle/DNA Damage pathway.
- Phosphoramidite compound for oligonucleotide synthesis
- Synthesis of oligonucleotide
Medchemexpress LLC Sphingomyelin | 85187-10-6 | ≥99.0% | 10 MG
Sphingomyelin is a eukaryotic sphingolipid and a primary component of cell membranes, especially abundant in the myelin sheath surrounding neuronal axons. It is significant in cell processes, regulating inflammatory responses, and signal transduction. Its metabolism is linked to various central nervous system diseases and Niemann-Pick disease.
- Eukaryotic sphingolipid
- Major constituent of cell membranes
- Abundant in myelin sheath
- Involved in cell processes
- Regulates inflammatory responses
- Involved in signal transduction
- Metabolism linked to central nervous system diseases and Niemann-Pick disease
- Metabolism produces interconvertible bioactive sphingolipids
- Enriches lipid raft-mediated cell signaling
Medchemexpress LLC C2 ceramide | 3102-57-6 | MFCD00153903 | 99.9% | 341.53 | C20H39NO3 | 50 MG
C2 Ceramide is a short-chain ceramide used as a research reagent to study ceramide signaling, protein phosphatase activation, apoptosis, autophagy, and skin barrier function. Supplied as a solid at high purity, it is intended for laboratory biochemical and cell-based assays under recommended storage conditions.
- Activates protein phosphatases and modulates ceramide signaling.
- Induces apoptosis and autophagy in cellular models.
- Acts as a skin conditioning agent protecting epidermal barrier function.
- Available in multiple pack sizes, including 50 MG, for laboratory use.
- High purity suitable for research applications; follow recommended storage and handling.
Medchemexpress LLC 17:1 Lyso PC | 1246304-62-0 | C25H50NO7P | 100 MG
17:1 Lyso PC is a liposome designed to simulate biological phospholipid membranes, utilized in constructing drug delivery systems for anti-cancer and anti-infection applications.
- Encapsulates highly polar water-soluble payloads
- Lipophilic payloads can integrate into the lipid bilayer
- Effective for delivering antisense oligonucleotides
- Addresses inefficient cellular uptake
- Addresses rapid degradation in the body
Enzo Life Sciences 3-O-Methyl-Sphingomyelin (5 mg)
3-O-Methyl-Sphingomyelin is a novel selective inhibitor of neutral sphingomyelinase, (Ki=37 µM). It is cell-permeable and does not inhibit acid sphingomyelinase. Purity: ≥98% (TLC). Solubility: Soluble in ethanol (>25 mg/ml) or DMSO (20 mg/ml@50°C). Long Term Storage: -20°C.
Medchemexpress LLC C16 ceramide (N-palmitoylsphingosine, D-erythro) | 24696-26-2 | MFCD00056205 | 98.0% | 537.90 | C34H67NO3 | 25 MG
C16 ceramide is a naturally occurring sphingolipid (N-palmitoylsphingosine) used as a research reagent that activates p53 through direct, selective binding. Supplied as a white to off-white solid, it is used in cell biology studies of apoptosis, cell signaling, and mitochondrial membrane permeability. Store protected from light at 4°C; in solution store at -80°C (long term) or -20°C (short term).
- Activates p53 through direct, selective binding.
- Endogenous sphingolipid for studies of apoptosis and cell signaling.
- Supplied as a stable solid, white to off-white in color.
- Compatible with common organic solvents; prepare fresh solutions and protect from light.
- Intended for research use only.
Medchemexpress LLC C8 PEG750 ceramide | 212116-76-2 | 99.9% | 750.0 g/mol (average) | (C2H4O)nC31H57NO6 | 5 MG
C8 PEG750 ceramide is a PEGylated ceramide lipid used to form lipid bilayer carriers such as liposomes and lipid nanoparticles for selective delivery of diagnostic and therapeutic agents to acidic diseased cells. It is provided as a high-purity research reagent suitable for formulation development and analytical studies.
- High purity for reliable formulation and analysis.
- PEGylated ceramide structure for steric stabilization of lipid assemblies.
- Average molecular weight ~750 supports PEG shielding properties.
- Suitable for liposome and LNP formulation development.
- Available in small milligram pack sizes for research use.
Cayman Chemical Sphinganine d18 0
A precursor of ceramide and sphingosine; can emulate S1P in cell signaling or have opposite intracellular effects