Sphingolipids
Cayman Chemical C16 Sphingomyelin d18 1 16 0
A naturally occurring sphingolipid; levels are elevated in the prefrontal cortex and cerebellum in a rat model of STZ-induced diabetes, as well as in the liver in mouse models of Niemann-Pick type C1 disease; plasma are decreased in patients with prostate cancer; has been used in model membranes with POPC and cholesterol in the study of lipid raft dynamics and membrane organization
Medchemexpress LLC N-Myristoyl-D-sphingosine | 34227-72-0 | MFCD01320386 | 99.9% | 509.85 g/mol | C32H63NO3 | 10MG
C14 ceramide (N-myristoyl-D-sphingosine) is a research-grade sphingolipid provided in ester form for laboratory use. It is intended for in vitro biochemical and cell biology studies of sphingolipid metabolism and signaling. The material is for research use only and is not for human or clinical applications.
Cayman Chemical C8 CeramIde-1-phosphated181mg
C8 ceramide-1-phosphate is a short-chain analog of the naturally occurring ceramide-1-phosphate. The effects of C8 ceramide-1-phosphate are essentially the opposite of C8 ceramide; it induces DNA synthesis and cell division. The effects of C8 ceramide-1-phosphate can be attenuated by simultaneous treatment with C2 or C8 ceramide.{5183}
Cayman Chemical C6 NBD dihydro Ceramide d18
Structurally identical to C6 NBD ceramide, but contains a saturated bond in the C-4/C-5 position of the sphingosine backbone
Cayman Chemical C20 Ceramide d18 1 20 0
A natural 20:0 ceramide that is abundant in the brain; synthesized de novo by ceramide synthases 1 and 2
Medchemexpress LLC DHA ceramide | 218608-43-6 | 98.7% | 609.96 | C40H67NO3 | 10 MG
DHA Ceramide (C22:6 Ceramide) is a high-purity ester-form ceramide supplied as a solid for biochemical and cell biology research. It is intended for in vitro use and is typically prepared in DMSO for cellular treatments. Store the dry material at -20°C protected from light and under nitrogen; reconstituted solutions have recommended cold storage lifetimes.
- High purity (98.65%) suitable for research applications.
- Available in small milligram-scale packages for flexible experimental use.
- Solid form soluble in DMSO at 100 mg/mL; ultrasonic treatment recommended.
- Provides molecular formula C40H67NO3 and molecular weight 609.96 g/mol for experimental planning.
- Recommended storage: store at -20°C protected from light and under nitrogen; solutions: -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC N-heptadecanoyl-d-erythro-sphingosylphosphorylcholine | 121999-64-2 | 99.7% | 717.05 g/mol | C40H81N2O6P | 5 MG
C17 sphingomyelin (d18:1/17:0) is a synthetic sphingomyelin analog used as an internal standard for quantitative lipid analysis, particularly mass spectrometry-based sphingomyelin quantification. It is provided as a high-purity analytical-grade solid suitable for LC-MS workflows.
- High purity (99.67%) for reliable quantitation.
- Molecular formula C40H81N2O6P; molecular weight 717.05 g/mol.
- Suitable as an internal standard for LC-MS quantitation of sphingomyelin.
- Available in small pack sizes for analytical use.
Sigma Aldrich Fine Chemicals Biosciences Sphingomyelin Quantificati
Sphingomyelin a sphingolipid consisting of a phospholipid (typically phosphocholine) attached to a ceramide moiety is a major component of cellular membranes. Sphingomyelin is enriched in the exoplasmic leaflet of the cell membrane. Within the cell membrane sphingomyelin interacts with cholesterol to form lipid rafts. The metabolism of sphingomyelin contributes to cellular signaling via the release of ceramide a second messenger that participates in multiple cellular signaling pathways. Sphingomyelin accumulates in Niemann-Pick disease due to deficiencies in sphingomyelinase activity. Increased levels of sphingomyelin is observed in hypercholesterolemia which is characterized by the accumulation of sphingomyelin in arteriosclerotic lesions resulting in ischemic heart disease.
