Sphingolipids
Sigma Aldrich Fine Chemicals Biosciences Colorimetric Sphingomyelin
Sphingomyelinase (SMase) or sphingomyelin phosphodiesterase catalyzes the hydrolytic cleavage of sphingolipid to phosphocholine and ceramide a second messenger involved in multiple cellular responses including the cellular response to stress. There are at least 5 types of SMases identified which are classified according to their cation dependence cellular location and pH optima for activity and include the acidic and neutral sphingomyelinase. Neutral SMases along with the acidic SMases are thought to be major contributors to the production of ceramide in response to cellular stress.
Enzo Life Sciences 3-O-Methyl-Sphingomyelin (1 mg)
3-O-Methyl-Sphingomyelin is a novel selective inhibitor of neutral sphingomyelinase, (Ki=37 µM). It is cell-permeable and does not inhibit acid sphingomyelinase. Purity: ≥98% (TLC). Solubility: Soluble in ethanol (>25 mg/ml) or DMSO (20 mg/ml@50°C). Long Term Storage: -20°C.
Enzo Life Sciences 3-O-Methyl-Sphingomyelin (5 mg)
3-O-Methyl-Sphingomyelin is a novel selective inhibitor of neutral sphingomyelinase, (Ki=37 µM). It is cell-permeable and does not inhibit acid sphingomyelinase. Purity: ≥98% (TLC). Solubility: Soluble in ethanol (>25 mg/ml) or DMSO (20 mg/ml@50°C). Long Term Storage: -20°C.
Medchemexpress LLC 17:1 lyso pc | 1246304-62-0 | 98.0% | 507.64 | C25H50NO7P | 10 MG
17:1 Lyso PC is a lysophosphatidylcholine lipid used to simulate biological phospholipid membranes and to formulate liposomes for drug delivery research. It forms vesicles with concentric phospholipid bilayers, enabling encapsulation of polar, water-soluble payloads in the internal aqueous space and incorporation of lipophilic payloads within the lipid layer. It is commonly used in studies of anticancer, anti-infection, and nucleic-acid delivery.
- Molecular formula: C25H50NO7P.
- Molecular weight: 507.64.
- Purity: 98.0%.
- CAS number: 1246304-62-0.
- Appearance: white to off-white solid-liquid mixture.
- Storage: -20°C (pure form, long term); -80°C (in solvent, short term).
- Pack size: 10 mg.
- Typical applications: liposome formulation and nucleic-acid delivery research.
TARGETMOL CHEMICALS INC C22 Ceramide d18 1 22 0 10MG
Also available in 1 mg, 5 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. C22 Ceramide (d181/220) (C22 Ceramide), a long-chain ceramide containing behenic acid, is an endogenous bioactive sphingolipid.C22-Ceramide specifically inhibits MCSR and reduces C16 ceramide channel formation in isolated rat liver mitochondria and liposomes. Purity 97.97%
Apexbio Technology LLC Lyso-Tracker Red(Synonyms: LysoTracker Red DND-99, LysoTracker Red, LysoTracker Red fluorescent probe), 50ul, CAS: 231946-72-8.
Lyso-Tracker Red (CAS 231946-72-8) is a weakly basic fluorescent dye designed for labeling lysosomes in live cells. This cell-permeable molecule selectively accumulates within acidic lysosomal compartments due to protonation and subsequent entrapment in their low-pH environment. Unlike conventional lysosomal dyes such as neutral red and acridine orange, Lyso-Tracker Red displays superior organelle specificity, requiring nanomolar concentrations to clearly visualize lysosomes. Supplied as a 1 mM stock solution in DMSO, this probe is utilized for live-cell imaging studies investigating lysosomal function and trafficking pathways.
Apexbio Technology LLC Lyso-Tracker Green(Synonyms: LysoTracker Green DND-26, LysoTracker Green, LysoTracker Green lysosomal probe), 50ul.
Lyso-Tracker Green is a fluorescent small-molecule probe designed specifically for labeling lysosomes in living cells. As a weakly basic fluorophore, it accumulates selectively in acidic cellular compartments, primarily lysosomes, due to protonation under low pH conditions. Unlike conventional dyes such as acridine orange or neutral red, Lyso-Tracker Green exhibits superior organellar selectivity and requires only nanomolar concentrations to produce robust fluorescent labeling. It is widely utilized in biomedical research for imaging lysosomal localization and analyzing cellular physiology in live-cell assays, but is not compatible with fixed-cell staining protocols.
Medchemexpress LLC C8 PEG750 ceramide | 212116-76-2 | 99.9% | 750.0 g/mol (average) | (C2H4O)nC31H57NO6 | 5 MG
C8 PEG750 ceramide is a PEGylated ceramide lipid used to form lipid bilayer carriers such as liposomes and lipid nanoparticles for selective delivery of diagnostic and therapeutic agents to acidic diseased cells. It is provided as a high-purity research reagent suitable for formulation development and analytical studies.
- High purity for reliable formulation and analysis.
- PEGylated ceramide structure for steric stabilization of lipid assemblies.
- Average molecular weight ~750 supports PEG shielding properties.
- Suitable for liposome and LNP formulation development.
- Available in small milligram pack sizes for research use.
![Medchemexpress LLC [(2R)-2-hydroxy-3-tetracosanoyloxypropyl] 2-(trimethylazaniumyl)ethyl phosphate | 325171-59-3 | MFCD00674360 | 99.7% | 607.84 g/mol | C32H66NO7P | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000222171.png-250.jpg)
Medchemexpress LLC [(2R)-2-hydroxy-3-tetracosanoyloxypropyl] 2-(trimethylazaniumyl)ethyl phosphate | 325171-59-3 | MFCD00674360 | 99.7% | 607.84 g/mol | C32H66NO7P | 5 MG
24:0 Lyso PC is a lysophospholipid supplied as a purified white to off-white solid for research use. It is used in studies of lipid metabolism and to formulate lipid nanoparticles for nucleic acid (mRNA) delivery, and is provided with documented chemical identity and stability data.
- Lysophospholipid useful for lipid nanoparticle formulation and mRNA delivery studies.
- High purity suitable for analytical and formulation research.
- White to off-white solid form, convenient for handling and storage.
- Stable under recommended storage conditions (powder at -20°C up to 3 years).
- Defined chemical identity and molecular weight for reproducible results.
Cayman Chemical C12 NBD Ceramide d18 1 12 0
C12 NBD ceramide (d18:1/12:0) is a long-chain fluorescent ceramide analog that can be used for the measurement of alkaline and neutral ceramidase activity.{14063} It is hydrolyzed efficiently by alkaline ceramidase from P. aeruginosa and by neutral ceramidase from mouse liver. In addition, alkaline and neutral ceramidases from a variety of mammalian cell lines also hydrolyze C12 NBD ceramide (d18:1/12:0). Acid ceramidase does not appear to utilize C12 NBD ceramide (d18:1/12:0) as a substrate. The possibility exists forC12 NBD ceramide (d18:1/12:0) to also be applied to the measurement of ceramide kinase and/or sphingomyelin synthase activity.
Cayman Chemical C12 NBD Ceramide d18 1 12 0
C12 NBD ceramide (d18:1/12:0) is a long-chain fluorescent ceramide analog that can be used for the measurement of alkaline and neutral ceramidase activity.{14063} It is hydrolyzed efficiently by alkaline ceramidase from P. aeruginosa and by neutral ceramidase from mouse liver. In addition, alkaline and neutral ceramidases from a variety of mammalian cell lines also hydrolyze C12 NBD ceramide (d18:1/12:0). Acid ceramidase does not appear to utilize C12 NBD ceramide (d18:1/12:0) as a substrate. The possibility exists forC12 NBD ceramide (d18:1/12:0) to also be applied to the measurement of ceramide kinase and/or sphingomyelin synthase activity.
Cayman Chemical C12 NBD Ceramide d18 1 12 0
C12 NBD ceramide (d18:1/12:0) is a long-chain fluorescent ceramide analog that can be used for the measurement of alkaline and neutral ceramidase activity.{14063} It is hydrolyzed efficiently by alkaline ceramidase from P. aeruginosa and by neutral ceramidase from mouse liver. In addition, alkaline and neutral ceramidases from a variety of mammalian cell lines also hydrolyze C12 NBD ceramide (d18:1/12:0). Acid ceramidase does not appear to utilize C12 NBD ceramide (d18:1/12:0) as a substrate. The possibility exists forC12 NBD ceramide (d18:1/12:0) to also be applied to the measurement of ceramide kinase and/or sphingomyelin synthase activity.
Medchemexpress LLC C26-ceramide | 121459-09-4 | MFCD18379264 | 99.9% | 678.17 g/mol | C44H87NO3 | 1 MG
C26-Ceramide is a very long-chain ceramide lipid consisting of a sphingoid base N-acylated with a C26 fatty acid. It is supplied as a high-purity biochemical reagent for lipid research and formulation work, including development of lipid nanoparticles and liposomes.
- Very long-chain ceramide with one saturated and one unsaturated hydrophobic tail.
- High purity (approximately 99.9%) suitable for analytical and formulation studies.
- Molecular weight 678.17 g/mol; chemical formula C44H87NO3.
- Supplied in small research quantities (example: 1 mg) for experimental use.
- Stable as a powder when stored at -20 °C; follow laboratory handling and storage guidelines.