Steroids and derivatives
Medchemexpress LLC Ciraparantag acetate | 1644388-83-9 | 98.0% | 873.01 | 5 MG
Ciraparantag acetate (PER977) is a thrombin and factor Xa inhibitor that functions as a broad-spectrum reversal agent for anticoagulants, including low molecular weight heparins, unfractionated heparins, and some direct oral anticoagulants. It does not reverse Vitamin K antagonists (VKAs).
- Small, synthetic, and cationic molecule
- Binds to direct Factor Xa inhibitors and direct thrombin inhibitors
- Binds to unfractionated and low molecular weight heparin (LMWH) through non-covalent hydrogen bonds and charge-charge interactions
- Shows reversal of anticoagulants in rat-tail transection bleeding assays
- Reduces bleeding as observed in thromboelastography studies
- Soluble in H2O at 125 mg/mL (requires ultrasonic treatment)
Medchemexpress LLC Norethisterone enanthate | 3836-23-5 | 99.19% | C27H38O3 | 250 MG
Norethisterone enanthate is a long-acting parenteral progestogen, orally active, and functions as a click chemistry reagent. It contains an alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups. This compound is intended for research use only.
- Long-acting parenteral progestogen
- Orally active
- Functions as a click chemistry reagent
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Can be used as an intramuscular contraceptive agent in vitro
- Inhibits fertility in female rats in vivo
- White to off-white solid appearance
- Soluble in DMSO (200 mg/mL)
Medchemexpress LLC Bazedoxifene (acetate) | 198481-33-3 | 99.9% | C32H38N2O5 | 25 MG
Bazedoxifene acetate is an oral, nonsteroidal selective estrogen receptor modulator (SERM) that acts as an inhibitor of IL-6/GP130 protein-protein interactions. It is used in research for osteoporosis and pancreatic cancer.
- Small molecular GP130 inhibitor
- Inhibits STAT3 phosphorylation induced by IL-6 and IL-11
- Induces apoptosis in human pancreatic cancer cells
- Inhibits STAT3 nuclear translocation induced by IL-6
- Blocks cell migration in pancreatic cancer cells by inhibiting GP130
- Inhibits Capan-1 tumor growth in mouse models
Medchemexpress LLC Velmupressin acetate | 1647120-04-4 | 99.5% | 1006.63 | 10 MG
Velmupressin acetate is a potent, selective, and short-acting peptidic V2 receptor (V2R) agonist. It exhibits high affinity for both human (hV2R) and rat (rV2R) V2 receptors, with EC50s of 0.07 nM and 0.02 nM respectively. This product is intended for research purposes only.
- Potent and selective V2 receptor agonist
- Short-acting peptidic compound
- High affinity for human and rat V2 receptors
- For research purposes only
Medchemexpress LLC Velmupressin acetate | 1647120-04-4 | 1006.64 g/mol | 1 MG
Velmupressin acetate is a potent, selective, and short-acting peptidic V2 receptor (V2R) agonist. It exhibits EC50 values of 0.07 nM for human V2R (hV2R) and 0.02 nM for rat V2R (rV2R). This product is stable under recommended storage conditions and is not classified as a hazardous substance or mixture according to safety data.
- Potent, selective, and short-acting peptidic V2 receptor (V2R) agonist
- EC50 values of 0.07 nM for human V2R (hV2R)
- EC50 values of 0.02 nM for rat V2R (rV2R)
- Stable under recommended storage conditions
- Not a hazardous substance or mixture
- For research use only
Apexbio Technology LLC Deoxycorticosterone acetate 56-47-3 10mM (in 1mL DMSO)
Deoxycorticosterone acetate (56-47-3) is a small-molecule agonist targeting mineralocorticoid receptors (MR) It is designed to activate MR thereby regulating renal sodium reabsorption and potassium excretion Deoxycorticosterone acetate exerts its biological activity primarily through interaction with cytoplasmic mineralocorticoid receptors leading to nuclear translocation and modulation of electrolyte balance Typical IC50 values associated with its mineralocorticoid receptor binding affinity have been reported in the nanomolar range Based on these pharmacological properties Deoxycorticosterone acetate holds research potential in studies of electrolyte balance adrenal insufficiency modeling and the pathophysiology of hypertension as well as models investigating mineralocorticoid receptor-dependent signaling and renal or cardiovascular physiology
TARGETMOL CHEMICALS INC MEDROXYPROGESTERONE 500MG
Also available in 50 mg 100 mg 1000 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Medroxyprogesterone is used in the treatment of renal carcinoma. It is a synthetic progestational hormone used in veterinary practice as an estrus regulator. purity: 99%
Medchemexpress LLC Oxyphenisatin acetate | 115-33-3 | MFCD00022793 | 98.0% | 401.41 | C24H19NO5 | 50 MG
Oxyphenisatin acetate is the acetylated prodrug of oxyphenisatin, historically used as a laxative. This listing describes a research-grade chemical supplied for analytical and laboratory studies; it is intended for research use only and not for human or veterinary use.
- Acetylated prodrug of oxyphenisatin.
- Used in biochemical and autophagy-related research.
- CAS number: 115-33-3.
- Molecular formula C24H19NO5 and molecular weight ~401.41.
- Typically supplied as a solid with high purity (commonly ≥98%).
Medchemexpress LLC Trans-Doxercalciferol | 74007-20-8 | 98.2% | C28H44O2 | 5 MG
trans-Doxercalciferol is a chemical intended for research use only, suitable for laboratory applications and the manufacture of substances. It is a solid that must be handled by qualified scientists in equipped facilities.
- For research use only
- High purity
- Suitable for laboratory applications
- Can be used in substance manufacturing
- Stable under recommended storage conditions
Apexbio Technology LLC PYRAZINAMIDE-D3-1MG
Pyrazinamide-d3 (CAS No 1432059-16-9) is a deuterium-labeled derivative used in biomedical research as a stable isotope for various studies Originating from antimicrobial research it is primarily utilized to investigate Mycobacterium tuberculosis the causative agent of tuberculosis Pyrazinamide-d3 acts by disrupting the bacterial membrane potential and interfering with fatty acid synthase I which is critical for the bacterium s survival and replication In vitro studies frequently demonstrate its activity in the nanomolar to low micromolar range making it effective for precise quantitative analysis This compound is commonly applied in cell models animal studies and drug screening assays to measure drug metabolism and pharmacokinetics Experimental concentrations typically depend on the specific research design allowing for flexibility across various experimental frameworks ultimately aiding in the development of novel therapeutics against bacterial infections
Medchemexpress LLC Skatole-d3 | 111399-60-1 | 134.19 | 1 MG
Skatole-d3 is the deuterium labeled Skatole. It is produced by intestinal bacteria and regulates intestinal epithelial cellular functions by activating aryl hydrocarbon receptors and p38. It is for research use only. Deuteration has gained attention due to its potential to affect the pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC 1-Methyladenine-d3 | 15763-06-1 | 284.29 | 10 MG
1-Methyladenosine-d3 is the deuterium-labeled version of 1-Methyladenosine. 1-Methyladenosine is an RNA modification that can act as a tumor marker, with elevated levels linked to cancer development. The methylation of 1-methyladenosine leads to the upregulation of PPARδ expression, which regulates cholesterol metabolism and activates the Hedgehog signaling pathway, thereby promoting liver tumorigenesis.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by methods such as NMR, GC-MS, or LC-MS.
- Deuteration is used in drug molecules primarily as tracers for quantitation during drug development.
- Has the potential to influence the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Platycodin D2 | 66663-90-9 | 10 MM * 1 ML
Platycodin D2 is a saponin isolated from Platycodon grandiflorum, known for its anti-cancer activity and intended for research use only.
- High purity: 99.78%
- Molecular weight: 1387.46
- Appearance: Off-white to light yellow solid
- Exhibits antiproliferative activity against human HCT-15 and MES-SA cells
- Available as a 10 mM solution in DMSO