Steroids and derivatives
Medchemexpress LLC Dopamine D2 receptor antagonist-1 | 1055411-77-2 | 99.1% | 25 MG
Dopamine D2 receptor antagonist-1 is a negative allosteric modulator (NAM) of the dopamine D2 receptor (D2R) with sub-millimolar affinity. It is intended for research use only, not for use in patients.
- Functions as a negative allosteric modulator of the dopamine D2 receptor (D2R)
- Exhibits sub-millimolar affinity
- Intended for research use only
Medchemexpress LLC Vitamin D3 | 67-97-0 | C27H44O | 5 G
Vitamin D3 (Cholecalciferol; Colecalciferol) is a naturally occurring form of vitamin D. It induces cell differentiation and prevents the proliferation of cancer cells, playing a crucial role in various biological activities for research use.
- Naturally occurring form of vitamin D.
- Induces cell differentiation and prevents proliferation of cancer cells.
- Undergoes two hydroxylation processes to become biologically active in vivo.
- Active form is 1,25-dihydroxycholecalciferol (calcitriol).
- Exhibits anti-proliferative effects in various cell lines in a dose- and time-dependent manner.
- Increases nuclear VDR staining and produces local VDR activation in IK cells.
- Potentiates CCl4 toxicity in the liver and increases renal calcium levels in mice in vivo.
Medchemexpress LLC 1α,25-dihydroxy-3-epi-vitamin D3 | 61476-45-7 | MFCD28963706 | 98.5% | 416.64 g·mol⁻1 | C27H44O3 | 5 MG
1S-Calcitriol is a stereoisomer of calcitriol (1α,25-dihydroxyvitamin D3) that functions as a potent vitamin D receptor (VDR) agonist. It is provided as a high-purity solid research reagent for use in cellular, biochemical, and pharmacological studies of VDR signaling, calcium homeostasis, and related physiological processes.
- Potent vitamin D receptor agonist.
- Useful for studying keratinocyte proliferation and differentiation.
- Supports investigation of parathyroid hormone regulation and calcium signaling.
- Provided as a high-purity solid for analytical and biological assays.
- Chemical formula C27H44O3; molecular weight 416.64 g·mol⁻1.
Medchemexpress LLC Elexacaftor-d3 (VX-445-d3) | 2216712-66-0 | 98.3% | 600.67 | 1 MG
Elexacaftor-d3 (VX-445-d3) is a deuterium labeled compound, serving as a tracer and internal standard for quantitative analysis methods such as NMR, GC-MS, or LC-MS. Deuteration may influence the pharmacokinetic and metabolic profiles of drugs. Its unlabeled counterpart, Elexacaftor (VX-445), acts as a next-generation cystic fibrosis transmembrane conductance regulator (CFTR) corrector, aiming to restore Phe508del CFTR protein function and treat cystic fibrosis.
- Deuterium labeled compound
- Used as a tracer
- Used as an internal standard for quantitative analysis
- Potential to affect pharmacokinetic and metabolic profiles of drugs
- Restores Phe508del CFTR protein function
- Has potential to treat cystic fibrosis
- Improves Phe508del CFTR protein processing, trafficking, and chloride transport
Cayman Chemical ArachIdIc AcId-d3 10mg
An internal standard for the quantification of arachidic acid by GC- or LC-MS
BIOHIPPO AAV-D2-BFP-WPRE-hGH-pA
Recombinant adeno associated virus expressing BFP under the D2 promoter with WPRE and hGH polyA elements. Offered under the Biohippo AAVX Series with multiple serotypes available including AAV2/1, AAV2/2, AAV2/5, AAV2/6, AAV2/6m, AAV2/6.2FF, AAV2/7m8, AAV2/8, AAV2/9, AAV2/DJ, AAV2/DJ8, AAV2/Retro, AAV2/PHP.eB, AAV2/PHP.B, AAV2/rh10, AAV2/PHP.S, AAV2/anc80, AAV2/B10, AAV2/olig001, AAV2/BI30, AAV2/BR1, AAV2/MG1.2, AAV1/2, AAV2/MaCPNS1, and AAV2/MaCPNS2. Regular titer is greater than or equal to 2.00E+12 vg per mL, with high titer greater than or equal to 1.00E+13 vg per mL available upon request at no additional cost. Customers may specify preferred serotype and titer when placing orders.
Cambridge Isotope Laboratories Melatonin (acetyl-D3 98%) CP 95% 10 mg
Melatonin (acetyl-D3 98%) CP 95% 10 mg
BIOHIPPO AAV-D2-hChR2(E123T/T159C)-mCherry-WPRE-hGH-polyA
Recombinant adeno associated virus expressing hChR2(E123T/T159C) fused to mCherry under the D2 promoter with WPRE and hGH polyA elements. Offered under the Biohippo AAVX Series with multiple serotypes available including AAV2/1, AAV2/2, AAV2/5, AAV2/6, AAV2/6m, AAV2/6.2FF, AAV2/7m8, AAV2/8, AAV2/9, AAV2/DJ, AAV2/DJ8, AAV2/Retro, AAV2/PHP.eB, AAV2/PHP.B, AAV2/rh10, AAV2/PHP.S, AAV2/anc80, AAV2/B10, AAV2/olig001, AAV2/BI30, AAV2/BR1, AAV2/MG1.2, AAV1/2, AAV2/MaCPNS1, and AAV2/MaCPNS2. Regular titer is greater than or equal to 2.00E+12 vg per mL, with high titer greater than or equal to 1.00E+13 vg per mL available upon request at no additional cost. Customers may specify preferred serotype and titer when placing orders.
BIOHIPPO AAV-D2-GCaMP6m-WPRE-hGH--polyA
Recombinant adeno associated virus expressing GCaMP6m under the D2 promoter with WPRE and hGH polyA elements. Offered under the Biohippo AAVX Series with multiple serotypes available including AAV2/1, AAV2/2, AAV2/5, AAV2/6, AAV2/6m, AAV2/6.2FF, AAV2/7m8, AAV2/8, AAV2/9, AAV2/DJ, AAV2/DJ8, AAV2/Retro, AAV2/PHP.eB, AAV2/PHP.B, AAV2/rh10, AAV2/PHP.S, AAV2/anc80, AAV2/B10, AAV2/olig001, AAV2/BI30, AAV2/BR1, AAV2/MG1.2, AAV1/2, AAV2/MaCPNS1, and AAV2/MaCPNS2. Regular titer is greater than or equal to 2.00E+12 vg per mL, with high titer greater than or equal to 1.00E+13 vg per mL available upon request at no additional cost. Customers may specify preferred serotype and titer when placing orders.
Medchemexpress LLC Betaine-d3 chloride | 1219349-47-9 | 156.63 | 5 MG
Betaine-d3 chloride is the deuterium labeled Betaine chloride. It is for research use only and not sold to patients.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Sigma Aldrich Fine Chemicals Biosciences 2 Keto 3 methyl d3 butyrc500MG
2 Keto 3 methyl d3 butyrc500MG
Cayman Chemical PentadecnoIc AcId-d3 10mg
An internal standard for the quantification of pentadecanoic acid by GC- or LC-MS
