Purine nucleosides
Medchemexpress LLC 6-Thio-2'-Deoxyguanosine | 789-61-7 | 99.7% | 283.31 | 50 MG
6-Thio-2'-Deoxyguanosine is a nucleoside analogue that can be incorporated into de novo-synthesized telomeres by telomerase. It causes rapid cell death for the majority of cancer cell lines tested with IC50s between 0.7-2.9 μM. In A549 lung cancer cell-based mouse xenograft studies, it decreases tumor growth rate and increases telomere dysfunction in tumor cells in vivo.
- Nucleoside analogue
- Incorporated into de novo-synthesized telomeres by telomerase
- Results in rapid cell death for the vast majority of cancer cell lines tested with IC50s of between 0.7-2.9 μM
- Causes a decrease of the tumor growth rate in A549 lung cancer cell-based mouse xenograft studies
- Increases telomere dysfunction in tumor cells in vivo
Cambridge Isotope Laboratories 8-Hydroxy-2-deoxyguanosine (unlabeled) 25 ug/mL in water 1 2 mL
8-Hydroxy-2-deoxyguanosine (unlabeled) 25 ug/mL in water 1 2 mL
Sigma Aldrich Fine Chemicals Biosciences MCOPPB trihydrochloride hydrate >98% (HPLC) | Purity: >98% (HPLC) | 1028969-49-4 (free base) | 5MG
MCOPPB trihydrochloride hydrate >98% (HPLC) | Purity: >98% (HPLC) | 1028969-49-4 (free base) | 5MG
Medchemexpress LLC 2'-Deoxyguanosine-13C10,15N5 | 872624-05-0 | 282.13 | 1 MG
2'-Deoxyguanosine-13C10,15N5 is a 13C- and 15N-labeled 2'-Deoxyguanosine for research use only. This compound is used as a tracer or as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS. Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process, with deuteration showing potential to affect the pharmacokinetic and metabolic profiles of drugs.
- Used as a tracer
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC 6-Thio-2'-Deoxyguanosine | 789-61-7 | 99.7% | 283.31 | 100 MG
6-Thio-2'-Deoxyguanosine is a nucleoside analogue that can be incorporated into de novo-synthesized telomeres by telomerase. It causes rapid cell death in most tested cancer cell lines and decreases tumor growth rate in mouse xenograft models, increasing telomere dysfunction in tumor cells in vivo.
- Nucleoside analogue
- Can be incorporated into de novo-synthesized telomeres by telomerase
- Induces rapid cell death in cancer cell lines
- Decreases tumor growth rate in mouse xenograft models
- Increases telomere dysfunction in tumor cells in vivo
- DNA/RNA synthesis inhibitor
Bioworld 2'-Deoxyadenosine Monohydrate, 10 g
A deoxyribonucleoside, may be used by some cells as an energy source under energy stress conditions and to affect cAMP levels. It is used in comparison studies of the functions of adenosine analogues on various biological processes. Specifications:Ultra Pure GradeEM (259nm, phosphate buffer, pH 7.0): >14,500Appearance: White crystalline powderChEBI : Not available.Crystal_Structure : Not available.InChI : Not available.InChIKey : Not available.Melting Point: 187-189 °CRTECS Number: AU7358600
Apexbio Technology LLC Cordycepin 73-03-0 20mg
Cordycepin (73-03-0) is a small-molecule inhibitor targeting pro-inflammatory cytokines such as IL-1 IL-6 and TNF- It is designed to inhibit inflammatory signaling pathways thereby regulating immune and inflammatory responses Cordycepin exerts its biological activity primarily through interference with RNA synthesis by incorporation into RNA chains leading to premature termination and inhibition of protein translation In cell-based studies cordycepin demonstrates inhibitory activity with IC50 values in the low micromolar range (approximately 5-15 M) depending on experimental conditions and cell models Based on these pharmacological properties cordycepin holds research potential in inflammation regulation immune-response modulation tuberculosis infection modeling and RNA transcription studies
Medchemexpress LLC Deoxyguanosine triphosphate trisodium solution | 93919-41-6 | 99.95% | 573.13 | 57.31 MG
Deoxyguanosine triphosphate (dGTP) trisodium solution (100mM) is a nucleotide precursor in cells for DNA synthesis. It is used in reverse transcription-polymerase chain reaction (RT-PCR) for DNA amplification.
- Nucleotide precursor for DNA synthesis.
- Used in reverse transcription-polymerase chain reaction (RT-PCR) for DNA amplification.
- High purity: 99.95%.
eMolecules Broadpharm / N6-Bz-5-O-DMTr-3-deoxyadenosine-2-O-CED-phosphoramidite / 50mg / 784455704 / BP-40039 / / 207347-42-0 / MFCD00274762 / 857.949 / C47H52N7O7P
Broadpharm / N6-Bz-5-O-DMTr-3-deoxyadenosine-2-O-CED-phosphoramidite / 50mg / 784455704 / BP-40039 / / 207347-42-0 / MFCD00274762 / 857.949 / C47H52N7O7P
Medchemexpress LLC 2'-Deoxyadenosine monohydrate | 16373-93-6 | 99.89% | 269.26 | 5 G
2'-Deoxyadenosine monohydrate is an adenine nucleoside with multiple biological roles, including inhibiting glucose-stimulated insulin release and islet cyclic AMP (cAMP) accumulation. It activates caspase-3 and promotes apoptosis, and inhibits S-adenosyl-L-homocysteine hydrolase (SAHH) activity. It has shown an anticancer effect on colon cancer and appears as a white to off-white solid.
- Inhibits glucose-stimulated insulin release
- Inhibits glucose-stimulated increases in islet cyclic AMP (cAMP) accumulation
- Activates caspase-3
- Promotes apoptosis
- Inhibits S-adenosyl-L-homocysteine hydrolase (SAHH) activity
- Demonstrated inhibitory effect on the growth of various cells, including anticancer effect on colon cancer
- Appears as a white to off-white solid
Medchemexpress LLC N6-Ethyladenosine | 14357-08-5 | 99.9% | 295.29 | 1 ML
N6-Ethyladenosine is an adenosine derivative that functions as an Adenosine receptor agonist, with Ki values of 4.9 nM and 4.7 nM for hA1AR and hA3AR, respectively. It exhibits higher selectivity for hA1AR and hA3AR compared to hA2AR (Ki, 8900±770 nM).
- Adenosine receptor agonist
- High selectivity for hA1AR and hA3AR over hA2AR
- Available in solid and solution forms
- Available for bulk inquiry
- Supported by research publications
Alkali Scientific 2' Deoxyguanosine monohydrate, 5 Grams
2'-Deoxyguanosine Monohydrate is a nucleoside involved in DNA replication and repair processes. It is a critical component of nucleic acids, particularly in the synthesis of the DNA molecule where it pairs with cytosine. This reagent is commonly used in molecular biology and biochemistry applications, including DNA synthesis, sequencing, and polymerase chain reactions (PCR). The 5-gram quantity is ideal for labs performing high-throughput DNA synthesis, sequencing, and various genetic studies. It is an essential component for laboratories working with nucleic acids, particularly in the synthesis of oligonucleotides and the study of nucleotide incorporation into DNA sequences.
Cambridge Isotope Laboratories 8-Hydroxy-2-deoxyguanosine (15N5 98%) 25 ug/mL in water 1 2 mL
8-Hydroxy-2-deoxyguanosine (15N5 98%) 25 ug/mL in water 1 2 mL