Drug Standards
Echelon Biosciences Research Labs PIK-93 5 mg
PIK-93 is the first reported PI4-kinase inhibitor, which is able to inhibit PI4KIII at low-nanomolar range (IC50=19 nM). In addition, this compound is a potent inhibitor of PI3K in vitro (IC50=16 nM). This compound inhibits p110, p110, p110 with IC50s of 0.039, 0.59, 0.12 M respectively. PIK-93 hydrogen bonds to the backbone amide and carbonyl of Val882 and between its sulphonamide and Asp964. PI4KIII is esential for replication of numerous viruses P. falciparum. Inhibition of plasmodial PI4KIII has been proposed as an anti-malaria treatment. This item is non returnable
Medchemexpress LLC Mogroside VI B | 2149606-17-5 | 1 MG
Mogroside VI B is a cucurbitane glucoside separated from the crude extract of Siraitia grosvenorii. It shows an effect on activating PGC-1α transcription.
- Separated from the crude extract of Siraitia grosvenorii
- Activates PGC-1α transcription
- Shows moderate effects on PGC-1α promoter activity
- Exhibits PGC-1α promoter activity at 20 μM
Medchemexpress LLC Dacomitinib impurity 9 | 2117703-26-9 | 50mg
Dacomitinib impurity 9 is an impurity of Dacomitinib (HY-13272)
![Medchemexpress LLC N-[3-[[5-chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]thio]phenyl]-2-propenamide | 1214265-57-2 | 99.2% | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000234411.png-250.jpg)
Medchemexpress LLC N-[3-[[5-chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]thio]phenyl]-2-propenamide | 1214265-57-2 | 99.2% | 5 MG
WZ8040 is an irreversible, mutant-selective inhibitor of the epidermal growth factor receptor (EGFR) with activity against the T790M resistance mutation. It inhibits EGFR phosphorylation and is used as a laboratory research compound to study mutant EGFR signaling and inhibitor sensitivity.
- Irreversible inhibitor of EGFR T790M.
- Demonstrates substantially greater potency against mutant EGFR compared with wild-type.
- Available as solid powder and as DMSO solutions for ready-to-use applications.
- Typical purity around 99.2% as supplied.
- Soluble in DMSO (high solubility reported) and formulatable for in vivo dosing protocols.
- Store powder at -20°C for long-term stability; store stock solutions at -80°C when possible.
- Intended for research use only; not for human or veterinary use.
Medchemexpress LLC Methylprednisolone | 83-43-2 | >99.8% | 2 G
Methylprednisolone | 83-43-2 | >99.8% | 2 G
Medchemexpress LLC Diltiazem (hydrochloride) | 33286-22-5 | 99.47% | 450.98 | 1 ML
Diltiazem hydrochloride is a Ca2+ influx inhibitor, also known as a slow channel blocker or calcium antagonist. Intended for research use only, this benzothiazepine Ca2+ antagonist interacts with transmembrane segments IIIS6 and IVS6 in the α1 subunit of L-type Ca2+ channels. It causes a dose-dependent inhibition of contractions and Ca2+ influx stimulated by alpha adrenoceptor activation and high-K+ depolarization.
- Ca2+ influx inhibitor
- Slow channel blocker or calcium antagonist
- Interacts with transmembrane segments IIIS6 and IVS6 in the α1 subunit of L-type Ca2+ channels
- Causes dose-dependent inhibition of contractions and Ca2+ influx
- Inhibits Na-dependent Ca-efflux from heart mitochondria
- Improves cardiac microcirculation and function in hyperthyroid rats
- Decreases blood pressure and increases heart rate in hypertensive rats
- L-type calcium channel is the IC50 target
U.S. Pharmacopeia IBUTILIDE RELATED COMP B 20MG
Ibutilide Related Compound B (20 mg) (N-Ethyl-N-heptyl-4-hydroxy-4-[4-(methylsulfonamido)phenyl]butanamide)
Medchemexpress LLC Diclofenac (diethylamine) | 78213-16-8 | C18H22Cl2N2O2 | 5 G
Diclofenac diethylamine is a potent and nonselective anti-inflammatory agent that acts as a COX inhibitor. It has IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively. Additionally, it induces apoptosis of neural stem cells (NSCs) by activating the caspase cascade.
- Potent and nonselective anti-inflammatory agent: acts as a COX inhibitor.
- Target specificities: IC50s of 4 nM for human COX-1 and 1.3 nM for human COX-2 in CHO cells.
- Ovine COX inhibition: IC50s of 5.1 μM for ovine COX-1 and 0.84 μM for ovine COX-2.
- Apoptosis induction: induces apoptosis of neural stem cells (NSCs) via activation of the caspase cascade.
- Available in 5 G variant.
Chem-Impex International, Inc. Gabapentin | 60142-96-3 | MFCD00865286 | 25G
Gabapentin, 60142-96-3, MFCD00865286, 25G
Selleck Chemical LLC Clevudine S3001-50mg
Clevudine(Levovir L-FMAU) is an antiviral drug for the treatment of hepatitis B