Drug Standards
Echelon Biosciences Research Labs ETHER C18 LBPA 500 ug
Ether C18 Lysobisphosphatidic acid ((S,S)-2,2-Bisoctadecyl-LBPA ammonium salt) is an ether analog of the naturally occurring, biologically active isomer of LPBA.Lysobisphosphatidic acids (LBPAs), known also as bis-(monoacylglycerol)phosphates (BMPs) are specialized lipids reported to play a role in intracellular protein and lipid transport in healthy cells. Their accumulation was observed in pathologic liver tissue, and they also serve as antigens for auto-antibody generation in a human autoimmune condition termed antiphospholipid syndrome. Accumulation of LBPAs in intracellular, often multilamellar membranes is related to biomembrane polymorphism which may impact intracellular cholesterol transport. This item is non returnable
Medchemexpress LLC Diaveridine | 5355-16-8 | MFCD00057349 | 99.8% | 5 G
Diaveridine is a dihydrofolate reductase (DHFR) inhibitor with a Ki of 11.5 nM for the wild type DHFR and also an antibacterial agent. It is intended for research use only.
- Dihydrofolate reductase (DHFR) inhibitor with a Ki of 11.5 nM
- Functions as an antibacterial agent
- Exhibits strong bactericidal effect on S. typhimurium TA1535 at 10 μg/mL or more
- Causes a dose-dependent, significant increase in aberrant metaphases at 100 μg/mL
- Does not cause abnormal chromosome aberration at studied doses
- Does not produce significant changes in organ-to-body weight ratio
Medchemexpress LLC Palbociclib impurity 20 | 1774898-55-3 | 99.9% | 308.34 | 5 MG
Palbociclib impurity 20 is an impurity of Palbociclib (HY-50767). It has a CAS No. of 1774898-55-3 and a Molecular Weight of 308.34. The chemical formula is C14H20N4O4 and it appears as a solid.
- High purity for reliable research
- Shipped at room temperature in continental US
- Powder can be stored at -20°C for 3 years or 4°C for 2 years
- In solvent, store at -80°C for 6 months or -20°C for 1 month
Medchemexpress LLC Ruxolitinib phosphate | 1092939-17-7 | MFCD18452860 | 99.97% | C17H21N6O4P | 200 MG
Ruxolitinib phosphate (INCB018424 phosphate) is a potent JAK1/2 inhibitor with IC50s of 3.3 nM for JAK1 and 2.8 nM for JAK2, demonstrating over 130-fold selectivity compared to JAK3. It potently and selectively inhibits JAK2V617F-mediated signaling and proliferation in vitro, inhibiting the growth of HEL cells with an EC50 of 186 nM and increasing apoptosis in Ba/F3-EpoR-JAK2V617F cells.
- Potent and selective JAK1/2 inhibitor
- Inhibits JAK2V617F-mediated signaling and proliferation
- Increases apoptosis in specific cell systems
- Inhibits hematopoietic progenitor cell proliferation in MPN patient samples
Cayman Chemical Montelukast sodium salt
A CysLT1 receptor antagonist (IC50 = 4.9 nM in HEK293 cell membranes expressing the human receptor); selective for CysLT1 over CysLT2 receptors (IC50 = >10,000 nM in COS-7 cell membranes expressing the human receptor); inhibits LTD4-induced bronchoconstriction in anesthetized guinea pigs (ED50 = 69 nmol/kg, p.o.); inhibits ovalbumin-induced airway hyperresponsiveness and increases in the number of total cells and eosinophils in BALF in a mouse model of allergic asthma at 3 and 10 mg/kg
Cayman Chemical Zileuton Neurochemicals
A reversible 5-LO inhibitor; inhibits 5-LO activity in RBL-1 cell supernatant (IC50 = 0.5 µM); inhibits LTB4 production induced by A23187 in purified human PMNLs (IC50 = 0.6 µM); prevents antigen challenge-induced increases in specific lung resistance in a sheep model of asthma at 4 to 8 hours post-challenge at 10 mg/kg, p.o., 2 hours pre-challenge
Cayman Chemical Losartan potassium salt
An AT1b antagonist (IC50 = 2.2 nM in COS-7 cells expressing the rat receptor); reduces U-46619-induced aggregation of platelets in isolated human platelet-rich plasma at 5 µM; decreases 1-LO levels in the endothelial layer of autologous vein grafts in rabbits fed a high-cholesterol diet at 10 mg/kg per day; decreases systolic blood pressure in a ouabain-induced mouse model of hypertension at 15 mg/kg per day; increases the mechanical pain threshold in the von Frey test in a paclitaxel-induced rat model of neuropathic pain at 50 mg/kg twice per day
Abcam 25-Hydro x yvitamin D3 (Calcifediol), metabolite of vitamin D3, 5MG
MW 400.6 Da, Purity >98%. Principal cholecalciferol (ab143594) metabolite. Downregulates TLR4 and JAK1/STAT3 signaling. Hydroxylates to calcitriol (ab141456) *in vivo*. Anti-inflammatory effects. Orally active.
The product is subject to the following: Abcam Restricted Use Statement
Medchemexpress LLC Naftifine (hydrochloride) | 65473-14-5 | 99.7% | 1 ML
Naftifine hydrochloride is an antibiotic with antifungal activity against dermatophytes, aspergilli, *Sporothrix schenckii*, and yeasts of the genus *Candida*. It is utilized for research into the inhibition of superficial dermatomycoses.
- Antibiotic with antifungal activity
- Effective against dermatophytes, aspergilli, *Sporothrix schenckii*, and *Candida* species
- Utilized for research into inhibition of superficial dermatomycoses
- Exhibits spectrum of activity with minimal inhibitory concentrations (MICs) against various fungi
- For research use only
Medchemexpress LLC Triamcinolone (Standard) | 124-94-7 | MFCD00010477 | 98.02% | 100 MG
Triamcinolone (Standard) is an analytical reference standard used for research and analytical applications. This product is suitable for qualitative, quantitative, and methodological research experiments including HPLC, GC, and MS.
- Intended for research and analytical applications
- Used as an analytical standard
- Suitable for qualitative research experiments
- Suitable for quantitative research experiments
- Suitable for methodological research experiments
- Compatible with HPLC
- Compatible with GC
- Compatible with MS