Drug Standards
Chem-Impex International, Inc. Cefazolin Sodium | 27164-46-1 | MFCD00056883 | 1G
Cefazolin Sodium, 27164-46-1, MFCD00056883, 1G
Medchemexpress LLC Ranitidine | 66357-35-5 | MFCD00081180 | 99.9% | 1 ML
Ranitidine is a potent, selective, and orally active histamine H2-receptor antagonist. It effectively inhibits gastric secretion and antagonizes histamine-induced increases in guinea-pig isolated rat atrium and relaxations of the rat isolated uterine horn. Research indicates its potential in inhibiting breast tumor development and spread in mice, as well as reducing CD11b+Ly6Chi cells and lung metastasis.
- Potent, selective, and orally active histamine H2-receptor antagonist
- Inhibits gastric secretion
- Antagonizes Histamine-induced effects in isolated heart and uterine horn
- Inhibits breast tumor development and spread
- Reduces CD11b+Ly6Chi cells and inhibits lung metastasis
- Inhibits primary tumor growth
- Increases the latency of breast tumorigenesis and reduces tumor numbers
Apexbio Technology LLC Methylprednisolone(Synonyms: Medrol, Depo-Medrol, Solu-Medrol, Advantan, Urbason, Metipred, Medrate, Metilprednisolone), 10mM (in 1mL DMSO), CAS: 83-43-2.
Methylprednisolone (CAS 83-43-2) is a synthetic glucocorticoid receptor agonist that exerts anti-inflammatory effects by inhibiting pro-inflammatory cytokines notably TNF- and modulating NF- B signaling pathways In vitro studies demonstrate that methylprednisolone reduces TNF production and enhances IL-10 synthesis in mouse macrophages upon LPS stimulation suppresses chemokine secretion from human peripheral blood mononuclear cells and inhibits acantholysis in skin cultures Animal models indicate that intravenous methylprednisolone administration attenuates inflammation decreases macrophage infiltration and tissue damage post-spinal cord injury Clinically methylprednisolone is investigated for therapeutic use in acute spinal cord injury severe vasculitis and lupus nephritis
Apexbio Technology LLC Enzastaurin (LY317615) 170364-57-5 10mM (in 1mL DMSO)
Enzastaurin (LY317615 CAS 170364-57-5) is an orally bioavailable ATP-competitive inhibitor selective for protein kinase C beta (PKC ) a member of the serine-threonine kinase family implicated in tumor growth and progression By inhibiting PKC (IC50 6 nM) enzastaurin decreases phosphorylation and signaling of downstream effectors including ribosomal protein S6 GSK3 and AKT In cellular assays enzastaurin reduces proliferation and induces apoptosis across diverse tumor types (e g colon cancer HCT-116 glioblastoma U87MG) In vivo studies demonstrate antitumor efficacy in xenograft models highlighting its utility for oncology research
Apexbio Technology LLC R788 disodium 1025687-58-4 5mg
R788 disodium (CAS 1025687-58-4) is a prodrug of the active metabolite R406 a selective inhibitor of spleen tyrosine kinase (Syk) Syk mediates signaling downstream of activated Fc and B-cell receptors (BCR) In vitro R406 suppresses constitutive and ligand-stimulated BCR signaling in diffuse large B-cell lymphoma (DLBCL) lines by inhibiting Syk autophosphorylation (SYK525/526) and associated phosphorylation of BLNK inducing apoptosis In vivo R788 reduces malignant B-cell proliferation and tumor progression in E -TCL1 mice Clinically R788 has shown utility in rheumatoid arthritis improving therapeutic response rates in phase II trials
eMolecules 496775-62-3 | Eltrombopag Olamine | Target Molecule | MFCD22380664 | 564.643 | C29H36N6O6 | 0.000 | NCCO.NCCO.CC1=NN(C(=O)\C1=N/Nc1cccc(-c2cccc(c2)C(O)=O)c1O)c1ccc(C)c(C)c1 | 2mg | 711635113
Eltrombopag Olamine | Target Molecule | 496775-62-3 | MFCD22380664 | 564.643 | C29H36N6O6 | 0.000 | NCCO.NCCO.CC1=NN(C(=O)\C1=N/Nc1cccc(-c2cccc(c2)C(O)=O)c1O)c1ccc(C)c(C)c1 | 2mg | 711635113
Apexbio Technology LLC Salinomycin 53003-10-4 50mg
Salinomycin is a polyether ionophore antibiotic derived from Streptomyces albus with demonstrated antitumor activities against various cancer cell types It is proposed to function by disrupting multiple signaling pathways including Wnt/ -catenin signaling and interference with ABC drug transport proteins In vitro research on human hepatocellular carcinoma (HCC) cell lines HepG2 SMMC-7721 and BEL-7402 indicates antiproliferative effects with IC50 values of 7 7 M 13 7 M and 10 4 M respectively after 24-hour treatment Studies show that salinomycin induces cell cycle arrest apoptosis via increased Bax/Bcl-2 ratio reduces -catenin expression and elevates intracellular calcium concentrations In vivo assays using orthotopic liver cancer models corroborate its antiproliferative and pro-apoptotic activities suggesting utility in oncology research
Apexbio Technology LLC Betamethasone 378-44-9 10mM (in 1mL DMSO)
Betamethasone is a synthetic corticosteroid functioning primarily as a glucocorticoid receptor agonist Mechanistically it modulates gene expression through binding glucocorticoid receptors regulating transcription factors and subsequently affecting protein synthesis Betamethasone influences inflammatory pathways by inhibiting key enzyme expressions such as phospholipase A2 cyclooxygenase-2 (COX-2) and nitric oxide synthase (NOS) resulting in decreased synthesis of inflammatory mediators like prostaglandins leukotrienes and nitric oxide Additionally it has been reported to suppress keratinocyte proliferation Due to its glucocorticoid-modulating properties and anti-inflammatory effects betamethasone is commonly employed in biomedical research involving inflammatory signaling pathways dermatological models and gene expression studies
![eMolecules 1184-88-9 | Sodium pivalate | Oakwood Chemical | MFCD00064202 | 124.115 | C5H9NaO2 | 95.000 | [Na+].CC(C)(C)C([O-])=O | 250mg | 853685506](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000126929.jpg-250.jpg)
eMolecules 1184-88-9 | Sodium pivalate | Oakwood Chemical | MFCD00064202 | 124.115 | C5H9NaO2 | 95.000 | [Na+].CC(C)(C)C([O-])=O | 250mg | 853685506
Sodium pivalate | Oakwood Chemical | 1184-88-9 | MFCD00064202 | 124.115 | C5H9NaO2 | 95.000 | [Na+].CC(C)(C)C([O-])=O | 250mg | 853685506
Medchemexpress LLC Promazine hydrochloride | 53-60-1 | 99.9% | 1 ML
Promazine hydrochloride is an antipsychotic and a dopamine receptor D2 antagonist that inhibits dopaminergic neurotransmission. It is supplied as a solid, white to off-white powder.
- Antipsychotic and dopamine receptor D2 antagonist
- Inhibits dopaminergic neurotransmission
- Shows KDs of 25, 190, and 8400 nM at human norepinephrine, serotonin, and dopamine transporters
- Molecular weight: 320.88
- Chemical formula: C17H21ClN2S
- Soluble in water and DMSO at 100 mg/mL
Medchemexpress LLC Butylparaben (standard) | 94-26-8 | 98.9% | 100 MG
Butylparaben (Standard) is the analytical standard of Butylparaben. It is an organic compound used as an antimicrobial preservative in cosmetics, in active molecule suspensions, and as a food flavoring additive. This product is intended for research and analytical applications, particularly as a reference standard in qualitative, quantitative, and methodological research experiments using techniques like HPLC, GC, and MS.
- Analytical standard
- Used as an antimicrobial preservative in cosmetics
- Found in active molecule suspensions
- Used as a food flavoring additive
- Intended for research and analytical applications
- Reference standard for qualitative, quantitative, and methodological research
- Suitable for techniques such as HPLC, GC, and MS