Acetylides
Medchemexpress LLC Propargyl-PEG4-acid | 1415800-32-6 | 97.0% | 25 G
Propargyl-PEG4-acid is a PEG-based PROTAC linker used in the synthesis of BTK-IAP PROTACs, including Ibrutinib-based PROTAC 2 and its analogue PROTAC 3. PROTAC 3 has demonstrated BTK degradation with a DC50 of 200 nM in THP-1 cells. This compound also serves as a click chemistry reagent, featuring an Alkyne group for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. It is intended for research use only.
- PEG-based PROTAC linker
- Utilized in the synthesis of BTK-IAP PROTACs
- Functions as a click chemistry reagent
- Possesses an Alkyne group for copper-catalyzed azide-alkyne cycloaddition with azide-containing molecules
- Demonstrates BTK degradation in THP-1 cells
- Intended for research use only
STA PHARMACEUTICAL US LLC 2'-propargyl G(iBu) amidite | 5 g | CAS 171486-61-6 | MDL MFCD28976150
2'-propargyl G(iBu) amidite is a Amidite reagent (Subcategory: 2'-propargyl Series) sold by WuXi TIDES. Offered in 5 g. Store at -20 °C. SDS available for reference.
Specifications
- CAS: 171486-61-6
- MDL: MFCD28976150
- InChIKey: AGWGPRXHCUPJJO-VCGWOZLGSA-N
- Molecular Weight: 893.978761998
- Molecular Formula: C47H56N7O9P
- Purity: ≥95%
- Container Type: 100 mL Glass (Septum)
- Pack Size: 5 g
- Net Weight: 5 g
- Gross Weight: 100.4 g
- Commodity Code: 29349990
- Country Of Origin: China
- IUPAC: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-(prop-2-yn-1-yloxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
- SMILES: CC(N(P(O[C@H]1[C@H]([C@@H](O[C@@H]1COC(C2=CC=C(C=C2)OC)(C3=CC=C(C=C3)OC)C4=CC=CC=C4)N5C(N=C(N6)NC(C(C)C)=O)=C(N=C5)C6=O)OCC#C)OCCC#N)C(C)C)C
Medchemexpress LLC 4,7,10,13,16,19,22-heptaoxapentacos-24-ynoic acid | 2093154-00-6 | >98.0% | 392.44 g/mol | C18H32O9 | 25 MG
Propargyl-PEG7-acid is a PEG-based linker bearing a terminal propargyl (alkyne) group used for click chemistry, PROTAC assembly, and antibody-drug conjugate (ADC) synthesis. It is supplied as a light yellow liquid of high purity suitable for research bioconjugation workflows.
- Contains a terminal alkyne for copper-catalyzed azide-alkyne cycloaddition (CuAAC).
- Suitable for PROTAC and ADC linker synthesis.
- High purity (≥98.0%), compatible with analytical workflows.
- Light yellow liquid form, convenient for solution-phase conjugation.
- Available in small-scale and bulk pack sizes for synthesis needs.
Medchemexpress LLC Propargyl-PEG4-CH2COOH | 1429934-37-1 | ≥97.0% | 290.31 | 250 MG
Propargyl-PEG4-CH2COOH is a PEG-based PROTAC linker that is utilized in the synthesis of PROTACs. This compound also serves as a click chemistry reagent, featuring an Alkyne group capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains an alkyne group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc)
Medchemexpress LLC Propargyl-PEG1-Boc | 488150-84-1 | 97.0% | 184.23 | 500 MG
Propargyl-PEG1-Boc is an alkyl/ether-based PROTAC linker. It is used in the synthesis of PROTACs and functions as a click chemistry reagent due to its Alkyne group. This enables it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. It is for research use only, not for sale to patients.
- Click chemistry reagent
- Contains an alkyne group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Used in PROTAC synthesis
- Alkyl/ether-based PROTAC linker
- Suitable for cancer targeted therapy research
Medchemexpress LLC Propargyl-PEG5-OH | 1036204-60-0 | 97.0% | 250 MG
Propargyl-PEG5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
- It is a click chemistry reagent containing an Alkyne group.
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Medchemexpress LLC α-D-Glucopyranoside, β-D-fructofuranosyl O-α-D-galactopyranosyl-(1→6)-, hydrate (1:5) | 17629-30-0 | 594.51 | 1 ML
D(+)-Raffinose pentahydrate is an orally active inhibitor of LecA and GtfC. It reduces cyclic diguanylate (c-di-GMP) by increasing the activity of a c-di-GMP specific phosphodiesterase. This compound interferes with GTF function, decreases IL-4 and IL-5 mRNA, and inhibits allergic airway eosinophilia.
- Exhibits biofilm-inhibitory activity against Pseudomonas aeruginosa.
- Exhibits biofilm-inhibitory activity against Streptococcus mutans.
- Suppresses biofilm formation and reduces insoluble glucan production in Streptococcus mutans.
- Downregulates gtfB and gtfC gene expression.
- Alleviates allergen-induced airway eosinophilia in rats.
- Reduces IL-4 and IL-5 mRNA levels in lung tissue.
- Tends to lower alveolar macrophages, neutrophils, lymphocytes, and IgE levels.
eMolecules 2093153-98-9 | Propargyl-PEG9-amine | Broadpharm | MFCD30527387 | 451.557 | C21H41NO9 | 95.000 | NCCOCCOCCOCCOCCOCCOCCOCCOCCOCC#C | 1g | 336613438
Propargyl-PEG9-amine | Broadpharm | 2093153-98-9 | MFCD30527387 | 451.557 | C21H41NO9 | 95.000 | NCCOCCOCCOCCOCCOCCOCCOCCOCCOCC#C | 1g | 336613438
![Medchemexpress LLC Ethanamine, 2-[2-(2-propyn-1-yloxy)ethoxy]- | 944561-44-8 | 99.6% | 143.18 | C7H13NO2 | 1 G](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000203119.png-250.jpg)
Medchemexpress LLC Ethanamine, 2-[2-(2-propyn-1-yloxy)ethoxy]- | 944561-44-8 | 99.6% | 143.18 | C7H13NO2 | 1 G
Propargyl-PEG2-amine is a short PEG2-based linker containing a terminal propargyl (alkyne) group and a primary amine for bioconjugation. It is supplied as a colorless to light yellow liquid and is used as an ADC linker, PROTAC linker, and general crosslinking building block for click-type chemistries.
- Contains a terminal propargyl functional group for click reactions.
- Provides a short, flexible PEG2 spacer between functional groups.
- Features a primary amine for coupling to carboxyl or activated esters.
- Supplied as a colorless to light yellow liquid for easy handling.
- Molecular weight 143.18 and CAS number 944561-44-8 for unambiguous identification.
Medchemexpress LLC N-(Propargyl-PEG4)-biocytin | 2055042-71-0 | 98.0% | C28H46N4O9S | 100 MG
N-(Propargyl-PEG4)-biocytin is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, featuring an alkyne group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups. This product is intended for research use only.
- Molecular weight: 614.75
- Purity: 98.0%
- Appearance: Solid
- Color: Light yellow to light brown
- PEG-based PROTAC linker
- Functions as a click chemistry reagent
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc)
![eMolecules 22287-32-7 | (BICYCLO[1.1.1]PENT-1-YL)METHANOL | AstaTech | MFCD28040494 | 98.145 | C6H10O | 95.000 | OCC12CC(C1)C2 | 0.5g | 449779784](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000159132.jpg-250.jpg)
eMolecules 22287-32-7 | (BICYCLO[1.1.1]PENT-1-YL)METHANOL | AstaTech | MFCD28040494 | 98.145 | C6H10O | 95.000 | OCC12CC(C1)C2 | 0.5g | 449779784
(BICYCLO[1.1.1]PENT-1-YL)METHANOL | AstaTech | 22287-32-7 | MFCD28040494 | 98.145 | C6H10O | 95.000 | OCC12CC(C1)C2 | 0.5g | 449779784
Medchemexpress LLC Propargyl-PEG1-Boc | 488150-84-1 | 97.0% | 184.23 | 100 MG
Propargyl-PEG1-Boc is an alkyl/ether-based PROTAC linker, a click chemistry reagent, utilized in the synthesis of PROTACs. It contains an Alkyne group enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules possessing Azide groups.
- Used as a PROTAC linker for synthesizing PROTACs.
- Functions as a click chemistry reagent.
- Contains an Alkyne group for CuAAc reactions.
- Enables reactions with molecules possessing Azide groups.
- Supports the PROTAC mechanism of action, which involves the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
eMolecules 1092461-24-9 | 5-Chloro-2-(trifluoromethoxy)phenol | Apollo Scientific | MFCD11519363 | 212.550 | C7H4ClF3O2 | 97.000 | Oc1cc(Cl)ccc1OC(F)(F)F | 1g | 562454745
5-Chloro-2-(trifluoromethoxy)phenol | Apollo Scientific | 1092461-24-9 | MFCD11519363 | 212.550 | C7H4ClF3O2 | 97.000 | Oc1cc(Cl)ccc1OC(F)(F)F | 1g | 562454745
Medchemexpress LLC Propargyl-PEG5-NHS ester | 1393330-40-9 | 98.0% | 401.41 g/mol | C18H27NO9 | 250 MG
Propargyl-PEG5-NHS ester is an alkyne-terminated, amine-reactive PEG5 NHS ester used for bioconjugation and click chemistry. The NHS ester reacts with primary amines to form stable amide bonds, while the propargyl (alkyne) group enables copper-catalyzed azide-alkyne cycloaddition (CuAAC), making it suitable for linker incorporation in antibody-drug conjugates and PROTAC synthesis.
- Amine-reactive NHS ester for stable amide formation.
- Alkyne (propargyl) handle for copper-catalyzed click chemistry.
- PEG5 spacer provides hydrophilicity and conformational flexibility.
- High purity suitable for research-grade bioconjugation.
- Available in milligram to gram pack sizes for method development.
Chem-Impex International, Inc. (2-Hydroxyethyl)acetylene | 927-74-2 | MFCD00002955 | 25G
(2-Hydroxyethyl)acetylene, 927-74-2, MFCD00002955, 25G