Acetylides
Medchemexpress LLC Propargyl-PEG1-acid | 55683-37-9 | 97.0% | 5 G
Propargyl-PEG1-acid is a PEG-based PROTAC linker, utilized in the synthesis of BTK-CRBN PROTACs, including Ibrutinib-based PROTAC 4 and PROTAC 5. PROTAC 5 is known to degrade BTK and induce degradation of CSK, LYN, and LAT2. This compound also functions as a click chemistry reagent, featuring an alkyne group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. BTK-CRBN PROTACs are stoichiometric degraders, facilitating BTK protein degradation through the recruitment of cereblon E3 ligases.
- Peg-based PROTAC linker
- Used in synthesis of BTK-CRBN PROTACs
- Functions as a click chemistry reagent
- Features an alkyne group for CuAAc reactions
- Degrades BTK protein
- Induces degradation of CSK, LYN, and LAT2
Medchemexpress LLC VQW-765 (AQW-051) | 669770-29-0 | 99.58% | 294.39 | 5 MG
VQW-765 (AQW-051) is a selective and orally active alpha-7 nicotinic acetylcholine receptor (α7-nAChR) agonist. It demonstrates a pKD value of 7.56 to recombinantly expressed human α7-nAChR and exhibits anxiolytic-like effects in vivo. This compound can be used for research into anxiety disorder and acute performance anxiety.
- Selective and orally active alpha-7 nicotinic acetylcholine receptor (α7-nAChR) agonist
- Demonstrates potent agonist activity to calcium transients
- Enhances cognitive effect and learning/memory performance
- Shows anxiolytic-like effects in vivo
Medchemexpress LLC Propargyl-PEG1-Boc | 488150-84-1 | 97.0% | 184.23 | 250 MG
Propargyl-PEG1-Boc is an alkyl/ether-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. PROTACs are composed of two different ligands connected by a linker; one targets an E3 ubiquitin ligase and the other targets a specific protein, utilizing the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Alkyl/ether-based PROTAC linker
- Used in PROTAC synthesis
- Functions as a click chemistry reagent
- Contains an alkyne group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Utilizes the ubiquitin-proteasome system for targeted protein degradation
Medchemexpress LLC Propargyl-PEG10-acid | 2055022-18-7 | 98.0% | 524.60 | 100 MG
Propargyl-PEG10-acid is a PEG derivative featuring a propargyl group and a terminal carboxylic acid. It serves as a click chemistry reagent, utilizing an Alkyne group to engage in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules containing Azide groups. For research use only.
- PEG derivative with propargyl and terminal carboxylic acid groups
- Functions as a click chemistry reagent
- Contains an Alkyne group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions
- Reacts with molecules possessing Azide groups
Medchemexpress LLC Propargyl-PEG4-acid | 1415800-32-6 | 97.0% | 25 G
Propargyl-PEG4-acid is a PEG-based PROTAC linker used in the synthesis of BTK-IAP PROTACs, including Ibrutinib-based PROTAC 2 and its analogue PROTAC 3. PROTAC 3 has demonstrated BTK degradation with a DC50 of 200 nM in THP-1 cells. This compound also serves as a click chemistry reagent, featuring an Alkyne group for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. It is intended for research use only.
- PEG-based PROTAC linker
- Utilized in the synthesis of BTK-IAP PROTACs
- Functions as a click chemistry reagent
- Possesses an Alkyne group for copper-catalyzed azide-alkyne cycloaddition with azide-containing molecules
- Demonstrates BTK degradation in THP-1 cells
- Intended for research use only
STA Pharmaceutical 2'-propargyl G(iBu) amidite | 1 g | CAS 171486-61-6 | MDL MFCD28976150
2'-propargyl G(iBu) amidite is a Amidite reagent (Subcategory: 2'-propargyl Series) sold by WuXi TIDES. Offered in 1 g. Store at -20 °C. SDS available for reference.
Specifications
- CAS: 171486-61-6
- MDL: MFCD28976150
- InChIKey: AGWGPRXHCUPJJO-VCGWOZLGSA-N
- Molecular Weight: 893.978761998
- Molecular Formula: C47H56N7O9P
- Purity: ≥95%
- Container Type: 30 mL Glass (28-400)
- Pack Size: 1 g
- Net Weight: 1 g
- Gross Weight: 50.1 g
- Commodity Code: 29349990
- Country Of Origin: China
- IUPAC: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-(prop-2-yn-1-yloxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
- SMILES: CC(N(P(O[C@H]1[C@H]([C@@H](O[C@@H]1COC(C2=CC=C(C=C2)OC)(C3=CC=C(C=C3)OC)C4=CC=CC=C4)N5C(N=C(N6)NC(C(C)C)=O)=C(N=C5)C6=O)OCC#C)OCCC#N)C(C)C)C
eMolecules 106-96-7 | Propargyl bromide (80% wt.in toluene) contains 0.3% magnesium oxide as stabilizer | Oakwood Chemical211.102 | C10H11Br | 0.000 | BrCC#C.Cc1ccccc1 | 100g | 537712117
Propargyl bromide (80% wt.in toluene) contains 0.3% magnesium oxide as stabilizer | Oakwood Chemical | 106-96-7211.102 | C10H11Br | 0.000 | BrCC#C.Cc1ccccc1 | 100g | 537712117
Accela Chembio Inc MF: C7H5N | MW: 103.12 | >97% | Flash Point: 76 celsius | BP: 90¿C/30mmHg | Density: 1.0190.
MF: C7H5N | MW: 103.12 | >97% | Flash Point: 76 celsius | BP: 90¿C/30mmHg | Density: 1.0190.
Medchemexpress LLC Propargyl-PEG2-bromi 100mg
Propargyl-PEG2-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1] Propargyl-PEG2-bromide is a click chemistry reagent it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups
eMolecules 870822-78-9 | 5-Chloro-2-(trifluoromethoxy)phenylboronic acid | Combi-Blocks | MFCD10697424 | 240.370 | C7H5BClF3O3 | 96.000 | OB(O)c1cc(Cl)ccc1OC(F)(F)F | 1g | 117529394
5-Chloro-2-(trifluoromethoxy)phenylboronic acid | Combi-Blocks | 870822-78-9 | MFCD10697424 | 240.370 | C7H5BClF3O3 | 96.000 | OB(O)c1cc(Cl)ccc1OC(F)(F)F | 1g | 117529394
Medchemexpress LLC Propargyl-PEG3-NHS ester | 1428629-71-3 | MFCD23726610 | 97.0% | 313.30 g/mol | C14H19NO7 | 100 MG
Propargyl-PEG3-NHS ester is an NHS-activated PEG3 linker bearing a terminal propargyl (alkyne) group used for bioconjugation and linker synthesis. It couples to primary amines to form amide bonds and enables click chemistry via CuAAC.
- Reactive NHS ester for selective coupling to primary amines.
- Terminal alkyne enables copper-catalyzed azide-alkyne cycloaddition (CuAAC).
- Three-unit PEG spacer improves solubility and flexibility.
- High purity (97.0% by NMR) suitable for research applications.
- Soluble in DMSO; store under nitrogen at -20°C for stability.