Hydrocarbon derivatives
Medchemexpress LLC NB-598 hydrochloride | 136719-25-0 | 486.13 | 50 MG
NB-598 hydrochloride is a potent and competitive inhibitor of squalene epoxidase (SE), which suppresses triglyceride biosynthesis through the farnesol pathway. It is also a click chemistry reagent, containing an Alkyne group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Potent and competitive inhibitor of squalene epoxidase (SE).
- Suppresses triglyceride biosynthesis via the farnesol pathway.
- Functions as a click chemistry reagent, featuring an Alkyne group.
- Can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with Azide-containing molecules.
Medchemexpress LLC NB-598 | 131060-14-5 | 449.67 | 25 MG
NB-598 is a potent and competitive inhibitor of squalene epoxidase (SE) that suppresses triglyceride biosynthesis through the farnesol pathway. This compound also functions as a click chemistry reagent, featuring an alkyne group capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules.
- Potent and competitive inhibitor of squalene epoxidase
- Suppresses triglyceride biosynthesis
- Click chemistry reagent for copper-catalyzed azide-alkyne cycloaddition
- Suitable for immunology and inflammation research pathways
- Powder storage at -20°C for 3 years
- In solvent storage at -80°C for 6 months or -20°C for 1 month
Medchemexpress LLC NB-598 | 131060-14-5 | 449.67 | 100 MG
HY-16343, also known as NB-598, is identified as a potent and competitive inhibitor of squalene epoxidase (SE). It functions by suppressing triglyceride biosynthesis via the farnesol pathway. Furthermore, NB-598 serves as a click chemistry reagent, featuring an Alkyne group that enables it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules containing Azide groups.
- Potent and competitive inhibitor of squalene epoxidase (SE).
- Suppresses triglyceride biosynthesis through the farnesol pathway.
- Functions as a click chemistry reagent.
- Contains an alkyne group.
- Capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules.
Medchemexpress LLC 9-Decyn-1-ol | 17643-36-6 | 50 G
9-Decyn-1-ol is an alkyl/ether-based PROTAC linker used in the synthesis of PROTACs. It can conjugate GDC-0068 with Lenalidomide to create INY-03-041, a potent, highly selective, and PROTAC-based pan-Akt degrader. INY-03-041 inhibits Akt1, Akt2, and Akt3 with IC50s of 2.0 nM, 6.8 nM, and 3.5 nM, respectively. It is also a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Alkyl/ether-based PROTAC linker
- Used in the synthesis of PROTACs
- Generates a potent, highly selective, PROTAC-based pan-Akt degrader
- Click chemistry reagent with an alkyne group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide groups
Medchemexpress LLC 9-Decyn-1-ol | 17643-36-6 | 100 G
9-Decyn-1-ol is an alkyl/ether-based PROTAC linker used in the synthesis of PROTACs. It can be employed to conjugate GDC-0068 with Lenalidomide, resulting in INY-03-041, a potent, highly selective, and PROTAC-based pan-Akt degrader. It also functions as a click chemistry reagent.
- Used in the synthesis of PROTACs
- Can conjugate GDC-0068 with Lenalidomide to create INY-03-041, a pan-Akt degrader
- Inhibits Akt1, Akt2, and Akt3 with IC50s of 2.0 nM, 6.8 nM, and 3.5 nM, respectively
- Click chemistry reagent containing an Alkyne group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups
Medchemexpress LLC NB-598 | 131060-14-5 | 98.7% | 449.67 | 5 MG
NB-598 is a potent and competitive inhibitor of squalene epoxidase (SE) and suppresses triglyceride biosynthesis through the farnesol pathway. It is also a click chemistry reagent containing an Alkyne group, enabling it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules that have Azide groups.
- Potent and competitive squalene epoxidase inhibitor.
- Suppresses triglyceride biosynthesis.
- Functions as a click chemistry reagent.
- Designed for research use only.
- Inhibits cholesterol biosynthesis in HepG2 cells with an IC50 of 0.02 μM.
- Reduces total cholesterol level in MIN6 cells by 36±7% at 10 μM.
- Decreases cholesterol from PM, ER, and SG by approximately 49%, 46%, and 48% respectively.
- Dose-dependently inhibits insulin secretion.
- Reduces ACAT activity.
- Suppresses the secretion of cholesterol and triacylglycerol from HepG2 cells.