Lignans and related compounds
Medchemexpress LLC Podophyllotoxin glucoside | 16481-54-2 | 576.55 | 5 MG
Podophyllotoxin glucoside is a podophyllotoxin derivative that has anti-tumor effects.
- Podophyllotoxin derivative
- Solid
- White to off-white color
- Has anti-tumor effects
TARGETMOL CHEMICALS INC PICROPODOPHYLLOTOXIN 25MG
Also available in 1 mg 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Picropodophyllotoxin (AXL 1717) is a cyclolignan alkaloid found in the mayapple plant family (Podophyllum peltatum) and a small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF1R) with potential antineoplastic activity. Picropodophyllotoxin (AXL 1717) specifically inhibits the activity and downregulates the cellular expression of IGF1R without interfering with activities of other growth factor receptors such as receptors for insulin epidermal growth factor platelet-derived growth factor fibroblast growth factor and mast/stem cell growth factor (KIT). This agent shows potent activity in the suppression o f tumor cell proliferation and the induction of tumor cell apoptosis. IGF1R a receptor tyrosine kinase overexpressed in a variety of human cancers plays a critical role in the growth and survival of many types of cancer cells. purity: 99%
Medchemexpress LLC Anthracene-9-carboxylic acid | 723-62-6 | MFCD00001257 | 222.24 g/mol | C15H10O2 | 500 MG
Anthracene-9-carboxylic acid is an anthracene derivative supplied as an analytical standard for research use. It is commonly used as a chloride current blocker in electrophysiology and as a reference material in analytical testing.
- Analytical standard grade for research applications.
- Molecular formula C15H10O2; molecular weight 222.24 g/mol.
- Used to block Ca2+-activated chloride currents in electrophysiology assays.
- Suitable as a reference standard for chromatographic and spectroscopic analyses.
- Available in multiple pack sizes, including 500 mg.
Medchemexpress LLC Etoposide phosphate | 117091-64-2 | 99.4% | 668.54 | 1 ML
Etoposide phosphate is a water-soluble derivative and prodrug of etoposide, functioning as a potent anti-cancer chemotherapy agent and a selective topoisomerase II inhibitor. It prevents re-ligation of DNA strands and induces cell cycle arrest, apoptosis, and autophagy, making it suitable for various research applications.
- Potent anti-cancer chemotherapy agent
- Selective topoisomerase II inhibitor
- Prevents re-ligation of DNA strands
- Induces cell cycle arrest, apoptosis, and autophagy
- Water-soluble derivative and probable prodrug of etoposide
- Inhibits HCT116 cell growth in a dose-dependent manner
Apexbio Technology LLC Etoposide 33419-42-0 10mM (in 1mL DMSO)
Etoposide (VP-16) is a topoisomerase II inhibitor widely used in biomedical research to study mechanisms of DNA damage and cancer therapy It forms a stabilized complex with DNA and topoisomerase II preventing the enzyme-mediated religation of cleaved DNA strands Resulting DNA double-strand breaks lead to apoptosis particularly in rapidly dividing cancer cells Reported IC50 values vary across cell lines such as 59 2 M for topoisomerase II inhibition 30 16 M in HepG2 and 0 051 M for MOLT-3 indicating differential cytotoxic responses to etoposide in various cancer cell models
Medchemexpress LLC N-demethyl ivabradine-d6 hydrochloride | 98.0% | 497.06 g/mol | C26H29D6ClN2O5 | 5 MG
N-Demethyl Ivabradine-d6 hydrochloride is the deuterium-labeled N-demethyl metabolite of ivabradine supplied as the hydrochloride salt. It is provided as a solid powder intended for use as an analytical standard or tracer in quantitative NMR, GC-MS, or LC-MS applications.
- Deuterium-labeled (d6) analogue for use as an internal standard.
- High purity (98.0%).
- Provided as a hydrochloride salt in solid powder form.
- Available in small analytical pack sizes suitable for assay development.
- Storage stability: powder -20°C (3 years) or 4°C (2 years).
- Suitable as a tracer and internal standard for quantitative analysis by NMR, GC-MS, and LC-MS.
Sigma Aldrich Fine Chemicals Biosciences Etoposide | 33419-42-0 | MFCD00869325 | 25 mg
Etoposide | Purity: 98.0-105.0% | Mol Wt: 588.56 | 33419-42-0 | MFCD00869325 | 25 mg
Apexbio Technology LLC Etoposide, 33419-42-0, MFCD00869325, 100 mg
MF: C29H32O13, MW: 588.56, Solubility: 29.45mg/mL in DMSO. Etoposide (VP-16) is the first agent recognized as a topoisomerase II inhibitor of anticancer drug with IC50 of 59.2 uM.