ATIC-IN-1 acetate, also referred to as compound 14, is a specific inhibitor targeting the dimerization of Aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC). This dimerization is critical for the AICAR transformylase activity of ATIC, an enzyme involved in de novo purine biosynthesis. It demonstrates anti-tumor activity by reducing cell numbers and cell division rates.
- Inhibits ATIC dimerization crucial for AICAR transformylase activity
- Ki value of 685 nM
- Exhibits anti-tumor activity by reducing cell numbers
- Reduces cell division rates
- Specific inhibitor at 10 μM and 50 μM
- Inhibits proliferation of MCF-7 cells at 100-500 μM over 48 hours