Hydrobromides
Medchemexpress LLC Halofuginone hydrobromide | 64924-67-0 | 495.59 | 500 MG
Halofuginone hydrobromide is a Febrifugine derivative and a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM. It is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibiting TGF-β activity. It also acts as a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated, and store-operated Ca2+ channels.
- Competitive prolyl-tRNA synthetase inhibitor (Ki of 18.3 nM).
- Specific inhibitor of type-I collagen synthesis.
- Attenuates osteoarthritis (OA) by inhibition of TGF-β activity.
- Potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated, and store-operated Ca2+ channels.
- Has anti-malaria, anti-inflammatory, anti-cancer, and anti-fibrosis effects.
Medchemexpress LLC Halofuginone (hydrobromide) | 64924-67-0 | 495.59 | 1 ML
Halofuginone hydrobromide (RU-19110 hydrobromide), a Febrifugine derivative, acts as a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM. It specifically inhibits type-I collagen synthesis and reduces osteoarthritis (OA) by inhibiting TGF-β activity. Additionally, it functions as a potent pulmonary vasodilator through the activation of Kv channels and the blocking of voltage-gated, receptor-operated, and store-operated Ca2+ channels.
- Competitive prolyl-tRNA synthetase inhibitor (Ki of 18.3 nM)
- Inhibits type-I collagen synthesis
- Reduces osteoarthritis (OA) by inhibiting TGF-β activity
- Potent pulmonary vasodilator through Kv channel activation
- Blocks voltage-gated, receptor-operated, and store-operated Ca2+ channels
- Exhibits anti-malaria, anti-inflammatory, anti-cancer, and anti-fibrosis effects
Medchemexpress LLC Eletriptan hydrobromide | 177834-92-3 | 99.8% | C22H27BrN2O2S | 25 MG
Eletriptan hydrobromide (Eletriptan HBr) is a 5-HT1B and 5-HT1D receptor agonist with antimigraine activity. It has Ki values of 0.92 nM for 5-HT1B receptors and 3.14 nM for 5-HT1D receptors.
- Dose-dependently reduces carotid blood flow in anesthetized dogs (1-1000 μg/kg; i.v.)
- Inhibits dural plasma protein extravasation in anesthetized rats (30-300 μg/kg; i.v.)
- Completely inhibits extravasation from the dura mater at 100 μg/kg
- Appears as an off-white to light brown solid
Medchemexpress LLC Oxidopamine hydrobromide | 636-00-0 | 99.42% | 100 MG
Oxidopamine (6-OHDA) hydrobromide is an antagonist of the neurotransmitter dopamine. It is a widely used neurotoxin that selectively destroys dopaminergic neurons. It promotes COX-2 activation, leading to PGE2 synthesis and pro-inflammatory cytokine IL-1β secretion. Oxidopamine hydrobromide can be used for the research of Parkinson's disease (PD), attention-deficit hyperactivity disorder (ADHD), and Lesch-Nyhan syndrome.
- Antagonist of the neurotransmitter dopamine.
- Widely used neurotoxin.
- Selectively destroys dopaminergic neurons.
- Promotes COX-2 activation.
- Leads to PGE2 synthesis and pro-inflammatory cytokine IL-1β secretion.
- Used for research of Parkinson's disease (PD), attention-deficit hyperactivity disorder (ADHD), and Lesch-Nyhan syndrome.
AdipoGen 2 3-Diaminopropane-1-thiol HBr
Chemical. CAS 70548-07-1. Formula C3H10N2S . 2HBr. MW 106.2 . 161.8. Synthetic Building block for synthesis.
Medchemexpress LLC Burixafor hydrobromide | 1191450-19-7 | 98.0% | 769.01 | C27H51N8O3P·5/2 HBr | 10 MG
Burixafor hydrobromide is the hydrobromide salt of burixafor, a selective, orally active CXCR4 antagonist supplied as a research reagent for preclinical and in vitro studies of CXCR4-mediated biology, including cancer metastasis, angiogenesis, and hematopoietic stem cell mobilization.
- Selective CXCR4 antagonist for receptor-targeted studies.
- High purity (98.0%) suitable for research applications.
- Water soluble (≈50 mg/mL) with ultrasonic assistance.
- Solid, light yellow to yellow appearance for easy handling.
- Recommended storage at -20°C under nitrogen for stability.
- Available in small research quantity (10 MG).
Medchemexpress LLC Oxidopamine (hydrobromide) | 636-00-0 | 99.4% | 50 MG
Oxidopamine (6-OHDA) hydrobromide is a neurotoxin that selectively destroys dopaminergic neurons and acts as an antagonist of the neurotransmitter dopamine. It promotes COX-2 activation, leading to PGE2 synthesis and pro-inflammatory cytokine IL-1β secretion. This compound is used in research for Parkinson's disease (PD), attention-deficit hyperactivity disorder (ADHD), and Lesch-Nyhan syndrome.
- Antagonist of the neurotransmitter dopamine.
- Selectively destroys dopaminergic neurons.
- Promotes COX-2 activation, leading to PGE2 synthesis and pro-inflammatory cytokine IL-1β secretion.
- Used for research of Parkinson's disease (PD), attention-deficit hyperactivity disorder (ADHD), and Lesch-Nyhan syndrome.
- Can induce Parkinson's disease models.
Medchemexpress LLC Fatostatin hydrobromide (125B11 hydrobromide) | 298197-04-3 | 99.5% | C18H19BrN2S | 200 MG
Fatostatin hydrobromide (125B11 hydrobromide) is a specific inhibitor of SREBP activation that impairs the activation of SREBP-1 and SREBP-2. It binds to SCAP (SREBP cleavage-activating protein) and inhibits the ER-Golgi translocation of SREBPs.
- Impairs the activation of SREBP-1 and SREBP-2
- Binds to SCAP (SREBP cleavage-activating protein)
- Inhibits ER-Golgi translocation of SREBPs
- Decreases transcription of lipogenic genes in cells
- Possesses antitumor properties
- Lowers hyperglycemia in ob/ob mice
- For research use only
TARGETMOL CHEMICALS INC PIFITHRIN-ALPHA HYDROBRO 25MG
Also available in 2 mg 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Pifithrin-(alpha) hydrobromide (Pifithrin-(alpha) hydrobromide) is a p53 inhibitor inhibiting p53-dependent transactivation of p53-responsive genes. purity: 98%
TARGETMOL CHEMICALS INC VORTIOXETINE HYDROBROMID 100MG
Also available in 10 mg 25 mg 50 mg 200 mg 500 mg 1000 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Vortioxetine hydrobromide (Lu AA21004 hydrobromide) is a serotonin (5-HT) modulator and stimulator (SMS) inhibits 5-HT1A/1B/3A/7 receptor and SERT (IC50 15/33/3.7/19/1.6 nM). purity: 99%
TARGETMOL CHEMICALS INC Immethridine dihydrobromide
Also available in 1 mg, 10 mg, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Immethridine dihydrobromide is a novel, highly potent and selective histamine H3 receptor (H3R) agonist that inhibits dendritic cell function and alleviates experimental autoimmune encephalomyelitis.Immethridine dihydrobromide MesV induces depolarization of neurons and the MMN and prevents cardiorenal and renal injury. injury. Purity 98.16%
Medchemexpress LLC Arecoline | 63-75-2 | 50 MG
Arecoline is a naturally occurring, brain-penetrant, and orally active psychoactive alkaloid. It acts as a partial agonist of both nicotinic and muscarinic acetylcholine receptors. It has been observed to induce stimulation, alertness, anxiolysis, and anti-parasitic effects, and can also induce oxidative stress.
- Naturally brain-penetrant and orally active psychoactive alkaloid.
- Partial agonist of nicotinic and muscarinic acetylcholine receptors.
- Exhibits stimulation, alertness, anxiolysis, and anti-parasitic effects.
- High purity: 99.84%.
Apexbio Technology LLC Teneligliptin hydrobromide 906093-29-6 10mM (in 1mL DMSO)
Teneligliptin hydrobromide (CAS 906093-29-6) is a potent dipeptidyl peptidase-4 (DPP-4) inhibitor exhibiting competitive inhibition of human and rat plasma DPP-4 with an IC50 of approximately 1 nM DPP-4 also known as CD26 is a cell surface protease involved in immunoregulation signal transduction and apoptosis In vitro Teneligliptin hydrobromide reduces reactive oxygen species and modulates cell cycle and apoptotic gene expression in human endothelial cells exposed to high glucose In vivo it ameliorates hepatic steatosis and metabolic disturbances in murine models partly through activation of hepatic AMPK This compound supports studies of metabolic oxidative and inflammatory pathways