Hydrochlorides
Medchemexpress LLC TG 100572 hydrochloride | 867331-64-4 | 98.8% | 512.43 g/mol | C26H27Cl2N5O2 | 1 ML
TG 100572 Hydrochloride is the hydrochloride salt of a multi-targeted kinase inhibitor that blocks selected receptor tyrosine kinases and Src family kinases. It is provided for research use in biochemical and cell-based studies and is available as a ready-to-use solution or as a solid form.
- Multi-targeted kinase inhibitor active against receptor tyrosine kinases and Src family kinases.
- Supplied as a 10 mM solution in DMSO (1 mL) for immediate use.
- Also available as a solid with a pink to red appearance.
- High purity (~98.8%) suitable for research applications.
- Store sealed, away from moisture; in solvent store at -80°C for up to 6 months.
Medchemexpress LLC Harmalol hydrochloride | 6028-07-5 | 50 MG
Harmalol hydrochloride is a beta carboline alkaloid found in medicinal plants such as Peganum harmala, and is the main metabolite of Harmaline. This compound inhibits the dioxin-mediated induction of CYP1A1 at both transcriptional and posttranslational levels, and demonstrates antioxidant and hydroxyl radical-scavenging properties. It is intended for research use only.
- Found in medicinal plants, including Peganum harmala
- Main metabolite of Harmaline
- Inhibits dioxin-mediated induction of CYP1A1
- Exhibits antioxidant properties
- Demonstrates hydroxyl radical-scavenging properties
- For research use only
- Solid appearance, light yellow to yellow color
Medchemexpress LLC Ambroxol hydrochloride (Standard) | 23828-92-4 | 99.9% | 100 MG
Ambroxol hydrochloride (Standard) is an analytical standard and an active metabolite of Bromhexine with potent expectorant effects. It acts as a glucocerebrosidase (GCase) chaperone, increasing GCase activity and inducing lung autophagy. This product is intended for research and analytical applications, including studies related to Parkinson's disease and neuronopathic Gaucher disease.
- Analytical standard for research and analytical applications.
- Active metabolite with expectorant effects.
- Increases glucocerebrosidase activity.
- Induces lung autophagy.
- Potential for Parkinson disease research.
- Potential for neuronopathic Gaucher disease research.
- Used in qualitative research experiments.
- Used in quantitative research experiments.
- Used in methodological research experiments in HPLC, GC and MS.
Medchemexpress LLC 2-(4-(4-(Aminomethyl)-1-oxo-1,2-dihydrophthalazin-6-yl)-1-methyl-1H-pyrazol-5-yl)-3-fluoro-1-naphthonitrile hydrochloride | 99.88% | 460.89 | 25 MG
MRTX9768 hydrochloride is a potent, selective, orally active, first-in-class PRMT5-MTA complex inhibitor.
- Potent, selective, orally active, first-in-class PRMT5-MTA complex inhibitor.
- Inhibits SDMA and cell proliferation in HCT116 MTAP-del cells.
- Selectively targets MTAP/CDKN2A-deleted tumors, such as glioblastoma.
- Demonstrates dose-dependent inhibition of SDMA in MTAP-del tumors in xenograft studies.
- Exhibits a favorable ADME profile with good bioavailability in mice and dogs.
Medchemexpress LLC VU 0364439 | 1246086-78-1 | C18H13Cl2N3O3S | 25 MG
VU 0364439 is a mGlu4 positive allosteric modulator (PAM) with an EC50 of 19.8 nM. It exhibits better stability in HLM (63% remaining) compared to RLM (2% remaining). It is intended for research use only.
- mGlu4 positive allosteric modulator (PAM)
- EC50 of 19.8 nM
- Better stability in HLM (63% remaining) than RLM (2% remaining)
- For research use only
![Medchemexpress LLC 1-[(4-methoxyphenyl)methyl]-5-(trifluoromethoxy)indole-2,3-dione | 1160247-92-6 | 99.9% | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000231536.png-250.jpg)
Medchemexpress LLC 1-[(4-methoxyphenyl)methyl]-5-(trifluoromethoxy)indole-2,3-dione | 1160247-92-6 | 99.9% | 10 MG
VU 0238429 is a selective positive allosteric modulator of the muscarinic acetylcholine receptor subtype M5 (mAChR5), with an EC50 of approximately 1.16 μM. It is used as a research tool to probe M5-mediated GPCR signaling and neuronal pharmacology.
- Molecular formula: C17H12F3NO4.
- Molecular weight: 351.28 g/mol.
- CAS number: 1160247-92-6.
- Purity: ~99.9% by HPLC.
- Solubility: ≥150 mg/mL in DMSO; ≥2.5 mg/mL in 10% DMSO/40% PEG300/5% Tween-80/45% saline for in vivo formulations.
- Target: muscarinic acetylcholine receptor M5 (mAChR5).
- EC50: ~1.16 μM at M5; >30 μM at M1 and M3 indicating selectivity.
- Storage: powder -20°C (long term), 4°C (short term); solutions -80°C (up to 6 months).
- Quantity: supplied as a 10 mg solid.
Medchemexpress LLC VU 0240551 | 893990-34-6 | 99.70% | 342.44 | 10 MM * 1 ML
VU 0240551 is a potent inhibitor of the neuronal K-Cl cotransporter KCC2, with an IC50 of 560 nM, and demonstrates selectivity against NKCC1. It also inhibits hERG and L-type Ca2+ channels. This compound attenuates GABA-induced hyperpolarization of P cells, leading to a positive shift in the P cell GABA reversal potential and enhancing P cell synaptic transmission.
- Potent neuronal K-Cl cotransporter KCC2 inhibitor (IC50=560 nM)
- Selective versus NKCC1
- Inhibits hERG and L-type Ca2+ channels
- Attenuates GABA-induced hyperpolarization of P cells
- Produces a positive shift in the P cell GABA reversal potential
- Enhances P cell synaptic transmission
- For research use only
TARGETMOL CHEMICALS INC VU 0285683 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. VU 0285683 is a specific negative allosteric modulator of mGluR5 with a high affinity for the MPEP binding site. VU 0285683 shows anxiolytic-like activity. purity: 99%
Medchemexpress LLC Buformin hydrochloride | 1190-53-0 | 99.78% | 100 MG
Buformin hydrochloride is a potent AMPK activator and an orally active biguanide antidiabetic agent. It decreases hepatic gluconeogenesis and lowers blood glucose production in vivo. It also exhibits anti-cancer activities and is used in cancer studies.
- Potent AMPK activator
- Orally active biguanide antidiabetic agent
- Decreases hepatic gluconeogenesis
- Lowers blood glucose production in vivo
- Exhibits anti-cancer activities
- Used in cancer studies including cervical cancer and breast cancer
Medchemexpress LLC PIM-447 dihydrochloride | 1820565-69-2 | 99.8% | 513.38 | 1 ML
PIM447 dihydrochloride (LGH447 dihydrochloride) is a potent, orally available, and selective pan-PIM kinase inhibitor, with K¡ values of 6, 18, and 9 pM for PIM1, PIM2, and PIM3, respectively. PIM447 dihydrochloride displays dual antimyeloma and bone-protective effects, and induces apoptosis.
- Potent, orally available, and selective pan-PIM kinase inhibitor.
- K¡ values of 6, 18, and 9 pM for PIM1, PIM2, and PIM3, respectively.
- Displays dual antimyeloma and bone-protective effects.
- Induces apoptosis.
Medchemexpress LLC MRTX9768 hydrochloride | 2629314-68-5 | 99.9% | 460.89 | 100 MG
MRTX9768 hydrochloride is a potent, selective, orally active, first-in-class PRMT5-MTA complex inhibitor. It inhibits SDMA and cell proliferation in HCT116 MTAP-del cells, showing marked selectivity over HCT116 MTAP-WT cells. This compound leads to sustained SDMA inhibition and demonstrates dose-dependent inhibition in MTAP-del tumors in vivo. It selectively targets MTAP/CDKN2A-deleted tumors, such as glioblastoma, and exhibits a favorable ADME profile.
- Potent and selective PRMT5-MTA complex inhibitor
- Orally active
- Targets MTAP/CDKN2A-deleted tumors
- Exhibits favorable ADME profile
- Leads to sustained SDMA inhibition
- Inhibits cell proliferation in HCT116 MTAP-del cells
Medchemexpress LLC YNT-185 dihydrochloride | 1804978-82-2 | 99.8% | 688.66 | 25 MG
YNT-185 dihydrochloride is a nonpeptide, selective orexin type-2 receptor (OX2R) agonist. It demonstrates high selectivity with EC50s of 0.028 μM for OX2R and 2.75 μM for OX1R. This compound has been shown to ameliorate narcolepsy-cataplexy symptoms in mouse models, increasing wakefulness and decreasing NREM sleep time.
- Selective orexin type-2 receptor (OX2R) agonist
- Nonpeptide compound
- EC50 of 0.028 μM for OX2R
- Ameliorates narcolepsy-cataplexy symptoms in mouse models
- Increases wakefulness
- Decreases NREM sleep time
Medchemexpress LLC PIM-447 (dihydrochloride) | 1820565-69-2 | 99.8% | 513.38 | 50 MG
PIM-447 (dihydrochloride) | 1820565-69-2 | 99.8% | 513.38 | 50 MG
eMolecules 89990-54-5 | pyrazolidine dihydrochloride | Pharmablock | MFCD16620353 | 145.030 | C3H10Cl2N2 | 97.000 | Cl.Cl.C1CNNC1 | 1g | 717427045
pyrazolidine dihydrochloride | Pharmablock | 89990-54-5 | MFCD16620353 | 145.030 | C3H10Cl2N2 | 97.000 | Cl.Cl.C1CNNC1 | 1g | 717427045
Medchemexpress LLC Nilotinib hydrochloride dihydrate | 00-00-0 | MFCD09833716 | 99.9% | 602.01 g/mol | C28H27ClF3N7O3 | 100 MG
Nilotinib hydrochloride dihydrate is the hydrochloride salt, dihydrate form of nilotinib, supplied as a white to off-white solid for research use. It functions as a Bcr-Abl tyrosine kinase inhibitor and is intended for biochemical and cell-based studies of Bcr-Abl signaling and leukemia models, provided in laboratory-scale quantities for in vitro and preclinical experiments.
- High purity suitable for research-grade assays.
- Hydrochloride dihydrate salt form for improved handling and reproducibility.
- Soluble in DMSO at high concentrations (≈100 mg/mL) with ultrasonic assistance.
- Stable when stored sealed at 4°C; long-term storage in solvent at -80°C.
- White to off-white powder form for easy weighing and dissolution.