Hydrochlorides
Medchemexpress LLC VU 0357121 | 433967-28-3 | C17H17F2NO2 | 100 MG
VU 0357121 is a positive and highly selective mGlu5R allosteric modulator (PAM) with an EC50 of 33 nM. It is inactive or very weakly antagonizing at other mGlu receptor subtypes. It enhances glutamate sensitivity of mGlu5, likely due to an interaction at a site on the receptor distinct from the MPEP binding site, and does not possess mGlu5 NAM activity. It is for research use only.
- Enhances glutamate sensitivity of mGlu5
- Does not bind at the MPEP allosteric site of mGlu5
- A809V/rmGlu5 mutation inhibited the ability to shift the glutamate concentration response curve
- Response is not altered by the F585I/rmGlu5 mutation
Medchemexpress LLC UAMC-3203 hydrochloride | 2271358-65-5 | 98.1% | 508.12 | 100 MG
UAMC-3203 hydrochloride is a potent and selective ferroptosis inhibitor with an IC50 of 12 nM. It is for research use only and not sold to patients.
- No toxicity observed in mice after repeated injections.
- Available in solid and solution forms.
- Ships at room temperature in continental US.
- Store at 4°C, sealed, away from moisture and light.
- When in solvent, store at -80°C for 6 months or -20°C for 1 month, sealed, away from moisture and light.
Medchemexpress LLC VU0364770 hydrochloride | 1414842-70-8 | 99.7% | 269.13 g/mol | C12H10Cl2N2O | 1 ML
VU0364770 hydrochloride is a selective and potent positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu4), supplied as a ready-to-use 10 mM solution in DMSO for laboratory research. The compound has reported physicochemical identifiers and storage recommendations for reliable experimental use.
Medchemexpress LLC VU 0357121 | 433967-28-3 | C17H17F2NO2 | 1 ML
VU 0357121 is a positive and highly selective mGlu5R allosteric modulator (PAM) with an EC50 of 33 nM. It is inactive or very weakly antagonizing at other mGlu receptor subtypes.
- Positive and highly selective mGlu5R allosteric modulator (PAM)
- EC50 of 33 nM for mGlu5 receptor
- Inactive or very weakly antagonizing at other mGlu receptor subtypes
- Enhances glutamate sensitivity of mGlu5
- Does not bind at the MPEP allosteric site of mGlu5
- For research use only
Medchemexpress LLC RS-102221 hydrochloride | 187397-18-8 | 98.0% | 649.08 g/mol | C27H32ClF3N4O7S | 50 MG
RS-102221 hydrochloride is a selective 5-HT2C receptor antagonist used in preclinical research to probe serotonin 5-HT2C-mediated signaling. It exhibits high affinity (Ki ≈ 10 nM) and strong selectivity versus related receptor subtypes and is supplied as a white to off-white solid for laboratory use.
- Selective 5-HT2C receptor antagonist with high affinity.
- Approximately 100-fold selectivity over 5-HT2A and 5-HT2B receptors.
- Supplied as a white to off-white solid suitable for research.
- Available in multiple small-scale sizes for laboratory experiments.
- Stable when stored under recommended conditions for powder and solutions.
Apexbio Technology LLC Duloxetine HCl 136434-34-9 10mM (in 1mL DMSO)
Duloxetine hydrochloride (CAS 136434-34-9) is a small molecule compound classified as a selective inhibitor of serotonin and norepinephrine reuptake By blocking the reabsorption of these neurotransmitters at the synaptic cleft duloxetine modulates serotonergic and noradrenergic signaling within the central nervous system This pharmacological action has rendered it a valuable tool in research models investigating neurochemical pathways involved in mood regulation pain perception and stress response Duloxetine HCl is commonly utilized in studies of depression anxiety and chronic pain to elucidate monoaminergic mechanisms and to evaluate therapeutic strategies targeting neurotransmitter reuptake
Medchemexpress LLC RS-127445 hydrochloride | 199864-86-3 | C17H17ClFN3 | 100 MG
RS-127445 hydrochloride is a selective, high-affinity, and orally bioavailable 5-HT2B receptor antagonist. It exhibits 1000-fold selectivity for the 5-HT2B receptor compared to numerous other receptor and ion channel binding sites, making it a valuable tool for research into serotonin receptor activity and related biological pathways.
- Selective and high-affinity 5-HT2B receptor antagonist
- Orally bioavailable
- Exhibits 1000-fold selectivity over many other receptors
- Potently blocks 5-HT evoked increases in intracellular calcium concentrations
- Reduces faecal output in rats dose-dependently
Medchemexpress LLC Cyclopentanecarboxylic acid, 1-(4-nitrophenyl)-, 2-(diethylamino)ethyl ester, hydrochloride | 98636-73-8 | MFCD00673872 | 99.6% | 370.87 g/mol | C18H27ClN2O4 | 25 MG
Nitrocaramiphen hydrochloride is a selective M1 muscarinic receptor antagonist supplied as the hydrochloride salt for research use. It inhibits muscarine-induced hyperpolarization in muscle fibers and is provided as a white to off-white solid suitable for biochemical and pharmacological studies.
- Selective M1 receptor antagonist (Ki: 5.5 nM).
- High purity: 99.6% (manufacturer COA).
- White to off-white solid, molecular formula C18H27ClN2O4.
- Molecular weight 370.87 g/mol.
- Available in small milligram quantities for research use.
- Store sealed away from moisture; in solvent: -80°C (6 months), -20°C (1 month).
Medchemexpress LLC EG01377 dihydrochloride | 2749438-61-5 | 99.0% | 659.60 | 1 MG
EG01377 dihydrochloride | 2749438-61-5 | 99.0% | 659.60 | 1 MG
Medchemexpress LLC CP 93129 dihydrochloride | 879089-64-2 | 99.0% | 288.17 g·mol⁻1 | C12H15Cl2N3O | 1 MG
CP 93129 dihydrochloride is a selective 5-HT1B receptor agonist supplied for research use. It is used in pharmacology and neuroscience studies, including investigations related to Parkinson's disease, and is provided as a high-purity solid suitable for analytical, in vitro, and in vivo applications.
- Selective 5-HT1B receptor agonist suitable for receptor pharmacology studies.
- High purity (99.0%) for consistent experimental results.
- Molecular weight 288.17 g·mol⁻1 and formula C12H15Cl2N3O for precise calculations.
- Off-white to light yellow solid for convenient handling and storage.
- Recommended storage at 4°C, sealed and protected from moisture and light.
- Available in small, accurately weighed milligram quantities for dosing and assays.
Medchemexpress LLC Piperoxan hydrochloride | 135-87-5 | 99.7% | 269.77 g·mol^-1 | C14H20ClNO2 | 100 MG
Piperoxan hydrochloride is a research chemical described as an α2 adrenoceptor antagonist and a first-generation antihistamine, provided for laboratory pharmacology and biochemical studies. Consult the product datasheet and safety data sheet for handling, storage, and purity specifications.
- High reported purity (about 99.7%).
- Available as a solid and as a 10 mM solution in DMSO.
- Suitable for pharmacology and biochemical research applications.
- CAS number provided for unambiguous identification.
- Manufacturer datasheet and SDS available for safety and handling.
Medchemexpress LLC Cgp 12177 hydrochloride | 64208-32-8 | 99.7% | 315.80 g·mol⁻¹ | C14H22ClN3O3 | 5 MG
CGP 12177 hydrochloride is a research-grade β-adrenergic receptor ligand supplied as the hydrochloride salt. It is used in pharmacological studies of β-adrenoceptors and in cardiovascular and metabolic disease research.
- High reported purity (~99.7%).
- Molecular formula C14H22ClN3O3 and molecular weight 315.80 g·mol⁻¹.
- Acts as a β3-adrenergic receptor agonist and β1/β2 antagonist in receptor assays.
- Available in small milligram pack sizes suitable for laboratory studies.
- Provided with supporting datasheet and specifications for research use.
Medchemexpress LLC Piperoxan hydrochloride | 135-87-5 | MFCD00079224 | 99.7% | 269.77 g/mol | C14H20ClNO2 | 50 MG
Piperoxan hydrochloride is a small-molecule research reagent that functions as an α2 adrenoceptor antagonist and an early-generation antihistamine. Supplied as the hydrochloride salt in high purity, it is used in receptor pharmacology, GPCR studies, and biochemical assays, and is commonly provided as small solid quantities or prepared DMSO stock solutions.
- α2 adrenoceptor antagonist activity suitable for receptor pharmacology studies.
- First-generation antihistamine properties for comparative pharmacology.
- High purity (manufacturer-reported ~99.7%) appropriate for biochemical assays.
- Available as small solid quantities and as prepared DMSO solutions for convenience.
- Molecular formula C14H20ClNO2 and molecular weight 269.77 g/mol.
- Safety and quality documents available, including SDS and COA.
Medchemexpress LLC ZM323881 hydrochloride | 193000-39-4 | C22H19ClFN3O2 | 1 ML
ZM323881 hydrochloride is a potent and selective inhibitor of Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) with an IC50 of less than 2 nM. This anilinoquinazoline specifically targets VEGFR2 tyrosine kinase activity, demonstrating excellent selectivity over other receptor tyrosine kinases.
- Potent and selective VEGFR2 inhibitor
- High purity (99.63%)
- Specifically targets VEGFR2 tyrosine kinase activity
- Exhibits excellent selectivity over other receptor tyrosine kinases
- Inhibits VEGF-A-induced endothelial cell proliferation
- Inhibits VEGFR2 tyrosine phosphorylation
- Molecular Weight: 411.86
- Formula: C22H19ClFN3O2
- Appearance: Solid, light yellow to yellow