Hydrochlorides
Medchemexpress LLC PIM-447 (dihydrochloride) | 1820565-69-2 | 99.8% | 513.38 | 1 MG
PIM-447 dihydrochloride (LGH447 dihydrochloride) is a potent, orally available, and selective pan-PIM kinase inhibitor. With Ki values of 6, 18, and 9 pM for PIM1, PIM2, and PIM3, it displays dual antimyeloma and bone-protective effects, and induces apoptosis. This compound is for research use only.
- Potent, orally available, and selective pan-PIM kinase inhibitor
- Inhibits PIM1, PIM2, and PIM3 with picomolar affinity
- Exhibits dual antimyeloma and bone-protective effects
- Induces apoptosis in multiple myeloma cells
- Increases annexin-V levels and promotes caspase cleavage
- Controls tumor progression in mouse models
Medchemexpress LLC Azvudine hydrochloride | 1333126-31-0 | 99.2% | 322.68 | 1 ML
Azvudine hydrochloride | 1333126-31-0 | 99.2% | 322.68 | 1 ML
Medchemexpress LLC Erlotinib hydrochloride | 183319-69-9 | 99.9% | 100MG
Erlotinib hydrochloride | 183319-69-9 | 99.9% | 100MG
Medchemexpress LLC Etazolate hydrochloride | 35838-58-5 | MFCD00209848 | 98.0% | 325.79 | C14H20ClN5O2 | 5 MG
Etazolate hydrochloride is a pyrazolopyridine research compound that functions as a selective phosphodiesterase-4 (PDE4) inhibitor, a GABAA receptor regulator, and an α-secretase activator. It is used in neuropharmacology and inflammation studies to probe cAMP signaling, amyloid precursor protein processing, and behavioral pharmacology.
Medchemexpress LLC Cgp 12177 hydrochloride | 64208-32-8 | MFCD00069230 | 99.7% | 315.80 | C14H22ClN3O3 | 10 MG
CGP 12177 hydrochloride is a research-grade β-adrenergic receptor ligand commonly used in cardiovascular and metabolic disease studies to probe adrenergic receptor function. It is provided as the hydrochloride salt with high reported purity for laboratory research.
- Acts as a β1/β2 antagonist and partial β3 agonist.
- Suitable for in vitro and in vivo pharmacology studies.
- High reported purity for consistent experimental results.
- Available in small milligram packages for precise dosing in experiments.
Medchemexpress LLC Aq-13 dihydrochloride | 169815-40-1 | MFCD01938526 | 98.1% | 364.74 | C16H24Cl3N3 | 100 MG
AQ-13 dihydrochloride is an aminoquinoline antimalarial compound active against drug-resistant strains of Plasmodium falciparum, provided for research use. It is supplied as a light yellow solid and in solution formats, with molecular formula C16H24Cl3N3 and molecular weight 364.74.
- Active against drug-resistant Plasmodium falciparum.
- High purity (98.08%) appropriate for research applications.
- Available as a light yellow solid and in solution formats.
- Soluble in DMSO and water; may require ultrasonic agitation.
- Stable when stored sealed away from moisture; in solvent, -80°C (6 months) or -20°C (1 month).
- Molecular formula C16H24Cl3N3; molecular weight 364.74.
Medchemexpress LLC Ly2365109 hydrochloride | 1779796-27-8 | MFCD12828768 | 98.7% | 421.91 | C22H28ClNO5 | 1 ML
LY2365109 hydrochloride is a potent, selective glycine transporter 1 (GlyT1) inhibitor intended for laboratory research use. It inhibits glycine uptake in cells over-expressing hGlyT1a with an IC50 of 15.8 nM and is supplied with high purity for biochemical and pharmacological assays.
- Potent GlyT1 inhibition (IC50 15.8 nM).
- High purity suitable for research (≈98.7%).
- Available as solid or 10 mM solution in DMSO.
- White to off-white solid appearance.
- Suitable for in vitro pharmacology and uptake assays.
Medchemexpress LLC d,l-SKF89976A hydrochloride | 85375-15-1 | 98.7% | 371.90 | C22H26ClNO2 | 100 MG
SKF89976A hydrochloride is a research reagent that selectively inhibits the GABA transporter GAT-1 and is used in preclinical studies to probe GABA uptake and transporter pharmacology. Reported data in CHO cells show submicromolar potency at GAT-1 and substantially weaker activity at other GAT subtypes.
Medchemexpress LLC Terbinafine hydrochloride | 78628-80-5 | 99.9% | 327.89 | 1 ML
Terbinafine hydrochloride (TDT 067 hydrochloride) is an orally active and potent antifungal agent. It acts as a non-competitive inhibitor of squalene epoxidase from Candida, with a Ki of 30 nM. This compound also exhibits antibacterial activity against certain Gram-positive and Gram-negative bacteria. Furthermore, it is a click chemistry reagent, containing an Alkyne group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules possessing Azide groups.
- Primarily shows fungicidal action against most fungal pathogens, including dermatophytes, dimorphic, and filamentous fungi.
- Specifically inhibits fungal ergosterol biosynthesis by blocking squalene epoxidation.
- Leads to rapid accumulation of squalene and a deficiency of ergosterol in treated fungal cells.
- Effective in experimental dermatophytoses following oral administration and topical application.
Medchemexpress LLC Buformin hydrochloride | 1190-53-0 | 99.8% | 1 ML
Buformin hydrochloride is a potent AMPK activator and an orally active biguanide antidiabetic agent. It decreases hepatic gluconeogenesis and lowers blood glucose production in vivo. It also exhibits anti-cancer activities and is used in cancer studies (e.g., cervical cancer and breast cancer).
- Potent AMPK activator
- Orally active biguanide antidiabetic agent
- Decreases hepatic gluconeogenesis
- Lowers blood glucose production in vivo
- Has anti-cancer activities, applied in cancer studies (e.g., cervical cancer and breast cancer)
Medchemexpress LLC Ambroxol hydrochloride | 23828-92-4 | 99.9% | 50 MG
Ambroxol hydrochloride | 23828-92-4 | 99.9% | 50 MG
Medchemexpress LLC Ambroxol (hydrochloride) | 23828-92-4 | 99.96% | 500 MG
Ambroxol hydrochloride, an active metabolite of Bromhexine, possesses potent expectorant effects. It acts as a glucocerebrosidase (GCase) chaperone, increasing glucocerebrosidase activity. This compound also induces lung autophagy and shows potential for research in Parkinson's disease and neuronopathic Gaucher disease.
- Potent expectorant effects
- Increases glucocerebrosidase activity
- Induces lung autophagy
- Potential for research in Parkinson's disease
- Potential for research in neuronopathic Gaucher disease
Medchemexpress LLC Azaphen dihydrochloride monohydrate | 63302-99-8 | 99.9% | C16H23Cl2N5O2 | 1 ML
Azaphen dihydrochloride monohydrate, also known as Pipofezine, is a potent inhibitor of serotonin reuptake. This tricyclic antidepressant (TCA) is approved in Russia for the treatment of depression.
- Potent inhibitor of serotonin reuptake
- Tricyclic antidepressant for depression treatment
- Available as a 10 mM solution in water
- High purity for reliable research applications
eMolecules 1080640-91-0 | 8-(TRIFLUOROMETHYL)QUINOLIN-6-AMINE | AstaTech | MFCD11052592 | 212.175 | C10H7F3N2 | 95.000 | Nc1cc(c2ncccc2c1)C(F)(F)F | 1g | 410713139
8-(TRIFLUOROMETHYL)QUINOLIN-6-AMINE | AstaTech | 1080640-91-0 | MFCD11052592 | 212.175 | C10H7F3N2 | 95.000 | Nc1cc(c2ncccc2c1)C(F)(F)F | 1g | 410713139
Medchemexpress LLC PXS-4787 hydrochloride | 2409964-40-3 | C10H13ClFNO2S | 10 MM * 1 ML
PXS-4787 hydrochloride is a specific and effective pan-LOX (lysyl oxidase) inhibitor that abolishes lysyl oxidase activity. It inhibits LOX with IC50s of 2 μM (Bovine LOX), 3.2 μM (rh LOXL1), 0.6 μM (rh LOXL2), 1.4 μM (rh LOXL3), and 0.2 μM (rh LOXL4). This compound also reduces the deposition and crosslinking of collagen I secreted by human fibroblasts. It is for research use only and not sold to patients.
- Specific and effective pan-LOX inhibitor
- Abolishes lysyl oxidase activity
- Inhibits LOX with IC50s of 2 μM (Bovine LOX), 3.2 μM (rh LOXL1), 0.6 μM (rh LOXL2), 1.4 μM (rh LOXL3), and 0.2 μM (rh LOXL4)
- Reduces deposition and crosslinking of collagen I secreted by human fibroblasts
- For research use only