Hydrochlorides
Medchemexpress LLC OPC-14523 hydrochlor 10mM 1mL | 145969-31-9 | 450.40 g/mol | C23H29Cl2N3O2 | 1 ML
OPC-14523 hydrochloride is a sigma and 5-HT1A receptor agonist supplied as a hydrochloride salt for research use. It is available as a lyophilized solid and as a ready-to-use 10 mM solution in DMSO, with documented solubility and storage recommendations for in vitro and in vivo studies.
- Hydrochloride salt form for improved stability and handling.
- High purity (99.95%) suitable for pharmacology studies.
- Chemical formula C23H29Cl2N3O2; molecular weight 450.40 g/mol.
- Available as solid in multiple mg sizes and as a 10 mM, 1 mL solution in DMSO.
- Soluble in DMSO (~83.3 mg/mL) and moderately soluble in water with warming.
- Recommended storage: sealed, away from moisture; in solvent: -20°C short term, -80°C long term.
Medchemexpress LLC Mafenide hydrochloride | 138-37-4 | MFCD00013005 | 99.97% | 50 MG
Mafenide hydrochloride is an effective sulfonamide-type antimicrobial agent used for burn wounds. It shows activity against both Gram-positive and Gram-negative organisms, including Pseudomonas aeruginosa, via inhibition of nucleotide synthesis.
- Effective sulfonamide-type antimicrobial agent
- Used for burn wounds
- Active against Gram-positive organisms
- Active against Gram-negative organisms
- Effective against Pseudomonas aeruginosa
- Inhibits nucleotide synthesis
- Regulatory Status: RUO
- Ships at room temperature
- Store at 4°C, sealed, and away from moisture
Medchemexpress LLC Y-33075 dihydrochloride | 173897-44-4 | 98.81% | 353.25 | 25 MG
Y-33075 dihydrochloride is a selective ROCK inhibitor with an IC50 of 3.6 nM.
- Selective ROCK inhibitor with an IC50 of 3.6 nM.
- Inhibits PKC (IC50 of 420 nM) and CaMKII (IC50 of 810 nM) more potently than Y-27632.
- Extends neurites in retinal ganglion cells (RGCs).
- Inhibits the contraction of rabbit ciliary artery segments evoked by histamine in Ca2+-free solutions.
- Significantly lowers intraocular pressure (IOP) in rabbits and monkeys after topical administration.
- Increases regenerating axons of retinal ganglion cells (RGCs) in rats.
eMolecules 115445-31-3 | 3-(Trifluoroacetamido)pyrrolidine hydrochloride | Oakwood Chemical | MFCD01090944 | 218.600 | C6H10ClF3N2O | 98.000 | Cl.FC(F)(F)C(=O)NC1CCNC1 | 1g | 537671980
3-(Trifluoroacetamido)pyrrolidine hydrochloride | Oakwood Chemical | 115445-31-3 | MFCD01090944 | 218.600 | C6H10ClF3N2O | 98.000 | Cl.FC(F)(F)C(=O)NC1CCNC1 | 1g | 537671980
Medchemexpress LLC Vu 0238429 | 1160247-92-6 | 99.9% | 1 ML
Vu 0238429 is a positive allosteric modulator of the muscarinic acetylcholine receptor subtype 5 (mAChR5 or M5) with an EC50 of 1.16 μM. It is supplied as a 10 mM solution in DMSO or as a solid and is intended for research use.
- Positive allosteric modulation of M5 receptor (EC50 1.16 μM).
- Greater than 30-fold selectivity over M1 and M3 receptors.
- No potentiator activity observed at M2 or M4 receptors.
- Available as 10 mM solution in DMSO and multiple solid sizes.
- High reported purity (≈99.9%).
Medchemexpress LLC Tirofiban hydrochloride monohydrate | 150915-40-5 | 99.9% | 495.07 | 500 MG
Tirofiban hydrochloride monohydrate is a selective and reversible platelet integrin receptor (Gp IIb/IIIa) antagonist. It inhibits fibrinogen binding to this receptor and demonstrates antithrombotic activity. This compound also induces proliferation and migration on endothelial cells by stimulating VEGF production, and can significantly reduce myocardial no-reflow and ischemia-reperfusion injury by improving myocardial microvascular structural and endothelial dysfunction in ischemic areas.
- Selective and reversible platelet integrin receptor (Gp IIb/IIIa) antagonist
- Inhibits fibrinogen binding
- Antithrombotic activity
- Induces proliferation and migration on endothelial cells
- Stimulates VEGF production
- Reduces myocardial no-reflow and ischemia-reperfusion injury
- Alleviates myocardial microvascular dysfunction
Medchemexpress LLC PB28 dihydrochloride | 172907-03-8 | CB4497464 | 99.6% | 443.49 | 25 MG
PB28 dihydrochloride is a cyclohexylpiperazine derivative, functioning as a high-affinity sigma 2 (σ2) receptor agonist with a Ki of 0.68 nM and a σ1 antagonist with a Ki of 0.38 nM. It demonstrates lower affinity for other receptors. This compound inhibits electrically evoked twitch in guinea pig bladder and ileum with EC50 values of 2.62 μM and 3.96 μM, respectively. It can modulate SARS-CoV-2-human protein-protein interaction, induces caspase-independent apoptosis, and exhibits antitumor activity.
- Accumulates in the G0-G1 phase for MCF7 and MCF7 ADR cells.
- Inhibits cell growth in MCF7 and MCF7 ADR cells.
- Induces apoptosis via a caspase-independent pathway.
- Reduces P-gp expression in MCF7 and MCF7 ADR cells.
- Displays antiproliferative and cytotoxic effects in C6 rat glioma and SK-N-SH human neuroblastoma cell lines.
- Inhibits tumor growth in Panc02 tumor burden mice.
Medchemexpress LLC Duloxetine | 116539-59-4 | 99.9% | 50 MG
Duloxetine is a serotonin-norepinephrine reuptake inhibitor with a Ki of 4.6 nM. It is used for the treatment of major depressive disorder and generalized anxiety disorder (GAD). For research use only; not sold to patients. Duloxetine inhibits the reuptake of serotonin and norepinephrine in the central nervous system. It is also considered a less potent inhibitor of dopamine reuptake. Duloxetine has no significant affinity for dopaminergic, adrenergic, cholinergic, histaminergic, opioid, glutamate, and GABA receptors, making it a selective reuptake inhibitor at the 5-HT and NA transporters.
- Inhibits serotonin and norepinephrine reuptake
- Treats major depressive disorder and generalized anxiety disorder
- Acts as a less potent inhibitor of dopamine reuptake
- Functions as a selective reuptake inhibitor at 5-HT and NA transporters
- For research use only
eMolecules 121010-86-4 | (R)-3-Aminopyrrolidin-2-one | MFCD11501145 | 1g
Ambeed | 3-Bromo-2-hydroxybenzonitrile | 1g | 552745984 | A597142 | 13073-28-4 | MFCD11042854 | 198.019 | C7H4BrNO
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Medchemexpress LLC DAPI dihydrochloride | 28718-90-3 | 99.9% | 25 MG
DAPI dihydrochloride | 28718-90-3 | 99.9% | 25 MG
Medchemexpress LLC Ecopipam hydrochloride | 190133-94-9 | 99.5% | C19H21Cl2NO | 10MG
Ecopipam hydrochloride is the hydrochloride salt of ecopipam, a selective and orally active dopamine D1/D5 receptor antagonist used in research on dopaminergic signaling. It is supplied as a white to off-white solid with high reported purity and is intended for laboratory research applications.
- Selective antagonist of dopamine D1/D5 receptors.
- High purity suitable for research applications.
- White to off-white solid, stable under recommended storage.
- Molecular formula C19H21Cl2NO; molecular weight 350.28.
- Packaged in small research quantities for laboratory studies.
Medchemexpress LLC SB-224289 (hydrochloride) | 180084-26-8 | MFCD03788209 | 99.0% | 557.08 | C32H33ClN4O3 | 50 MG
SB-224289 hydrochloride is a research-grade hydrochloride salt that acts as a selective 5-HT1B (serotonin 1B) receptor antagonist, used in preclinical studies to probe serotonergic signaling and related behavioral effects such as anxiolysis. The compound is supplied with high stated purity and should be stored under low-temperature, moisture-free conditions.
- Selective 5-HT1B receptor antagonist for targeted pharmacological studies.
- Useful for probing serotonergic signaling and anxiolytic-related behavior in preclinical research.
- High stated purity (99.0%).
- Supplied as the hydrochloride salt in solid form for stability.
- Recommended storage at low temperature, protected from moisture.
- Available in small research quantities suitable for laboratory experiments.
Medchemexpress LLC Dapoxetine hydrochloride | 129938-20-1 | 100.0% | 341.87 | C21H24ClNO | 10 MG
Dapoxetine hydrochloride is the hydrochloride salt of dapoxetine, an orally active selective serotonin reuptake inhibitor (SSRI) used in research on premature ejaculation and serotonin transporter pharmacology. It potently inhibits serotonin uptake and has weaker activity at norepinephrine and dopamine transporters. Supplied as a white to off-white solid with high analytical purity and defined storage recommendations.
- Serotonin transporter (SERT) inhibitor (5-HT uptake IC50 ≈ 1.12 nM)
- Shows measurable norepinephrine and dopamine activity
- High purity suitable for analytical and research use
- White to off-white solid, stable when stored sealed away from moisture
- Available in small mass quantities for laboratory studies
Medchemexpress LLC MRT68921 dihydrochloride | 2080306-21-2 | 99.7% | 507.50 | C25H36Cl2N6O | 50 MG
MRT68921 dihydrochloride is a potent small-molecule inhibitor of ULK1/ULK2 and NUAK1 used in biochemical and cellular research to probe autophagy and kinase signaling. Supplied as a high-purity solid for laboratory research applications only.
- Potent NUAK1/ULK1 dual inhibitor.
- Suitable for biochemical and cell-based assays.
- High purity: 99.7%.
- Molecular weight: 507.50.
- Storage: solid at 4°C; solutions -80°C for long-term.
- Appearance: white to off-white solid.
Medchemexpress LLC TAS-103 dihydrochloride | 174634-09-4 | MFCD00943251 | 98.5% | 406.31 g/mol | C20H21Cl2N3O2 | 5 MG
TAS-103 dihydrochloride is a small-molecule dual inhibitor of DNA topoisomerase I and II used in cancer research. Supplied as the dihydrochloride salt with reported high purity, it is provided as a powder suitable for biochemical and cellular assays and laboratory research.