Hydrochlorides
Medchemexpress LLC GW405833 hydrochloride | 1202865-22-2 | 99.6% | 483.82 | 10 MG
GW405833 hydrochloride | 1202865-22-2 | 99.6% | 483.82 | 10 MG
Medchemexpress LLC MRT68921 dihydrochloride | 2080306-21-2 | 99.7% | 507.50 | C25H36Cl2N6O | 10 MG
MRT68921 dihydrochloride is a research reagent and potent small-molecule inhibitor of NUAK1 and ULK1 used in cellular studies of autophagy, oxidative stress, and apoptosis. It demonstrates low-nanomolar inhibitory activity against ULK kinases and is used to probe autophagy-related pathways and anti-proliferative responses in cancer research.
- Potent dual NUAK1/ULK1 inhibitory activity with low-nanomolar IC50 values.
- Demonstrated ULK2 inhibition at 1.1 nM and ULK1 inhibition at 2.9 nM.
- Used for in vitro studies of autophagy modulation, ROS production, and apoptosis.
- High reported purity suitable for analytical and biological assays.
- Provided as a solid with molecular weight 507.50 and formula C25H36Cl2N6O.
Medchemexpress LLC KB-0742 dihydrochloride | 2416874-75-2 | 98.8% | 360.33 | 10 MG
KB-0742 dihydrochloride is a potent, selective, and orally active CDK9 inhibitor with an IC50 of 6 nM for CDK9/cyclin T1. It exhibits significant selectivity over other CDK kinases and demonstrates potent anti-tumor activity.
- Potent, selective, and orally active CDK9 inhibitor
- Shows over 50-fold selectivity for CDK9/cyclin T1
- Exhibits potent anti-tumor activity
- Significantly reduces downstream phosphorylation of RNA Pol II
- Reduces global androgen receptor protein levels
- Shows cytostatic effects in prostate cancer and leukemia cell lines
- Well tolerated and reduces tumor burden in xenograft models
- Soluble in H2O and DMSO
Medchemexpress LLC GR 55562 dihydrochloride | 159533-25-2 | 99.0% | 448.39 | C23H27Cl2N3O2 | 10 MG
GR 55562 dihydrochloride is a research-grade small molecule that acts as a selective 5-HT1B (serotonin) receptor antagonist for preclinical and in vitro studies probing 5-HT1B-mediated signaling and neurological disease mechanisms.
- Selective 5-HT1B receptor antagonist.
- High purity (99.0%).
- Solid form suitable for analytical and biological assays.
- Store under nitrogen, away from moisture; solvent storage -80°C (6 months) or -20°C (1 month).
- Available in 5 mg and 10 mg pack sizes.
Medchemexpress LLC 2-iminothiolane hydrochloride | 4781-83-3 | MFCD00039013 | 99.9% | 137.63 | C4H8ClNS | 10 MG
2-Iminothiolane hydrochloride is a thiolating reagent used to introduce sulfhydryl (-SH) groups into primary amines of proteins, peptides, and oligosaccharides. It reacts under near-physiological conditions to expose free thiols for subsequent conjugation, crosslinking, or labeling in bioconjugation workflows.
- Reacts with primary amines at pH 7-10 to generate free thiols.
- Forms an amidine linkage that tethers the thiol to the substrate.
- Enables protein and peptide modification for bioconjugation.
- Suitable for glycan labeling and oligosaccharide modification.
- High purity for reproducible experimental results (>99.9%).
- Solid, white to off-white material that is easy to handle and weigh.
- Available in small research-scale pack sizes for laboratory use.
Medchemexpress LLC PIM-447 dihydrochloride | 1820565-69-2 | MFCD30489747 | 99.3% | 513.38 | C24H25Cl2F3N4O | 10 MG
PIM-447 dihydrochloride is the dihydrochloride salt of a potent, orally available pan-PIM kinase inhibitor used in preclinical research. It modulates apoptosis and JAK/STAT signaling and has been investigated for antimyeloma and bone-protective effects. This reagent is supplied for laboratory research use only.
- Potent pan-PIM kinase inhibition with low picomolar Ki values.
- Demonstrated antimyeloma and bone-protective activity in preclinical studies.
- High solubility in water and DMSO (H2O: 50 mg/mL; DMSO: ≥46.7 mg/mL).
- High purity (≈99.3%).
- Provided as a 10 mg solid suitable for preparing concentrated stock solutions.
- Stability supported by recommended storage conditions in solvent (-80°C 1 year; -20°C 6 months).
- Intended for research use only; not for human or veterinary use.
Medchemexpress LLC Lp-533401 hydrochloride | 1040526-12-2 | MFCD18803629 | 95.2% | 562.94 | C27H23ClF4N4O3 | 10 MG
LP-533401 hydrochloride is a small-molecule inhibitor of tryptophan hydroxylase 1 (TPH1) used in research to reduce peripheral serotonin production and to study bone and gut serotonin biology. It exhibits potent in vitro inhibition of serotonin synthesis and shows oral efficacy in rodent models with minimal brain penetration.
- Inhibits tryptophan hydroxylase 1 and reduces peripheral serotonin production.
- Potent in vitro activity (complete inhibition reported at 1 μM in Tph1-expressing cells).
- Oral efficacy in rodent models; prevents and rescues osteoporosis in ovariectomized animals.
- Minimal brain penetration, indicating limited blood-brain barrier crossing.
- Light yellow solid with high reported purity.
- Soluble in DMSO (25 mg/mL); practically insoluble in water.
- Available as small solid quantities and as a ready-made solution for research applications.
Medchemexpress LLC YM-298198 hydrochloride | 1216398-09-2 | MFCD08703122 | ≥99.0% | 378.92 | C18H23ClN4OS | 10 MG
YM-298198 hydrochloride is the hydrochloride salt of a selective, high-affinity, non-competitive antagonist of metabotropic glutamate receptor 1 (mGluR1) supplied for research use in small quantities.
- Selective mGluR1 antagonist with Ki = 19 nM and IC50 = 16 nM in functional assays.
- High reported purity (≥99.0% for latest batches).
- Molecular formula C18H23ClN4OS and molecular weight 378.92.
- CAS number 1216398-09-2 for substance identification.
- Available in small pack sizes such as 10 mg for research applications.
- Recommended storage: -20°C sealed; in solvent: -80°C up to 6 months or -20°C up to 1 month, protected from moisture.
Medchemexpress LLC RX 801077 (hydrochloride) | 89196-95-2 | MFCD00672666 | 99.8% | 222.6708 | C11H11ClN2O | 10 MG
RX 801077 hydrochloride is a selective imidazoline I2 receptor (I2R) agonist provided for research use as a solid or as a 10 mM solution in DMSO. It is produced with high purity for pharmacological studies, including investigations of neuroprotection and anti-inflammatory mechanisms.
- Selective imidazoline I2 receptor agonist with reported Ki ≈ 70 nM.
- High purity, 99.8% as supplied.
- Available as solid and as a 10 mM solution in DMSO.
- Suitable for pharmacology, neuroprotection, and inflammation research.
- Store at 4°C; in solvent store at -80°C (6 months) or -20°C (1 month).
- Soluble in DMSO for stock solution preparation.
Medchemexpress LLC TC-A 2317 hydrochloride | 1245907-03-2 | MFCD19690936 | 99.6% | 392.93 g/mol | C19H29ClN6O | 10 MG
TC-A 2317 hydrochloride is the hydrochloride salt of TC-A 2317, a potent, orally active Aurora A kinase inhibitor characterized for cellular activity and antitumor effects. It is supplied as a high-purity research reagent suitable for in vitro and in vivo pharmacology studies.
- Potent Aurora A kinase inhibitor (Ki = 1.2 nM).
- Selective over Aurora B kinase (Ki = 101 nM) and many other kinases.
- Hydrochloride salt form for improved stability and solubility.
- High purity suitable for research (≈99.6%).
- Available in small milligram quantities for preclinical studies.
- Molecular weight 392.93 g/mol; molecular formula C19H29ClN6O.
Medchemexpress LLC Benzenepropanamine, gamma-(2-methoxyphenoxy)-N-methyl-, hydrochloride | 57754-86-6 | 99.9% | 307.82 | C17H22ClNO2 | 10 MG
Nisoxetine hydrochloride is a research-grade small molecule that potently and selectively inhibits the noradrenaline (norepinephrine) transporter (NET) and can block voltage-gated sodium channels. It is supplied as a solid powder for use in transporter pharmacology, neurotransmitter uptake assays, and sodium channel studies.
- Potent, selective noradrenaline transporter (NET) inhibitor (reported Kd ≈ 0.76 nM).
- Acts as an antidepressant-class compound and local anesthetic via sodium channel blockade.
- High purity suitable for biochemical assays and pharmacology studies.
- Available in small-scale powder sizes and DMSO solution formats for ready use.
- Stable when stored under recommended conditions (powder and in solvent).
Medchemexpress LLC 1,3-propanediol, 2-amino-2-(1-nonyl-1H-1,2,3-triazol-4-yl) hydrochloride | 2376132-24-8 | 99.9% | 320.86 | C14H29ClN4O2 | 10 MG
KARI 201 hydrochloride is a dual-action small-molecule research compound that functions as a selective, brain-penetrant acid sphingomyelinase (ASM) inhibitor and a ghrelin receptor (GHSR) agonist. It is intended for preclinical in vitro and in vivo studies and is supplied as a solid for laboratory research use only.
- Selective acid sphingomyelinase inhibitor.
- Ghrelin receptor agonist with brain penetration.
- High purity, 99.9% (HPLC).
- Molecular weight 320.86 g·mol-1.
- Supplied as a 10 mg solid; store sealed at -20°C.
- For research use only; not for human or diagnostic use.
![Medchemexpress LLC Acetamide, N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]- | 893990-34-6 | MFCD05957363 | 99.7% | 342.44 | C16H14N4OS2 | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000289016.png-250.jpg)
Medchemexpress LLC Acetamide, N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]- | 893990-34-6 | MFCD05957363 | 99.7% | 342.44 | C16H14N4OS2 | 10 MG
VU 0240551 is a small-molecule research compound that acts as a potent neuronal K+-Cl- cotransporter 2 (KCC2) inhibitor and is used in in vitro pharmacology and preclinical studies. It shows submicromolar activity at KCC2 and selectivity versus NKCC1.
- Potent KCC2 inhibitor (IC50 ≈ 560 nM).
- Selective versus NKCC1 (IC50 > 50 μM).
- High purity (99.7%).
- Molecular weight 342.44; formula C16H14N4OS2.
- White to off-white solid with high solubility in DMSO (≥ 50 mg/mL).
- Recommended storage: powder -20 °C (long-term) or 4 °C (shorter term); solvent storage at -80 °C.
- Supplied in small pack sizes suitable for research (5 mg-100 mg).
![Medchemexpress LLC N'-[[2-(2,3-dichlorophenoxy)phenyl]methyl]-N,N'-dimethylethane-1,2-diamine | 2289726-31-2 | >98.0% | 375.72 g/mol | C17H21Cl3N2O | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000288707.png-250.jpg)
Medchemexpress LLC N'-[[2-(2,3-dichlorophenoxy)phenyl]methyl]-N,N'-dimethylethane-1,2-diamine | 2289726-31-2 | >98.0% | 375.72 g/mol | C17H21Cl3N2O | 10 MG
DCPT1061 hydrochloride is a research-use small-molecule inhibitor of protein arginine methyltransferases, reported to inhibit PRMT1, PRMT6, and PRMT8. Supplied as the hydrochloride salt to improve handling and solubility, it is provided in small milligram quantities for laboratory use. Typical distributor-reported specifications include a molecular weight of 375.72 g/mol, formula C17H21Cl3N2O, and reported purity greater than 98%. Store sealed at -20°C and prepare solutions in DMSO as required.
- Reported inhibitor of PRMT1, PRMT6, and PRMT8.
- Supplied as the hydrochloride salt for improved solubility and handling.
- Molecular weight 375.72 g/mol and formula C17H21Cl3N2O.
- Purity reported greater than 98% by distributors.
- Soluble in DMSO (~50 mg/mL) with warming or sonication.
- For research use only; not for human or clinical use.
Medchemexpress LLC 4-(4-fluoronaphthalen-1-yl)-6-propan-2-ylpyrimidin-2-amine | 199864-87-4 | MFCD20270616 | 100.0% | 281.33 g/mol | C17H16FN3 | 10 MG
RS-127445 is a selective, high-affinity 5-HT2B receptor antagonist used in preclinical research. It is orally bioavailable, shows a pKi of 9.5, and is supplied as a white to off-white solid suitable for both in vitro and in vivo studies. Intended for laboratory research use only.
- Selective 5-HT2B receptor antagonist with nanomolar affinity.
- Orally bioavailable and active in vivo models.
- High chemical purity suitable for analytical and biological assays.
- Available as a solid for convenient weighing and formulation.
- Suitable for in vitro potency and selectivity profiling.