BH3 hydrochloride is a BBB-penetrated peptide that provokes apoptosis either by direct activation of pro-apoptotic Bax/Bak or by neutralizing anti-apoptotic Bcl-2 proteins (Bcl-2, Bcl-XL, Bcl-w, Mcl-1, and A-1) via their BH3 domain. It is for research use only and not sold to patients.
- BBB-penetrated peptide
- Provokes apoptosis
- Activates pro-apoptotic Bax/Bak
- Neutralizes anti-apoptotic Bcl-2 proteins
- Molecular formula: C120H183ClN36O32
- Appearance: Solid
- Color: White to off-white
- Sequence: Ile-Trp-Ile-Ala-Gln-Glu-Leu-Arg-Arg-Ile-Gly-Asp-Glu-Phe-Asn-Ala-Tyr-Tyr-Ala-Arg-Arg
- Sequence shortening: IWIAQELRRIGDEFNAYYARR
- Solubility in water: ≥ 33.33 mg/mL (12.45 mM)
- For research use only