Organofluorides
Apexbio Technology LLC Verdinexor (KPT-335) 1392136-43-4 10mM (in 1mL DMSO)
Verdinexor (KPT-335 CAS 1392136-43-4) is a selective inhibitor of nuclear export (SINE) targeting exportin-1 (XPO1) a protein that mediates nuclear export of various cargos critical in cell proliferation and cycle regulation Verdinexor treatment in influenza A- or B-infected A549 cells leads to nuclear accumulation of viral ribonucleoproteins (vRNP) and altered localization of viral NS1 protein effectively blocking nuclear export and viral replication In mouse models infected with influenza A virus verdinexor significantly reduces pulmonary viral titers and inflammatory cytokine expression Additionally verdinexor exhibits cytotoxic activity against canine lymphoma cells Therefore verdinexor serves as a valuable tool compound in antiviral and oncology research
Apexbio Technology LLC VX-222 (VCH-222, Lomibuvir) 1026785-59-0 10mg
VX-222 (VCH-222 Lomibuvir) is a non-nucleoside inhibitor of hepatitis C virus (HCV) RNA polymerase functioning through direct interaction with the polymerase enzyme It targets the thumb II allosteric pocket of the HCV RNA-dependent RNA polymerase (NS5B) mediating inhibition specifically by interfering with primer-dependent RNA synthesis rather than de novo initiation The inhibitory mechanism is attributed to hydrophobic interactions between its 4-methylcyclohexyl moiety and residues L412 M423 and I482 within the polymerase domain VX-222 demonstrates variable inhibitory activities in biochemical assays exhibiting IC50 values ranging from 0 011 to greater than 5 M depending on RNA template conditions making it suitable for antiviral mechanism and viral replication studies
Apexbio Technology LLC VX-222 (VCH-222, Lomibuvir) 1026785-59-0 100mg
VX-222 (VCH-222 Lomibuvir) is a non-nucleoside inhibitor of hepatitis C virus (HCV) RNA polymerase functioning through direct interaction with the polymerase enzyme It targets the thumb II allosteric pocket of the HCV RNA-dependent RNA polymerase (NS5B) mediating inhibition specifically by interfering with primer-dependent RNA synthesis rather than de novo initiation The inhibitory mechanism is attributed to hydrophobic interactions between its 4-methylcyclohexyl moiety and residues L412 M423 and I482 within the polymerase domain VX-222 demonstrates variable inhibitory activities in biochemical assays exhibiting IC50 values ranging from 0 011 to greater than 5 M depending on RNA template conditions making it suitable for antiviral mechanism and viral replication studies
Sigma Organic Chemistry Hexaamminecobalt(III) chloride | 100G | 10534-89-1 | MFCD00036304 | 0.99
Hexaamminecobalt(III) chloride, 100G
About This Item:
Storage: room temp
EINECS Number: 234-103-9
Sigma Organic Chemistry 1 1 1-Trifluoro-5 5-dim | 5ml | 22767-90-4 | MFCD00040841
1 1 1-Trifluoro-5 5-dim , 5ml
About this item:
CAS #: 22767-90-4
MDL #: MFCD00040841
Purity: ≥98
Molecular Weight: 196.17
UNSPSC Code: 12352100
Sigma Organic Chemistry 3 3 3-Trifluoropropioni | 5ml | 2516-99-6 | MFCD00153292
3 3 3-Trifluoropropioni , 5ml
About this item:
CAS #: 2516-99-6
MDL #: MFCD00153292
Purity: ≥98
Molecular Weight: 128.05
UNSPSC Code: 12352100
Sigma Organic Chemistry (3-Acrylamidopropyl)trimethylammonium chloride solution | 250ML | 45021-77-0 | MFCD00274249
(3-Acrylamidopropyl)trimethylammonium chloride solution, 250ML
About This Item:
Density: 1.11 g/mL at 25 C
Refractive Index: n20/D 1.4848
Storage: 2-8C
Sigma Organic Chemistry Diallyldimethylammonium chloride solution | 3L | 7398-69-8 | MFCD00043200
Diallyldimethylammonium chloride solution, 3L
About This Item:
Storage: room temp
Sigma Organic Chemistry Heptafluoro-2-iodopropane | 25G | 677-69-0 | MFCD00042089
CAS #: 677-69-0
MDL #: MFCD00042089
Purity: >98 %
UNSPSC Code: 12352100
Molecular Weight: 295.93
Sigma Organic Chemistry 2,6,6-Trimethyl-2-cyclohexene-1,4-dione | 25G | 1125-21-9 | MFCD00043119
CAS #: 1125-21-9
MDL #: MFCD00043119
Purity: >98 %
UNSPSC Code: 12352100
Molecular Weight: 152.19
Sigma Organic Chemistry 2-Cyano-6-methoxybenzothiazole | 1G | 943-03-3 | MFCD00010537
CAS #: 943-03-3
MDL #: MFCD00010537
Purity: >99 %
UNSPSC Code: 12352100
Molecular Weight: 190.22
Sigma Organic Chemistry Ethyl trans-alpha-cyanocinnamate | 5G | 2169-69-9 | MFCD00009137
CAS #: 2169-69-9
MDL #: MFCD00009137
Purity: >99 %
UNSPSC Code: 12352100
Molecular Weight: 201.22
Matrix Scientific 1H,1H,2H-PERFLUORO-1-OCTEN-25G
1H, 1H,2H-Perfluoro-1-octene, 98%; 25g,C8H3F13, MFCD00039249, mw 346.09, [25291-17-2]
Matrix Scientific 3,3,3-TRIFLUOROPROPIONIC AC-5G
3, 3,3-Trifluoropropionic acid, 98%; 5g,C3H3F3O2, MFCD00153292, mw 128.05, [2516-99-6]