Organofluorides
Medchemexpress LLC Cyclo(RADfK) | 756500-23-9 | >96.4% | 617.70 | 25 MG
Cyclo(RADfK) serves as a negative control for Cyclo(-RGDfK). It is useful in studies involving RGD peptides, which are known modulators of cell adhesion and are recognized by various members of the integrin family.
- Functions as a negative control for RGD peptides
- Modulates cell adhesion
- Recognized by integrin family members
- Soluble in water and PBS at 100 mg/mL
- Targets integrin
- Involved in cytoskeleton pathway
Medchemexpress LLC Cyclo(RADfK) | 756500-23-9 | 96.4% | 617.70 | 10 MG
Cyclo(RADfK) is a negative control for cyclo(-RGDfK), a RGD peptide known to modulate cell adhesion and interact with integrin family members. It can be used as a control for studies involving Cyclo(-RGDfK).
- Serves as a negative control for RGD peptides
- Modulates cell adhesion properties
- Recognized by integrin family members
- Provided as a white to off-white solid
- Soluble in H2O and PBS (100 mg/mL), requiring sonication
Apexbio Technology LLC Verdinexor (KPT-335) 1392136-43-4 10mM (in 1mL DMSO)
Verdinexor (KPT-335 CAS 1392136-43-4) is a selective inhibitor of nuclear export (SINE) targeting exportin-1 (XPO1) a protein that mediates nuclear export of various cargos critical in cell proliferation and cycle regulation Verdinexor treatment in influenza A- or B-infected A549 cells leads to nuclear accumulation of viral ribonucleoproteins (vRNP) and altered localization of viral NS1 protein effectively blocking nuclear export and viral replication In mouse models infected with influenza A virus verdinexor significantly reduces pulmonary viral titers and inflammatory cytokine expression Additionally verdinexor exhibits cytotoxic activity against canine lymphoma cells Therefore verdinexor serves as a valuable tool compound in antiviral and oncology research
Medchemexpress LLC 4'-Trifluoromethyl-2-biphenyl carboxylic acid | 84392-17-6 | 99.9% | 266.22 | 5 G
4'-Trifluoromethyl-2-biphenyl carboxylic acid is an orally active hypolipidemic agent, suitable for research purposes. It has demonstrated hypolipidemic activity in diet-induced hypercholesterolemic African green monkeys, leading to reduced serum LDL-cholesterol concentrations. This compound appears as a white to off-white solid.
- Orally active hypolipidemic agent
- Shows hypolipidemic activity in diet-induced hypercholesterolemic African green monkeys
- Reduces serum LDL-cholesterol concentrations
- White to off-white solid appearance
- Soluble in DMSO (100 mg/mL)
- Insoluble in H2O (< 0.1 mg/mL)
Medchemexpress LLC MI-463 | 1628317-18-9 | 99.7% | 484.54 | 1 ML
MI-463 is a highly potent and orally bioavailable small molecule inhibitor of the menin-mLL interaction.
- Effectively inhibits the menin-mLL-AF9 interaction at sub-micromolar concentrations in mammalian cells.
- Achieves high level in peripheral blood following a single intravenous or oral dose, with high oral bioavailability (45%).
- Induces strong inhibition of tumor growth with once daily intraperitoneal (i.p.) administration.
- Reduces expression of mLL fusion protein target genes, HOXA9 and MEIS1.
- Delays progression of mLL leukemia in murine models through on-target activity without causing toxicity.
- Leads to a substantial delay in leukemia progression in MV4;11 xenograft recipient mice.
Medchemexpress LLC Cyclo(Arg-Pro) TFA | 98.6% | 367.32 | 10 MG
Cyclo(Arg-Pro) TFA is a chitinase inhibitor that disrupts cell separation and morphological transition of yeast by inhibiting chitinase activity. It prevents cell separation of Saccharomyces cerevisiae, leading to the formation of grape-like cell clusters without inhibiting cell growth. Additionally, it blocks the morphological transition of Candida albicans from yeast form to hyphal form, also without inhibiting cell growth.
- Chitinase inhibitor.
- Disrupts cell separation and morphological transition of yeast.
- Prevents cell separation of Saccharomyces cerevisiae without inhibiting cell growth.
- Blocks morphological transition of Candida albicans from yeast to hyphal form without inhibiting cell growth.
- For research use only.