Organophosphorus compounds
Medchemexpress LLC rno-miR-223-3p antag 20nmol | 20nmol
rno-miR-223-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs The miRNA antagomirs have 2 phosphorothioates at the 5 end 4 phosphorothioates at the 3 end 1 cholesterol group at the 3 end and full-length nucleotide 2 -methoxy modification The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes thereby inhibiting miRNAs from functioning Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors they exhibits enhanced cellular uptake stability and regulatory activity in vivo
Medchemexpress LLC YKL-1-116 5mg | 1957202-71-9 | 606.72 | C34H38N8O3 | 5 MG
YKL-1-116 is a selective, covalent inhibitor of cyclin-dependent kinase 7 (CDK7) used in laboratory research to probe CDK7-dependent cell cycle and transcriptional processes. It is more potent than related inhibitors against CDK7 and shows limited activity against CDK9, CDK12, and CDK13. Supplied as a small, high-purity solid for research use only (not for human consumption).
- Selective covalent inhibitor of CDK7.
- Higher potency against CDK7 compared with related compounds.
- Minimal activity against CDK9, CDK12, and CDK13.
- High reported purity (~98.7%).
- Provided as a small solid quantity suitable for in vitro research.
- Molecular weight 606.72 and formula C34H38N8O3.
Medchemexpress LLC EMU-116 | 2241724-59-2 | 98.53% | 405.58 | 25 MG
EMU-116 is an orally active CXCR4 antagonist. It is utilized in cancer research.
- Orally active CXCR4 antagonist
- Can be used in cancer research
- Purity of 98.53%
- Molecular weight of 405.58
- Appears as a solid
- Color is light yellow to yellow
- Powder storage at -20°C for 3 years, 4°C for 2 years
- In solvent storage at -80°C for 6 months, -20°C for 1 month
- Soluble in DMSO at 100 mg/mL
- Multiple in vivo dissolution protocols available
Medchemexpress LLC hsa-miR-195-3p inhib 5nmol | 5nmol
hsa-miR-195-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs The miRNA inhibitors have full-length nucleotide 2 -methoxy modification The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes thereby inhibiting miRNAs from functioning
Medchemexpress LLC mmu-miR-378a-3p inhi 5nmol | 5nmol
mmu-miR-378a-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs The miRNA inhibitors have full-length nucleotide 2 -methoxy modification The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes thereby inhibiting miRNAs from functioning
![Medchemexpress LLC 4-methyl-5-[2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]-1,3-thiazol-2-amine | 693228-63-6 | MFCD14155805 | 99.5% | 368.46 g/mol | C18H20N6OS | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000240040.png-250.jpg)
Medchemexpress LLC 4-methyl-5-[2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]-1,3-thiazol-2-amine | 693228-63-6 | MFCD14155805 | 99.5% | 368.46 g/mol | C18H20N6OS | 5 MG
CYC-116 is a small-molecule research compound that selectively inhibits Aurora kinases A and B. It is used to probe cell cycle regulation and anticancer mechanisms in biochemical and cellular assays, and is supplied in solid and solution formats for laboratory use.
- Potent inhibition of Aurora A and B (Ki ≈ 8 nM and 9.2 nM).
- Suitable for biochemical and cellular assays.
- Available as solid and as DMSO solution for convenient dosing.
- Molecular weight 368.46 g/mol; molecular formula C18H20N6OS.
- High reported purity (≈99.5%) for research applications.
Medchemexpress LLC hsa-miR-214-3p mimic 5nmol | 5nmol
hsa-miR-214-3p mimics are small chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity
Medchemexpress LLC hsa-miR-185-3p mimic 5nmol | 5nmol
hsa-miR-185-3p mimics are small chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity
Medchemexpress LLC hsa-miR-30e-3p mimic 5nmol | 5nmol
hsa-miR-30e-3p mimics are small chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity
Medchemexpress LLC DGY-06-116 | 2556836-50-9 | 98.6% | 597.11 | 1 ML
DGY-06-116 is an irreversible covalent, selective Src inhibitor with an IC50 of 3nM. It also demonstrates inhibitory activity against FGFR1. This compound exhibits potent antiproliferative effects in various cancer cell lines, including nonsmall cell lung cancer (NSCLC) and triple negative breast cancer (TNBC), by inhibiting SRC signaling.
- Potent and selective Src inhibitor (IC50: 3 nM)
- Irreversible covalent mechanism
- Inhibits Src kinase activity with an IC50 of 2.6 nM at 1 hour incubation
- Demonstrates antiproliferative effects in H1975, HCC827, and MDA-MB-231 cell lines
- Induces potent SRC binding and inhibition of SRC signaling
- Inhibits p-SRCY416 signaling in NSCLC cells
- Exhibits in vivo efficacy in adult C57B6 mice, inhibiting SRC for an extended duration