Vinyl halides
Medchemexpress LLC AS-Inclisiran sodium | 94.3% | C237H291F10N101O134P22S4 | 1 MG
AS-Inclisiran sodium is the antisense of Inclisiran, a double-stranded small interfering RNA (siRNA) molecule that inhibits the transcription of PCSK9. It also inhibits Pyroptosis, activates PPARγ, and reduces NLRP3, cleaved caspase-1, IL-1β, and IL-18. It possesses anti-inflammatory, lipid-regulating, and anti-atherosclerotic activities. AS-Inclisiran sodium, as the antisense strand, lacks the complementary strand and its GalNAc modification, and therefore has no liver targeting property. It is for research use only and not sold to patients.
- Antisense of Inclisiran
- Inhibits transcription of PCSK9
- Inhibits pyroptosis
- Activates PPARγ
- Reduces NLRP3, cleaved caspase-1, IL-1β, and IL-18
- Possesses anti-inflammatory, lipid-regulating, and anti-atherosclerotic activities
- Lacks liver targeting property
eMolecules 5459-35-8 | ETHYL 2-BROMOACRYLATE | AstaTech | MFCD02258596 | 179.013 | C5H7BrO2 | 95.000 | CCOC(=O)C(Br)=C | 0.25g | 796988741
ETHYL 2-BROMOACRYLATE | AstaTech | 5459-35-8 | MFCD02258596 | 179.013 | C5H7BrO2 | 95.000 | CCOC(=O)C(Br)=C | 0.25g | 796988741
Medchemexpress LLC Trans-2-butene-1,4-dicarboxylic acid | 4436-74-2 | 99.8% | 500 MG
Trans-2-butene-1,4-dicarboxylic acid (Dihydromuconic acid; trans-β-Hydromuconic acid) is an endogenous metabolite. It is a metabolite for organic acidurias that can be found in urine.
- Endogenous metabolite
- Useful for research
- Can be found in urine
eMolecules 10485-09-3 | 2-Bromoindene | Ambeed | MFCD06797863 | 195.059 | C9H7Br | 98.000 | BrC1=Cc2ccccc2C1 | 1g | 552527369
2-Bromoindene | Ambeed | 10485-09-3 | MFCD06797863 | 195.059 | C9H7Br | 98.000 | BrC1=Cc2ccccc2C1 | 1g | 552527369
Medchemexpress LLC Prexigebersen sodium | 202484-91-1 | 95.6% | 5520.6 (free acid) | C177H206N63Na18O110P17 | 10 MG
Prexigebersen sodium is a liposomal-formulated antisense oligonucleotide designed to inhibit synthesis of the adaptor protein Grb2. Supplied as a characterized sodium salt for research use, it is intended for preclinical studies of Grb2-mediated signaling pathways and oncology-related investigations.
- Antisense oligonucleotide targeting Grb2.
- Liposomal formulation for enhanced delivery.
- Sodium salt form for aqueous solubility.
- High purity suitable for research applications.
- Available in small-scale research quantities.
- Includes documentation: datasheet, SDS, COA, and LCMS.
Medchemexpress LLC Thioglycolate sodiu 10g
Thioglycolate sodium is used in inflammation research to elicit a neutrophil and macrophage response in vivo Thioglycolate sodium can induce peritonitis in vivo[1][2]
Medchemexpress LLC TX1-85-1 | 1603845-32-4 | 99.7% | 580.68 | 1 MG
TX1-85-1 is an irreversible Her3 (ErbB3) inhibitor with an IC50 of 23 nM. It acts as the first selective Her3 ligand, forming a covalent bond with Cys721 in the ATP-binding site of Her3. This compound induces partial degradation of Her3 protein and attenuates Her3-dependent signaling, showing anti-proliferation effects in various cell lines.
- Irreversible Her3 (ErbB3) inhibitor with an IC50 of 23 nM
- First selective Her3 ligand forming a covalent bond with Cys721
- Induces partial degradation of Her3 protein
- Attenuates Her3-dependent signaling
- Demonstrates anti-proliferation EC50s of 9.9, 11.5, and 16.9 μM for Ovcar8, HCC827 GR6, and PC9 GR4 cells, respectively
Sigma Aldrich Fine Chemicals Biosciences 3 3-DIMETHYL-1-BUTENE 97 GC
NC3739483 3 3-DIMETHYL-1-BUTENE 97 GC
Cayman Chemical DmyoInositol3phosphate sodiu
Synthetic, pure phosphoinositol for signal transduction research; can be formed by the dephosphorylation of polyphosphate inositols such as Ins(3,4)P2 by inositol polyphosphate 4-phosphatase
Cayman Chemical DmyoInositol1phosphate sodiu
A synthetic, pure phosphoinositol for signal transduction research; can be formed by PLC hydrolysis of phosphatidylinositol or by dephosphorylation of polyphosphate inositols such as Ins(1,3)P2 by inositol polyphosphate 3-phosphatase
3,6-Dichloropyridazine-4-carboxylic acid, 98%, Thermo Scientific™
CAS: 51149-08-7 Molecular Formula: C5H2Cl2N2O2 Molecular Weight (g/mol): 192.98 MDL Number: MFCD00011575 InChI Key: FRCXPDWDMAYSCE-UHFFFAOYSA-N Synonym: 3,6-dichloro-4-pyridazinecarboxylic acid,3,6-dichloropyridazine-4-carboxylicacid,4-pyridazinecarboxylic acid, 3,6-dichloro,3,6-dichloropyridazinecarboxylic acid,3,6-dichloro-pyridazine-4-carboxylic acid,pubchem9529,enamine_001708,acmc-1ay8l,ksc269c3r,4-carboxy-3,6-dichloropyridazine PubChem CID: 433804 IUPAC Name: 3,6-dichloropyridazine-4-carboxylic acid SMILES: OC(=O)C1=CC(Cl)=NN=C1Cl
Methyl 3-bromothiophene-2-carboxylate, 97%, Thermo Scientific™
CAS: 26137-08-6 Molecular Formula: C6H5BrO2S Molecular Weight (g/mol): 221.068 MDL Number: MFCD00173839 InChI Key: PEGSJNCGPSIJOX-UHFFFAOYSA-N Synonym: 3-bromothiophene-2-carboxylic acid methyl ester,3-bromo-thiophene-2-carboxylic acid methyl ester,2-thiophenecarboxylic acid, 3-bromo-, methyl ester,3-bromo-2-thiophenecarboxylic acid methyl ester,methyl 3-bromo-2-thiophenecarboxylate,maybridge3_006386,ksc494q2p,2-methoxycarbonyl-3-bromothiophene,methyl-3-bromothiophene carboxylate,methyl 3-bromanylthiophene-2-carboxylate PubChem CID: 2740074 IUPAC Name: methyl 3-bromothiophene-2-carboxylate SMILES: COC(=O)C1=C(C=CS1)Br
1,2-Dibromoethylene, Mixture of cis and trans 98%, Thermo Scientific™
CAS: 540-49-8 Molecular Formula: C2H2Br2 Molecular Weight (g/mol): 185.846 InChI Key: UWTUEMKLYAGTNQ-UPHRSURJSA-N Synonym: ethene, 1,2-dibromo-, z,unii-0s4d0712fy,acetylene dibromide,z-1,2-dibromoethene,1,2-dibromoethylene,cis-dibromoethylene,1,2-dibromoethylene, 1z,cis-dibromoethene,ethene,2-dibromo,ethylene,2-dibromo PubChem CID: 643776 IUPAC Name: (Z)-1,2-dibromoethene SMILES: C(=CBr)Br
![Methyl 7-bromo-3-chloro-4-fluorobenzo[b]thiophene-2-carboxylate, 97%, Thermo Scientific™](https://assets.fishersci.com/TFS-Assets/CCG/Chemical-Structures/chemical-structure-cas-1823304-13-7.jpg-250.jpg)
Methyl 7-bromo-3-chloro-4-fluorobenzo[b]thiophene-2-carboxylate, 97%, Thermo Scientific™
CAS: 1823304-13-7 Molecular Formula: C10H5BrClFO2S Molecular Weight (g/mol): 323.56 MDL Number: MFCD23380840 InChI Key: UHFJFXCPHLTILG-UHFFFAOYSA-N Synonym: 7-Bromo-3-chloro-4-fluorobenzo[b]thiophene-2-carboxylic acidmethyl ester PubChem CID: 98001137 IUPAC Name: methyl 7-bromo-3-chloro-4-fluoro-1-benzothiophene-2-carboxylate SMILES: COC(=O)C1=C(C2=C(C=CC(=C2S1)Br)F)Cl