Organo-Metalloid Compounds
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Filtered Search Results
Medchemexpress LLC Pomalidomide 4'-PEG3-azide | 2271036-46-3 | 96.3% | 100 MG
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Pomalidomide 4'-PEG3-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates a Pomalidomide-based cereblon ligand and a linker. It is used for the synthesis of iRucaparib-TP3, a highly efficient PARP1 degrader developed using the PROTAC approach. This compound is also a click chemistry reagent containing an Azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions.
- E3 ligase ligand-linker conjugate
- Incorporates a Pomalidomide-based cereblon ligand
- Utilized for synthesis of iRucaparib-TP3
- Highly efficient PARP1 degrader
- Click chemistry reagent with an azide group
- Enables copper-catalyzed azide-alkyne cycloaddition reactions
- Enables strain-promoted alkyne-azide cycloaddition reactions
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Medchemexpress LLC N- Azido-PEG3 -N-bis | 100MG
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N- Azido-PEG3 -N-bis | 100MG
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Medchemexpress LLC PEG3-C4-OBn | 2381196-79-6 | 99.3% | 100 MG
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PEG3-C4-OBn is a polyethylene glycol (PEG)-based PROTAC linker. It can be used in the synthesis of the PROTAC SGK3 degrader-1, which is a potent SKG3 degrader.
- Polyethylene glycol (PEG)-based PROTAC linker
- Used in the synthesis of PROTAC SGK3 degrader-1
- High solubility in DMSO (≥ 100 mg/mL)
- Long-term stability in pure form at -20°C (3 years) and 4°C (2 years)
- Extended stability in solvent at -80°C (6 months) and -20°C (1 month)
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Medchemexpress LLC Azido-PEG5-acid | 1425973-16-5 | MFCD23726612 | >98.0% | 335.35 g/mol | C13H25N3O7 | 100 MG
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Azido-PEG5-acid is an azide-terminated polyethylene glycol (PEG5) linker designed for click chemistry and bioconjugation. It features a terminal carboxylic acid and an azide functional group that enable copper-catalyzed azide-alkyne cycloaddition (CuAAC) and strain-promoted azide-alkyne cycloaddition (SPAAC), making it useful for PROTAC construction, ADC linker assembly, and general spacer chemistry.
- Azide-terminated PEG5 spacer for bioconjugation
- Compatible with CuAAC and SPAAC click reactions
- High purity for reliable coupling
- Colorless to light yellow liquid, easy to handle
- Stable under recommended storage conditions
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Medchemexpress LLC Bis-PEG5-acid 10g | 439114-13-3 | 338.35 g/mol | C14H26O9 | 10 G
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Bis-PEG5-acid is a polyethylene glycol (PEG) linker with two terminal carboxylic acid groups used to assemble PROTACs and other bifunctional molecules. The hydrophilic spacer increases aqueous solubility and provides flexible separation between ligands for conjugation chemistry.
- Two terminal carboxylic acid groups for conjugation.
- Hydrophilic PEG spacer improves solubility in aqueous media.
- Flexible linker suitable for PROTAC and bifunctional molecule assembly.
- Available in multiple package sizes including 10 G.
- Solid material with white to yellow appearance.
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Medchemexpress LLC 4,7,10-trioxa-3-siladodecan-12-ol, 2,2,3,3-tetramethyl- | 201037-95-8 | MFCD30471718 | ≥98.0% | 264.43 g/mol | C12H28O4Si | 10 G
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TBDMS-PEG3-OH is a polyethylene glycol (PEG) derivative used in chemical and pharmaceutical research, commonly as a linker or modifier in drug-delivery constructs and PROTAC synthesis. It is supplied as a colorless to light-yellow liquid and is typically provided at research-grade purity.
- Has a molecular weight of 264.43 g/mol.
- Chemical formula C12H28O4Si.
- CAS number 201037-95-8.
- Purity ≥98.0%.
- Supplied as a colorless to light-yellow liquid.
- Typical pack size 10 g.
- Useful as a PEG linker or modifier in drug-delivery and PROTAC synthesis.
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Medchemexpress LLC 2,4-D isooctyl ester | 25168-26-7 | 97.2% | 10 MM 1 ML
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2,4-D isooctyl ester is a selective herbicide of the chlorophenoxy compound family, known for its higher boiling point, low volatility, and minimal drift. It is effective in managing broadleaf weeds across various environments, including crops, lawns, and forests.
- Selective herbicide
- Chlorophenoxy compound
- Higher boiling point
- Low volatility
- Minimal drift
- Utilized to manage broadleaf weeds
- Suitable for use in crops, lawns, and forests
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Medchemexpress LLC Bis-PEG5-PFP ester | 1334177-78-4 | 100 MG
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Bis-PEG5-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
- Contains two different ligands connected by a linker.
- One ligand targets an E3 ubiquitin ligase; the other targets the protein.
- Exploits the intracellular ubiquitin-proteasome system.
- Selectively degrades target proteins.
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Medchemexpress LLC Acetic acid, 2-(2,4-dichlorophenoxy)-, isooctyl ester | 25168-26-7 | 97.2% | 100 MG
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2,4-D isooctyl ester is a selective herbicide of the chlorophenoxy compound class. It features a higher boiling point, low volatility, and low drift, making it suitable for controlling broadleaf weeds in various environments such as crops, lawns, and forests. It is for research use only.
- Selective herbicide of chlorophenoxy compound class
- Higher boiling point
- Low volatility
- Low drift
- Controls broadleaf weeds in crops, lawns, and forests
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Medchemexpress LLC Peg3-C4-Obn | 2381196-79-6 | 99.3% | 25 MG
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PEG3-C4-OBn is a polyethylene glycol (PEG)-based PROTAC linker. It is utilized in the synthesis of a potent SKG3 degrader based on PROTAC.
- Liquid appearance
- Colorless to light yellow
- Purity of 99.3%
- Molecular weight of 296.40
- Molecular formula C17H28O4
- Used as a PROTAC linker
- Soluble in DMSO: ≥ 100 mg/mL
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Medchemexpress LLC Lipoamide-PEG3-mal | 1314378-19-2 | 99.6% | C25H41N3O7S2 | 10MG
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Lipoamide-PEG3-Mal is a PEG-based linker that combines a lipoamide (lipoic acid derivative) moiety with a terminal maleimide. It is supplied for research use as a building block in the synthesis of PROTACs and other bioconjugates, providing flexible spacing and a thiol-reactive handle for selective conjugation.
- Peg3 spacer provides flexibility and improved solubility.
- Lipoamide moiety offers a bio-relevant functional group for linkage.
- Maleimide group enables rapid and selective thiol conjugation.
- High reported purity suitable for synthetic applications.
- Available in small, research-friendly package sizes.
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Medchemexpress LLC Lipoamide-PEG3-Mal | 1314378-19-2 | 99.6% | C25H41N3O7S2 | 1 MG
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Lipoamide-PEG3-Mal is a PEG-based PROTAC linker designed for the synthesis of PROTACs. These molecules feature two distinct ligands connected by a linker: one targeting an E3 ubiquitin ligase and the other binding to a specific target protein. This mechanism exploits the intracellular ubiquitin-proteasome system to facilitate the selective degradation of target proteins.
- PEG-based linker
- Used in the synthesis of PROTACs
- Contains two different ligands connected by a linker
- One ligand targets an E3 ubiquitin ligase
- Other ligand targets the target protein
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
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Medchemexpress LLC T-Boc-aminooxy-PEG5-azide | 2250216-95-4 | 95.0% | C17H34N4O8 | 100 MG
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T-Boc-Aminooxy-PEG5-azide is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. It functions as a versatile click chemistry reagent, enabling efficient conjugation with various molecules.
- Functions as a click chemistry reagent
- Contains an azide group for copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions
- Compatible with molecules containing alkyne groups
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
- Reacts with molecules containing DBCO or BCN groups
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Medchemexpress LLC 2-(2-(2-((6-chlorohexyl)oxy)ethoxy)ethoxy)ethan-1-ol | 1355955-95-1 | MFCD32705069 | 268.78 g·mol^-1 | C12H25ClO4 | 100 MG
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HO-PEG3-(CH2)6-Cl (2-(2-(2-((6-chlorohexyl)oxy)ethoxy)ethoxy)ethan-1-ol) is a hydroxy-terminated PEG3 linker bearing a 6-chlorohexyl reactive handle. It is used as a flexible, hydrophilic spacer in the synthesis of PROTACs and Halo-tag targeting conjugates, enabling attachment between target-binding ligands and recruitment motifs.
- Hydroxy-terminated PEG3 spacer with a 6-chlorohexyl functional group.
- Molecular formula C12H25ClO4; molecular weight 268.78 g·mol^-1.
- Designed for use in PROTAC and Halo-tag conjugate synthesis.
- Available in multiple pack sizes including 100 MG.
- Analytical documentation available on request (CoA, H NMR, SDS).
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Medchemexpress LLC (S,R,S)-AHPC-PEG3-NH2 hydrochloride | 2097971-11-2 | MFCD31656714 | 99.0% | 656.23 g/mol | C30H46ClN5O7S | 500 MG
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(S,R,S)-AHPC-PEG3-NH2 hydrochloride is an E3 ligase ligand-linker conjugate that combines an (S,R,S)-AHPC-based VHL ligand with a three-unit polyethylene glycol (PEG3) linker terminating in a primary amine. It is supplied as the hydrochloride salt and is used as a building block in PROTAC synthesis and other chemical biology applications.
- E3 ligase VHL ligand-linker conjugate for targeted protein degradation research.
- PEG3 linker with terminal primary amine suitable for conjugation.
- Hydrochloride salt form for improved stability and handling.
- High purity (≈99%) suitable for synthetic applications.
- Available in multiple preweighed sizes including 500 MG.
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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