Dimethyl Sulfoxide
Apexbio Technology LLC UNC0638 1255580-76-7 10mM (in 1mL DMSO)
UNC0638 is a selective inhibitor of histone methyltransferases G9a and GLP enzymes responsible for mono- and dimethylation of histone H3 lysine-9 (H3K9) It inhibits G9a and GLP activity with IC50 values of 15 nM and 19 nM respectively UNC0638 reduces cellular H3K9 dimethylation levels demonstrated in MDA-MB-231 cells with an IC50 of 81 9 nM at 48 hours It has been utilized in models to study epigenetic regulation including neuroendocrine tumor xenografts and hair cell damage induced by aminoglycosides addressing roles of H3K9 methylation in disease pathogenesis and therapeutic responses
Apexbio Technology LLC Dofetilide 115256-11-6 10mM (in 1mL DMSO)
Dofetilide (CAS 115256-11-6) chemically designated as UK 68789 is a class III antiarrhythmic small molecule that selectively inhibits the rapid delayed rectifier potassium channel (IKr) This inhibition leads to prolonged ventricular action potential duration and extended effective refractory periods in cardiac cells Noted for favorable oral bioavailability Dofetilide is extensively utilized in cardiac electrophysiological research including studies aimed at elucidating arrhythmogenic mechanisms linked to IKr channel function assessing novel antiarrhythmic candidates and exploring physiological and pathological aspects of cardiac rhythm regulation
Apexbio Technology LLC Peramivir(Synonyms: Rapivab, BCX-1812, RWJ-270201, Peramiflu), 10mM (in 1mL DMSO), CAS: 330600-85-6.
Peramivir (CAS 330600-85-6) is a neuraminidase inhibitor under investigation for antiviral activity against influenza virus Structurally peramivir functions as a transition-state analogue inhibitor selectively targeting viral neuraminidase to obstruct enzymatic cleavage required for virion release from infected host cells By this action peramivir effectively impedes viral propagation It has undergone clinical evaluation in research contexts notably receiving emergency use authorization for hospitalized patients during the 2009 H1N1 influenza pandemic
Medchemexpress LLC Docosahexnc Acid 10Mm-1Ml Dmso | HY-B2167-10MM-1ML DMSO
Docosahexnc Acid 10Mm-1Ml Dmso
Apexbio Technology LLC GSK2334470 1227911-45-6 10mM (in 1mL DMSO)
GSK2334470 (CAS 1227911-45-6) is a highly selective inhibitor of 3-phosphoinositide-dependent protein kinase-1 (PDK1) demonstrating an IC50 of approximately 10 nM It specifically blocks PDK1-mediated phosphorylation of substrate proteins including Akt1 S6K1 and SGK isoforms inhibiting their T-loop phosphorylation sites GSK2334470 does not significantly inhibit other tested protein or lipid kinases This compound facilitates mechanistic research into signaling pathways regulated by PDK1 particularly those involving Akt and downstream effectors in cellular contexts
Apexbio Technology LLC Elesclomol (STA-4783) 488832-69-5 10mM (in 1mL DMSO)
Elesclomol (STA-4783 CAS 488832-69-5) is a small molecule identified through phenotype-based screens for apoptotic activity which induces apoptosis in cancer cells by elevating intracellular reactive oxygen species (ROS) Its primary cellular target is mitochondrial electron transport disruption of which results in rapid accumulation of oxidative stress exceeding adaptive thresholds and ultimately triggering apoptotic cell death Elesclomol demonstrates antitumor activity across diverse human tumor xenograft models and is currently studied as an investigational anticancer compound capable of extending progression-free survival
Apexbio Technology LLC Ondansetron hydrochloride dihydrate 103639-04-9 10mM (in 1mL DMSO)
Ondansetron hydrochloride dihydrate (CAS 103639-04-9) is a small molecule antagonist targeting the serotonin (5-HT3) receptor a ligand-gated ion channel prominent in the central and peripheral nervous systems Through blockade of 5-HT3 receptor signaling ondansetron inhibits serotonin-induced emetic responses Due to this mechanism it is widely utilized in biomedical research investigating serotonin-related signaling pathways and nausea mechanisms particularly in contexts involving chemotherapy-induced emesis
Apexbio Technology LLC PD123319 130663-39-7 10mM (in 1mL DMSO)
PD123319 (CAS 130663-39-7) is a non-peptide antagonist targeting angiotensin II (Ang II) receptors particularly the AT2 receptor subtype It binds selectively exhibiting an IC50 of 34 nM in rat adrenal assays and 210 nM in rat brain binding assays Additionally PD123319 inhibits Ang II binding to bovine adrenal glomerulosa microsomal preparations with an IC50 of 6 9 nM Its antagonistic activity leads to reduced cyclic GMP synthesis and elevated prostaglandin E2 production without altering protein tyrosine phosphorylation or thymidine incorporation mediated by Ang II PD123319 serves as a useful pharmacological tool in investigating Ang II receptor signaling pathways
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide for molecular biology | 67-68-5 | MFCD00002089 | 50ml
Dimethyl sulfoxide for molecular biology | Mol Wt: 78.13 | 67-68-5 | MFCD00002089 | 50ml
Apexbio Technology LLC Bikinin(Synonyms: Bikinin, GSK3 Inhibitor VII, Glycogen Synthase Kinase-3 Inhibitor VII, GSK-3 Inhibitor VII), 10mM (in 1mL DMSO), CAS: 188011-69-0.
Bikinin (CAS 188011-69-0) is a small molecule inhibitor targeting glycogen synthase kinase 3 (GSK3)-like kinases particularly BIN2 thereby activating brassinosteroid (BR) signaling pathways downstream of the BRI1 receptor BR signaling regulates plant developmental processes including stem elongation vascular cell differentiation leaf expansion and stress responses Treatment with Bikinin can phenotypically rescue BR-insensitive mutants in Arabidopsis by restoring BR-dependent gene expression Additionally Bikinin usage promotes xylem cell differentiation in Nicotiana benthamiana leaf disk culture suggesting utility across different biological models
Apexbio Technology LLC DMOG 89464-63-1 10mM (in 1mL DMSO)
DMOG (Dimethyloxalylglycine CAS 89464-63-1) is a small molecule inhibitor of prolyl-4-hydroxylase domain (PHD) enzymes thereby modulating the stability of hypoxia-inducible factor (HIF) PHD inhibition by DMOG prevents HIF-1 prolyl hydroxylation and subsequent degradation stabilizing HIF-1 protein even under normoxic conditions (0 1 1 mmol/L in vitro) Additionally DMOG treatment suppresses NF- B signaling during LPS-induced inflammatory responses in animal models improving survival rates and enhancing IL-10 expression predominantly in peritoneal B-1 cells Thus DMOG serves as a valuable research tool to explore hypoxia signaling pathways and inflammatory responses
Apexbio Technology LLC Topotecan HCl 119413-54-6 10mM (in 1mL DMSO)
Topotecan HCl (CAS 119413-54-6) also known as SKF104864 is a semisynthetic derivative of camptothecin functioning as a selective inhibitor of topoisomerase I It stabilizes the topoisomerase I-DNA cleavage complex causing DNA damage and subsequent cell death Preclinical studies in murine tumor models demonstrate notable antitumor activity particularly against intravenous P388 leukemia and Lewis lung carcinoma when administered intravenously or in subcutaneous xenografts Additionally it exhibits efficacy against solid tumors including drug-resistant cancers and HT-29 human colon carcinoma xenografts Toxicological evaluations indicate reversible and concentration-dependent toxic effects primarily impacting rapidly proliferating tissues such as bone marrow and gastrointestinal epithelium
Apexbio Technology LLC Orlistat(Synonyms: Xenical, Alli, tetrahydrolipstatin, THL, Roche Xenical, lipase inhibitor, (-)-tetrahydrolipstatin), 10mM (in 1mL DMSO), CAS: 96829-58-2.
Orlistat (CAS 96829-58-2) also referred to as tetrahydrolipstatin is a synthetic derivative of lipstatin originally isolated from Streptomyces toxytricini This small molecule specifically inhibits gastrointestinal lipases particularly pancreatic lipase impeding enzymatic hydrolysis of dietary triglycerides and consequently decreasing intestinal absorption of fat Due to its targeted lipase inhibition Orlistat is widely studied in obesity-related metabolic research and lipid metabolism investigations providing a valuable experimental tool for evaluating effects of reduced dietary fat uptake and downstream physiological responses