Tetrahydrofuran
Medchemexpress LLC SJ10542 | 2789678-92-6 | 99.3% | C41H46N12O5S | 50 MG
SJ10542 is a potent and selective JAK2/3 PROTAC degrader. In PDX cells lSJBALL020589, SJ10542 has DC50 values of 14 and 11 nM for JAK2 and JAK3, respectively. It exhibits antitumor activity and can be used for the research of hematological malignancies and autoimmune diseases.
- Potent and selective JAK2/3 PROTAC degrader
- Exhibits antitumor activity
- Useful for research of hematological malignancies and autoimmune diseases
- Degrades JAK2 (DC50: 24 nM), JAK3, and GSPT1 in MHH-CALL-4 cells
- JAK2 DC50: 14 nM
- JAK3 DC50: 11 nM
- JAK2-fusion ALL DC50: 24 nM
- CRBN recruiter
Medchemexpress LLC VPC-70619 | 2361742-30-3 | 99.93% | C16H8ClF3N4O | 100 MG
VPC-70619 is a potent N-Myc inhibitor that blocks the binding of the N-Myc-Max heterocomplex to the DNA E-box and shows strong inhibitory activity against N-Myc-dependent cell lines. It can partially reverse paclitaxel resistance in cells by reducing MYCN expression and can be used for cancer research, including neuroblastoma and thyroid cancer.
- Potent N-Myc inhibitor
- Blocks the binding of the N-Myc-Max heterocomplex to the DNA E-box
- Shows strong inhibitory activity against N-Myc-dependent cell lines
- Partially reverses paclitaxel resistance by reducing MYCN expression
- Can be used for cancer research, including neuroblastoma and thyroid cancer
- Demonstrates high inhibition rates in certain cell types
- Highly stable in liver microsomes
- Regulates MYCN signaling pathway
- Inhibits proliferation, migration, and aggressiveness of cancer cells
Medchemexpress LLC 3-amino-4-{(3S)-3-[(2-ethoxyethoxy)methyl]piperidin-1-yl}thieno[2,3-b]pyridine-2-carboxamide | 2871872-79-4 | 99.9% | C18H26N4O3S | 50 MG
DS96432529 is a potent and orally active bone anabolic agent through CDK8 inhibition.
- Potent bone anabolic agent
- Orally active
- Inhibits CDK8
- For research use only
Medchemexpress LLC Ambroxide | 6790-58-5 | 236.39 | 50 MG
Ambroxide is a naturally occurring terpenoid and a key constituent of ambergris. It is used in the manufacture of high-end perfumes to improve aroma quality and fragrance lasting time.
- Molecular weight: 236.39
- Formula: C16H28O
- CAS No.: 6790-58-5
- Appearance: Solid
- Color: White to off-white
- Structure classification: Terpenoids, other terpenoids
- Initial source: Plants (other families), animals (Physeter catodon L.)
- Purity: 98.0%
- Solubility in vitro: Soluble in DMSO (25 mg/mL)
Medchemexpress LLC PhosTAC7 | 3016307-75-5 | 99.23% | C58H87ClN2O17 | 50 MG
PhosTAC7 is a heterobifunctional molecule, also known as a Phosphorylation Targeting Chimera (PhosTAC). It is designed to dephosphorylate specific proteins by recruiting serine/threonine protein phosphatase 2A (PP2A), making it a valuable tool for various research applications.
- Selectively modulates the phosphorylation state of individual target proteins.
- Dephosphorylates PDCD4, FOXO3a, and tau proteins.
- Useful in research for cancer.
- Applicable in the study of tau protein-related neurodegenerative diseases, such as Alzheimer's.
- For research use only.
Medchemexpress LLC TMX-4100 | 2367619-63-2 | 98.2% | C11H10N4O2S | 100 MG
TMX-4100 is a selective phosphodiesterase 6D (PDE6D) degrader. It demonstrates a high degradation preference for PDE6D with DC50 values less than 200 nM in MOLT4, Jurkat, and MM.1S cells. This compound can be utilized for research into multiple myeloma.
- Demonstrates a high degradation preference for PDE6D in MOLT4 cells.
- Exhibits better proteome-wide degradation selectivity in MOLT4 cells.
- Does not hinder the growth of KRAS-dependent cell lines.
Medchemexpress LLC AST5902 trimesylate | 2929417-90-1 | 98.8% | 842.88 | 50 MG
AST5902 trimesylate is the principal metabolite of Alflutinib (AST2818) both in vitro and in vivo. It exerts antineoplastic activity. Alflutinib is an EGFR inhibitor.
- Principal metabolite of Alflutinib
- Exerts antineoplastic activity
- EGFR inhibitor
- Yellow to orange solid
- Store at 4°C, sealed, away from moisture and light
- In solvent: -80°C for 6 months; -20°C for 1 month
Medchemexpress LLC Su 5214 | 186611-04-1 | MFCD01595259 | >98.0% | 10 MG
SU5214 is a small-molecule tyrosine kinase inhibitor reported to inhibit vascular endothelial growth factor receptor 2 (VEGFR2/FLK-1) and epidermal growth factor receptor (EGFR) in cell-free assays. It is used for biochemical studies and target validation involving VEGFR2/EGFR signaling pathways.
- Reported IC50 of 14.8 μM for VEGFR2 (cell-free assay).
- Reported IC50 of 36.7 μM for EGFR (cell-free assay).
- CAS number 186611-04-1.
- Molecular weight 251.285 g·mol⁻¹.
- Purity greater than 98% (HPLC) as supplied by chemical vendors.
- Supplied in small milligram quantities suitable for in vitro assays.
![Medchemexpress LLC N,N'-1,3-phenylenebis[2,3-dihydroxy-benzamide] | 368449-04-1 | 98.6% | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000232665.png-250.jpg)
Medchemexpress LLC N,N'-1,3-phenylenebis[2,3-dihydroxy-benzamide] | 368449-04-1 | 98.6% | 50 MG
MST-312 (Telomerase Inhibitor IX) is a small-molecule telomerase inhibitor derived from epigallocatechin gallate (EGCG). It is supplied as a white to off-white solid for laboratory research in oncology and telomerase studies.
- Telomerase inhibitor for cancer research.
- Chemically modified derivative of epigallocatechin gallate (EGCG).
- Molecular formula C20H16N2O6 and molecular weight 380.35 g·mol⁻1.
- Purity 98.6%.
- Supplied as a solid with common solubility in DMSO for solution preparation.
Medchemexpress LLC PF-00446687 free base | 862281-92-3 | 98.0% | 470.59 g/mol | C28H36F2N2O2 | 50 MG
PF-00446687 free base is a non-peptide, brain-penetrant small-molecule agonist of the melanocortin-4 receptor (MC4R) used in research on melanocortin signaling and central nervous system pharmacology. It is supplied as a powder for in vitro and in vivo studies and demonstrates low-nanomolar potency and selectivity.
- Selective melanocortin-4 receptor agonist with EC50 12 ± 1 nM.
- Binding affinity (Ki) approximately 27 ± 4 nM.
- Brain-penetrant, suitable for central nervous system studies.
- Provided as a powder with solubility in DMSO 62.5 mg/mL (ultrasonic recommended).
- Molecular formula C28H36F2N2O2 and molecular weight 470.59 g/mol.
- High purity by HPLC (≈98.0% per COA).
- Storage: powder -20°C (long-term) or 4°C (short-term).
Medchemexpress LLC Decanamide, N-[(4-hydroxy-3-methoxyphenyl)methyl]- | 31078-36-1 | 5 MG
N-Vanillyldecanamide is a capsaicinoid isolated from the fruits of Capsicum annuum. It significantly reduced the radical length of Lactuca sativa seedling in a dose-dependent manner. It has a molecular weight of 307.43 and a chemical formula of C18H29NO3. Its appearance is a solid, white to off-white in color. It is for research use only.
- Capsaicinoid isolated from Capsicum annuum
- Significantly reduced radical length of Lactuca sativa seedling
- Molecular weight of 307.43
- Chemical formula of C18H29NO3
- Appears as a white to off-white solid
- For research use only
Medchemexpress LLC Remdesivir metabolite | 1911579-04-8 | 99.6% | C15H19N6O8P | 10MG
GS-704277 is an alanine metabolite of remdesivir used as a research reference standard for antiviral metabolism and analytical studies. It is intended for metabolite identification, pharmacokinetic investigations, and development or validation of chromatographic and mass-spectrometric assays.
- High stated purity suitable for analytical applications.
- Molecular formula and weight provided for confirmation and reporting.
- Available in small research-scale pack sizes for bench studies.
- Useful for metabolite identification and pharmacokinetic work.
- Compatible with LC-MS and HPLC analytical workflows.
Medchemexpress LLC Naz2329 | 2809469-05-2 | 99.0% | 501.56 g/mol | C21H18F3NO4S3 | 25 MG
NAZ2329 is a small-molecule inhibitor of PTPRZ and PTPRG intended for research use. It is supplied as a 25 mg research sample and is characterized by high purity and defined physicochemical properties suitable for biochemical and in vivo studies.
- Inhibits PTPRZ and PTPRG activity.
- High purity: 99.02%.
- Molecular formula: C21H18F3NO4S3; molecular weight: 501.56 g/mol.
- Soluble in DMSO; in vitro solubility reported at 100 mg/mL.
- Provided as a 25 mg sample suitable for preliminary biochemical and in vivo assays.
eMolecules Ambeed / 3-(Bis(benzyloxy)phosphoryl)propanoic acid / 1g / 525098833 / A181500 / / 805243-04-3 / MFCD08064320 / 334.308 / C17H19O5P
Ambeed / 3-(Bis(benzyloxy)phosphoryl)propanoic acid / 1g / 525098833 / A181500 / / 805243-04-3 / MFCD08064320 / 334.308 / C17H19O5P
Medchemexpress LLC Onjisaponin B | 35906-36-6 | 99.1% | 10 MG
Onjisaponin B is a natural triterpenoid saponin isolated from Polygala tenuifolia with reported neuroprotective and autophagy-enhancing activity. It is used in cell-based and preclinical studies investigating protein aggregation, neurodegeneration, and inflammatory signaling.
- Natural triterpenoid saponin derived from Polygala tenuifolia.
- Inhibits NF-κB p65 and modulates inflammatory signaling.
- Enhances autophagy and promotes degradation of mutant α-synuclein and huntingtin.
- High purity solid powder (99.1%).
- Supplied as a 10 mg quantity suitable for research-scale assays.
- Intended for mechanistic studies and preclinical pharmacology models.