Tetrahydrofuran
Sigma Aldrich Fine Chemicals Biosciences Tetrahydrofuran inhibitor-
Tetrahydrofuran (THf) is widely employed as a solvent. It constitutes the key fragment of various natural products (polyether antibiotics). THf forms a double hydrate with hydrogen sulfide. Crystal structure of this double hydrate has been investigated by three-dimensional single-crystal studies. Butane-1 4-diol is formed as an intermediate during the synthesis of THf. Hot THf is useful for the disSOLUTIONon of polyvinylidene chloride (PVDV).
Medchemexpress LLC GSK3182571 | 2135595-04-7 | MFCD28137930 | 99.8% | 495.02 | C25H31ClN8O | 10MG
GSK3182571 is a non-selective, broad-spectrum pan-kinase inhibitor used in research to probe kinase networks and assess off-target effects; it can induce changes in target protein thermostability in cellular assays.
- Pan-kinase inhibitor for kinase network and off-target studies.
- High purity: 99.8%.
- Molecular weight 495.02 g/mol; chemical formula C25H31ClN8O.
- Soluble in DMSO at 100 mg/mL (202.01 mM); use ultrasonication and adjust pH to 4 if required.
- Store powder at -20°C (3 years) or 4°C (2 years); store solutions at -80°C for long-term stability.
- Packaged in small milligram quantities suitable for assay development and biochemical testing.
Medchemexpress LLC Xylobiose | 6860-47-5 | 1 MG
Xylobiose is an orally active Claudin 2/CLDN2 inhibitor and HSP27 inducer that regulates intestinal barrier function and glucose and lipid metabolism. It strengthens intestinal barrier integrity, reduces blood sugar and lipid levels, and mitigates oxidative stress and inflammation. It is used in the study of type 2 diabetes and metabolic syndrome.
- Orally active Claudin 2/CLDN2 inhibitor and HSP27 inducer
- Regulates intestinal barrier function
- Modulates glucose and lipid metabolism
- Reduces intestinal permeability
- Enhances cell protection
- Improves insulin resistance
- Reduces blood sugar and lipid levels
- Decreases oxidative stress and inflammatory response
- Applicable in type 2 diabetes and metabolic syndrome research
Medchemexpress LLC Ambroxide | 6790-58-5 | 236.39 | 100 MG
Ambroxide is a naturally occurring terpenoid, known as a key constituent of ambergris. This compound is widely utilized in the manufacture of high-end perfumes to enhance aroma quality and extend fragrance lasting time.
- Naturally occurring terpenoid
- Key constituent of ambergris
- Utilized in high-end perfumes
- Enhances aroma quality
- Extends fragrance lasting time
- High purity (98.0%)
- Appears as a white to off-white solid
- Molecular formula: C16H28O
Sigma Aldrich Fine Chemicals Biosciences Linalool oxide natural, >=95% | 60047-17-8 | MFCD00053543 |
Linalool oxide natural, >=95% | Purity: >=95% | Mol Wt: 170.25 | 60047-17-8 | MFCD00053543 |
Medchemexpress LLC AZ12601011 | 2748337-86-0 | 99.8% | 100 MG
AZ12601011 is an orally active, selective TGFBR1 (ALK5) kinase inhibitor intended for laboratory research. It inhibits SMAD2 phosphorylation (IC50 = 18 nM; Kd = 2.9 nM), has demonstrated antitumor activity in preclinical models, and is provided with high analytical purity for biochemical assays.
- Selective TGFBR1 inhibition with low-nanomolar potency.
- Inhibits SMAD2 phosphorylation in signaling assays.
- High analytical purity suitable for biochemical studies.
- Supplied as a 100 mg solid for convenient dosing.
- For research use only; not for human or clinical use.
Sigma Aldrich Fine Chemicals Biosciences Tetrahydrofuran suitable for HPLC, >=99.9%, inhibitor-free | 109-99-9 | MFCD00005356 | 4X4L
Tetrahydrofuran suitable for HPLC, >=99.9%, inhibitor-free | Purity: >=99.9% | Mol Wt: 72.11 | 109-99-9 | MFCD00005356 | 4X4L
Medchemexpress LLC Eya2 phosphatase inhibitor | 352336-36-8 | 99.4% | 341.36 g/mol | C17H12FN3O2S | 5 MG
MLS000544460 is a research-grade small molecule that selectively and reversibly inhibits the Eya2 phosphatase. It reduces Eya2-mediated cell migration and has reported anti-cancer activity. The compound is supplied as a powder and as DMSO solutions, is characterized by high purity, and is intended for laboratory research use only.
- Selective, reversible inhibition of Eya2 phosphatase.
- Reported Kd ≈ 2.0 μM and IC50 ≈ 4 μM for target engagement.
- High purity (~99.4%) suitable for biochemical and cell-based assays.
- Available as powder and as ready-to-use DMSO solutions.
- Stable when stored under recommended conditions for research reagents.
- Supplied with datasheet, certificate of analysis, and safety data sheet.
Medchemexpress LLC BDP9066 | 2226507-04-4 | 98.2% | 348.44 | 100 MG
BDP9066 is a potent and selective myotonic dystrophy-related Cdc42-binding kinase (MRCK) inhibitor. It has an IC50 of 64 nM for MRCKβ in SCC12 cells, and Ki values of 0.0136 nM and 0.0233 nM for MRCKα/β respectively (in house determinations). This compound demonstrates a therapeutic effect on skin cancer by reducing substrate phosphorylation.
- Potent and selective MRCK inhibitor.
- Therapeutic effect on skin cancer by reducing substrate phosphorylation.
- Shows antiproliferative effects with greatest activity in hematologic cancer cells.
- Inhibits MLC phosphorylation and blocks SCC12 squamous cell carcinoma motility and invasion.
- Topical application significantly decreases phosphorylated MRCKα S1003 staining and tumor volumes.
![Medchemexpress LLC N-[(E)-[4-(diethylamino)-2-hydroxyphenyl]methylideneamino]pyridine-4-carboxamide | 140405-36-3 | MFCD00542031 | 99.7% | 312.37 g/mol | C17H20N4O2 | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000245949.png-250.jpg)
Medchemexpress LLC N-[(E)-[4-(diethylamino)-2-hydroxyphenyl]methylideneamino]pyridine-4-carboxamide | 140405-36-3 | MFCD00542031 | 99.7% | 312.37 g/mol | C17H20N4O2 | 50 MG
RSVA405 is a small-molecule research compound that potently activates AMP-activated protein kinase (AMPK) and is orally active in vivo. It facilitates CaMKKβ-dependent AMPK activation (EC50 = 1 μM), inhibits mTOR signaling, promotes autophagy and amyloid-β (Aβ) degradation, and shows anti-inflammatory activity via STAT3 inhibition.
- Potent AMPK activator (EC50 = 1 μM).
- Orally active small-molecule research compound.
- Promotes autophagy and increases Aβ degradation.
- Inhibits mTOR signaling and STAT3-mediated inflammation.
- High purity (≈99.7%) light yellow solid.
- Recommended storage: powder -20°C; in solvent -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC 5-(1-methyl-1H-pyrazol-4-yl)-N-(2-methyl-5-(3-(trifluoromethyl)benzamido)phenyl)nicotinamide | 2095849-04-8 | MFCD31813597 | 98.0% | 479.45 g/mol | C25H20F3N5O2 | 50 MG
CSF1R-IN-1 is a potent small-molecule inhibitor of the colony stimulating factor 1 receptor (CSF1R) with a reported IC50 of 0.5 nM. It shows good intestinal permeability in Caco-2 assays and favorable oral pharmacokinetics in mice. The compound is supplied as a solid for research use and includes standard storage recommendations and available solution formulations.
- Potent CSF1R inhibition (IC50 0.5 nM).
- Molecular formula C25H20F3N5O2; molecular weight 479.45 g/mol.
- High purity (98.04%).
- White to off-white solid physical form.
- Stable storage: powder -20°C for up to 3 years; in solvent -80°C for 6 months, -20°C for 1 month.
- Available in multiple sizes and as a 10 mM solution in DMSO.
![Medchemexpress LLC Methyl 3-{[(4-methylphenyl)sulfonyl]amino}benzoate | 173436-66-3 | 99.8% | 100MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000232744.png-250.jpg)
Medchemexpress LLC Methyl 3-{[(4-methylphenyl)sulfonyl]amino}benzoate | 173436-66-3 | 99.8% | 100MG
Methyl 3-{[(4-methylphenyl)sulfonyl]amino}benzoate | 173436-66-3 | 99.8% | 100MG
Medchemexpress LLC Ecliptasaponin D | 206756-04-9 | MFCD30724971 | 99.3% | 634.84 | C36H58O9 | 10 MG
Ecliptasaponin D is a triterpenoid glucoside isolated from Eclipta alba and supplied for research and analytical applications. It is reported to have anti-inflammatory, hepatoprotective, antioxidant, and immunomodulatory activities. Identifiers include CAS 206756-04-9 and molecular formula C36H58O9.
- High purity suitable for analytical and screening assays.
- Characterized molecular weight and formula for reproducibility.
- Supplied in small milligram quantities for compound screening and method development.
- Stable when stored at -20°C and protected from light; in solvent store at -80°C for long-term storage.
- Intended for research use only; not for human or clinical use.
Sigma Aldrich Fine Chemicals Biosciences 2-Methyltetrahydrofuran BioRenewable, ReagentPlus(R), >=99.5%, contains 150-400 ppm BHT as stabilizer | 96-47-9 | MFCD00005367 | 4X4L
2-Methyltetrahydrofuran BioRenewable, ReagentPlus(R), >=99.5%, contains 150-400 ppm BHT as stabilizer | Purity: >=99.5% | Mol Wt: 86.13 | 96-47-9 | MFCD00005367 | 4X4L