Tetrahydrofuran
Medchemexpress LLC Tenuifoliside B | 139726-36-6 | MFCD00915287 | 99.2% | 668.60 g/mol | C30H36O17 | 10 MG
Tenuifoliside B is a natural glycoside isolated from Polygala tenuifolia and supplied as a high-purity solid for laboratory research. It is reported to have neuroprotective and cognition-enhancing effects in preclinical studies and is intended for research use only.
- Natural glycoside isolated from Polygala tenuifolia
- White to yellow solid powder suitable for analytical and biological studies
- Molecular formula C30H36O17 and molecular weight 668.60 g/mol
- High purity (approx. 99.2%) for research applications
- Reported biological activities include inhibition of KCN-induced hypoxia and protection against scopolamine-induced memory impairment
- For research use only; not for human or clinical use
Medchemexpress LLC N-Vanillyldecanamide | 31078-36-1 | MFCD01233545 | 50 MG
N-Vanillyldecanamide is a capsaicinoid isolated from the fruits of Capsicum annuum. It significantly reduced the radical length of Lactuca sativa seedling in a dose-dependent manner. This product is for research use only.
- Purity of 99.86%
- Molecular weight of 307.43
- Molecular formula C18H29NO3
- Appears as a white to off-white solid
- Exhibits agonist activity at rat TRPV1 in CHO cells with an EC50 of 83 nM
Medchemexpress LLC AVJ16 | 2775241-92-2 | 99.6% | C28H27N3O4 | 50 MG
AVJ16 is an inhibitor of insulin-like growth factor 2 mRNA binding protein (IGF2BP1), which shows a strong affinity with a Kd of 1.4 μM. It acts as a cancer cell migration inhibitor by interfering with IGF2BP1's ability to bind target mRNA, thereby regulating gene expression and translation.
- Specifically targets IGF2BP1 with a Kd of 1.4 μM.
- Interferes with IGF2BP1 binding to target mRNA, regulating gene expression and translation.
- Inhibits proliferation, invasion, and migration of IGF2BP1-expressing lung adenocarcinoma cells.
- Suppresses colony formation and spheroid growth, and induces apoptosis in H1299 and LKR-M-FI cells.
- Exhibits antitumor activity in xenograft mouse models.
Medchemexpress LLC ABD957 | 3007772-60-0 | 98.1% | C27H36F3N7O5S | 50 MG
ABD957 is a potent and selective covalent inhibitor of the ABHD17 family of depalmitoylases. This compound can block N-Ras signaling and inhibit the growth of NRAS-mutant AML cells. It is intended for research use only.
- Potent and selective covalent inhibitor of ABHD17 family depalmitoylases
- Blocks N-Ras signaling
- Inhibits the growth of NRAS-mutant AML cells (OCI-AML3, THP1, HL60)
- Attenuates N-Ras depalmitoylation in AML cells at 500 nM
- Has an IC50 of 0.21 μM for ABHD17B
Strem, An Ascensus Company CAS 920-39-8. 0.25mole. i-Propylmagnesium bromide 2.9M (35wt% 1wt%) in 2-methyltetrahydrofuran. MFCD00672110
CAS 920-39-8. 0.25mole. i-Propylmagnesium bromide 2.9M (35wt% 1wt%) in 2-methyltetrahydrofuran. MFCD00672110. Molecular Weight 147.30. Molecular Formula (CH3)2CHMgBr. Color/form liq. Strem 12-0825. http//www.strem.com/catalog/v/12-0825/
Medchemexpress LLC Rhamnocitrin | 569-92-6 | MFCD00006839 | 300.26 | 1 MG
Rhamnocitrin is an anti-inflammatory and antioxidant agent that targets STIM-1, NFATc3, and MAPK pathways. It selectively inhibits oxidative stress and inflammatory responses in vascular endothelial cells and neurons, and is applicable for studying endothelial-related inflammatory diseases and neuroprotection.
- Scavenges DPPH (IC50=28.38 mM).
- Up-regulates miR-185 to inhibit STIM-1-mediated store-operated calcium entry (SOCE).
- Blocks NFATc3 nuclear translocation and downstream inflammatory factor expression.
- Induces heme oxygenase HO-1 expression and regulates the ERK/p38 MAPK pathway.
- Inhibits antioxidant and pro-inflammatory cytokines (e.g., IL-6, IL-8) and adhesion molecules (e.g., ICAM-1, VCAM-1).
Medchemexpress LLC CIL62 | 117593-36-9 | 97.0% | 382.45 | 50 MG
CIL62 is a caspase-3/7-independent cell death inducer that operates via Necrostatin-1 dependent mechanisms. It exhibits antiproliferative activity against human COLO205, IMR32, and K562 cells.
- Caspase-3/7-independent cell death inducer
- Necrostatin-1 dependent mechanism of action
- Antiproliferative activity against COLO205, IMR32, and K562 cells
Medchemexpress LLC 5-(1-methyl-1H-pyrazol-4-yl)-N-(2-methyl-5-(3-(trifluoromethyl)benzamido)phenyl)nicotinamide | 2095849-04-8 | MFCD31813597 | 98.0% | 479.45 g/mol | C25H20F3N5O2 | 50 MG
CSF1R-IN-1 is a potent small-molecule inhibitor of the colony stimulating factor 1 receptor (CSF1R) with a reported IC50 of 0.5 nM. It shows good intestinal permeability in Caco-2 assays and favorable oral pharmacokinetics in mice. The compound is supplied as a solid for research use and includes standard storage recommendations and available solution formulations.
- Potent CSF1R inhibition (IC50 0.5 nM).
- Molecular formula C25H20F3N5O2; molecular weight 479.45 g/mol.
- High purity (98.04%).
- White to off-white solid physical form.
- Stable storage: powder -20°C for up to 3 years; in solvent -80°C for 6 months, -20°C for 1 month.
- Available in multiple sizes and as a 10 mM solution in DMSO.
Medchemexpress LLC Nelonicline | 1026134-63-3 | 99.8% | 313.42 g/mol | C17H19N3OS | 10 MG
Nelonicline is an orally active, selective agonist of the α7 nicotinic acetylcholine receptor supplied as a research reagent for preclinical and in vitro studies. It has molecular formula C17H19N3OS and molecular weight 313.42 g/mol. For research use only; not for clinical or diagnostic applications.
- Selective α7 nicotinic acetylcholine receptor agonist suitable for receptor pharmacology studies.
- Orally active small molecule compatible with in vivo and in vitro experiments.
- Available as a 10 MG solid and as a 10 mM solution in DMSO for assay use.
- High-purity research compound appropriate for preclinical studies.
- Supplied for research use only, not intended for therapeutic use.
Medchemexpress LLC Otaplimastat (SP-8203) | 1176758-04-5 | 98.11% | 534.61 | 50 MG
Otaplimastat (SP-8203) is a matrix metalloproteinase (MMP) inhibitor that competitively blocks N-methyl-D-aspartate (NMDA) receptor-mediated excitotoxicity. It also exhibits anti-oxidant activity and can be used for research on brain ischemic injury.
- MMP inhibitor
- Blocks NMDA receptor-mediated excitotoxicity competitively
- Exhibits anti-oxidant activity
- Potential for research of brain ischemic injury
- Protects neuronal cells against NMDA-induced cell death
- Inhibits Ca2+ influx following activation of NMDA receptors in primary cultured neurons
- Suppresses H2O2-induced cell death and reactive oxygen species production
- Prevents ischemic neuronal death in the occlusion model of MCA in rats
- Attenuates impairment of stroke-induced motor function in rats
Medchemexpress LLC BDP9066 | 2226507-04-4 | 98.18% | 348.44 | 50 MG
BDP9066 is a potent and selective myotonic dystrophy-related Cdc42-binding kinase (MRCK) inhibitor. It inhibits MRCKβ with an IC50 of 64 nM in SCC12 cells and has Ki values of 0.0136 nM for MRCKα and 0.0233 nM for MRCKβ. This compound demonstrates a therapeutic effect on skin cancer by reducing substrate phosphorylation.
- Potent and selective inhibitor of MRCKα and MRCKβ.
- Exhibits antiproliferative effects, particularly in hematologic cancer cells.
- Inhibits MLC phosphorylation and blocks motility and invasion of SCC12 squamous cell carcinoma.
- Topical application significantly decreases phosphorylated MRCKα S1003 staining and tumor volumes.
Medchemexpress LLC Ro5-3335 | 30195-30-3 | 99.35% | 259.69 | 100 MG
Ro5-3335, a benzodiazepine, acts as an inhibitor of core binding factor (CBF) leukemia. It is a RUNX1-CBFβ interaction inhibitor that represses RUNX1/CBFB-dependent transactivation.
- Exhibits antiproliferative activity against human CBF leukemia cell lines.
- Inhibits definitive hematopoiesis in zebrafish embryos.
- Modifies the conformation or increases the distance between the components of the RUNX1-CBFβ complex.
- Identified as an inhibitor of RUNX1-CBFβ function in zebrafish models.
- Rescues preleukemic phenotype in transgenic zebrafish.
- Reduces leukemia burden in a mouse leukemia model.
Medchemexpress LLC Rifalazil 100mg | 129791-92-0 | 100MG
Rifalazil (KRM-1648 ABI-1648) a rifamycin derivative inhibits the bacterial DNA-dependent RNA polymerase and kills bacterial cells by blocking off the -subunit in RNA polymerase[1 Rifalazil (KRM-1648 ABI-1648) is an antibiotic exhibits high potency against mycobacteria gram-positive bacteria Helicobacter pylori C pneumoniae and C trachomatis with MIC values from 0 00025 to 0 0025 g/ml[3 Rifalazil (KRM-1648 ABI-1648) has the potential for the treatment of Chlamydia infection Clostridium difficile associated diarrhea (CDAD) and tuberculosis (TB)[2
Medchemexpress LLC PhosTAC7 | 3016307-75-5 | 99.23% | C58H87ClN2O17 | 50 MG
PhosTAC7 is a heterobifunctional molecule, also known as a Phosphorylation Targeting Chimera (PhosTAC). It is designed to dephosphorylate specific proteins by recruiting serine/threonine protein phosphatase 2A (PP2A), making it a valuable tool for various research applications.
- Selectively modulates the phosphorylation state of individual target proteins.
- Dephosphorylates PDCD4, FOXO3a, and tau proteins.
- Useful in research for cancer.
- Applicable in the study of tau protein-related neurodegenerative diseases, such as Alzheimer's.
- For research use only.
Medchemexpress LLC SR8278 | 1254944-66-5 | 99.9% | C18H19NO3S2 | 50 MG
SR8278 is a REV-ERBα antagonist that inhibits the transcriptional repression activity of REV-ERBα with an EC50 of 0.47 μM. It is utilized to regulate metabolism in organisms, study biological rhythms, and research Duchenne muscular dystrophy and Alzheimer's disease.
- Inhibits REV-ERBα transcriptional repression activity (EC50 of 0.47 μM)
- Regulates metabolism and biological rhythm
- Supports research on Duchenne muscular dystrophy
- Supports research on Alzheimer's disease
- Exerts antidepressant and anxiolytic effects
- Restores circadian rhythm of mood-related behaviors
- Alters REV-ERBα and NURR1 binding activities