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Acyl Halides

Organic compounds that contain a carbon atom bonded to a halogen atom, and an oxygen atom via a double bond; commonly derived from an oxoacid by replacing a hydroxyl group with a halogen atom.
Acyl chlorides (20)
Acyl bromides (1)

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1

Isophthaloyl Chloride 99.0+%, TCI America™

CAS: 99-63-8 Molecular Formula: C8H4Cl2O2 Molecular Weight (g/mol): 203.018 MDL Number: MFCD00000678 InChI Key: FDQSRULYDNDXQB-UHFFFAOYSA-N Synonym: isophthaloyl chloride,isophthaloyl dichloride,1,3-benzenedicarbonyl dichloride,m-phthaloyl chloride,isophthalic chloride,isophthalic acid chloride,isophthalic acid dichloride,isothaloyl chloride,isophthalyl chloride,1,3-benzenedicarbonyl chloride PubChem CID: 7451 IUPAC Name: benzene-1,3-dicarbonyl chloride SMILES: C1=CC(=CC(=C1)C(=O)Cl)C(=O)Cl

PubChem CID 7451
CAS 99-63-8
Molecular Weight (g/mol) 203.018
MDL Number MFCD00000678
SMILES C1=CC(=CC(=C1)C(=O)Cl)C(=O)Cl
Synonym isophthaloyl chloride,isophthaloyl dichloride,1,3-benzenedicarbonyl dichloride,m-phthaloyl chloride,isophthalic chloride,isophthalic acid chloride,isophthalic acid dichloride,isothaloyl chloride,isophthalyl chloride,1,3-benzenedicarbonyl chloride
IUPAC Name benzene-1,3-dicarbonyl chloride
InChI Key FDQSRULYDNDXQB-UHFFFAOYSA-N
Molecular Formula C8H4Cl2O2
2

Medchemexpress LLC NCT-506 | 2231098-99-8 | 99.95% | 478.54 | 1 ML
SDP

NCT-506 is an orally bioavailable aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitor with an IC50 of 7 nM. It is intended for research use only.

  • Inhibits ALDH1A1, hALDH1A3, and hALDH2 with IC50s of 0.007±0.001, 16.4±3.99, and 21.5 μM, respectively.
  • Decreases cell viability with an EC50 of 45.6 μM in OV-90 cells (3D culture) after 6 days.
  • Inhibits MIA PaCa-2, OV-90, and HT-29 cells in aldefluor cell-based assays.
  • Shows enhanced inhibitory effects when combined with Paclitaxel in SKOV-3-TR cells.

ENCOMPASS_PREFERRED
3

Medchemexpress LLC Decanoyl-RVKR-CMK | 150113-99-8 | MFCD00798792 | 98.0% | 744.41 Da | C34H66ClN11O5 | 5 MG
SDP

Decanoyl-RVKR-CMK is a peptide-based proprotein convertase inhibitor used in biochemical and cellular research. It inhibits furin and related convertases, blocking envelope glycoprotein precursor processing and reducing viral replication in cell models. Supplied as a solid for small-scale laboratory studies.

  • Peptide-based inhibitor of furin and proprotein convertases.
  • Blocks envelope glycoprotein precursor processing in cells.
  • Reduces viral replication in cellular assays.
  • Suitable for in vitro biochemical and cell-based studies.
  • Provided as a solid for convenient handling and storage.

ENCOMPASS_PREFERRED
4

Medchemexpress LLC Decanoyl-RVKR-CMK | 150113-99-8 | MFCD00798792 | 98.0% | 744.41 g·mol⁻1 | C34H66ClN11O5 | 1 MG
SDP

Decanoyl-RVKR-CMK is a peptidyl chloromethyl ketone inhibitor of subtilisin/Kex2p-like proprotein convertases (including furin). It is used experimentally to block proprotein convertase activity, inhibit gp160 processing, and reduce viral replication in cell-based and biochemical assays.

  • Peptidyl chloromethyl ketone inhibitor of proprotein convertases.
  • Inhibits gp160 processing and viral replication in experimental systems.
  • Suitable for cell-based and biochemical assays.
  • White to off-white solid supplied in small mass packages.
  • Reported purity about 98.0% and molecular weight 744.41 g·mol⁻1.
  • Used to study furin-dependent protein processing and viral entry.

ENCOMPASS_PREFERRED
5

Apexbio Technology LLC Decanoyl-RVKR-CMK(Synonyms: Dec-RVKR-CMK, Decanoyl-Arg-Val-Lys-Arg-chloromethylketone), 1mg, CAS: 150113-99-8.
SDP

Decanoyl-RVKR-CMK (CAS 150113-99-8) is a small molecule inhibitor targeting proprotein convertases (PCs) enzymes responsible for processing precursor proteins into biologically active peptides and activating various enzymes and growth factors This inhibitor has been observed to suppress regulated secretion and maturation of the neuroendocrine peptide VGF in PC12 cells Additionally topical administration inhibited epidermal proliferation induced by phorbol ester treatment in K5-PACE4 transgenic mice and reduced basal keratinocyte proliferation Decanoyl-RVKR-CMK is relevant in studies investigating PCs as potential targets for therapeutic approaches in cancer and related proliferative disorders

ENCOMPASS_PREFERRED
6

Apexbio Technology LLC Decanoyl-RVKR-CMK(Synonyms: Dec-RVKR-CMK, Decanoyl-Arg-Val-Lys-Arg-chloromethylketone), 500ug, CAS: 150113-99-8.
SDP

Decanoyl-RVKR-CMK (CAS 150113-99-8) is a small molecule inhibitor targeting proprotein convertases (PCs) enzymes responsible for processing precursor proteins into biologically active peptides and activating various enzymes and growth factors This inhibitor has been observed to suppress regulated secretion and maturation of the neuroendocrine peptide VGF in PC12 cells Additionally topical administration inhibited epidermal proliferation induced by phorbol ester treatment in K5-PACE4 transgenic mice and reduced basal keratinocyte proliferation Decanoyl-RVKR-CMK is relevant in studies investigating PCs as potential targets for therapeutic approaches in cancer and related proliferative disorders

ENCOMPASS_PREFERRED
7

Apexbio Technology LLC Decanoyl-RVKR-CMK(Synonyms: Dec-RVKR-CMK, Decanoyl-Arg-Val-Lys-Arg-chloromethylketone), 5mg, CAS: 150113-99-8.
SDP

Decanoyl-RVKR-CMK (CAS 150113-99-8) is a small molecule inhibitor targeting proprotein convertases (PCs) enzymes responsible for processing precursor proteins into biologically active peptides and activating various enzymes and growth factors This inhibitor has been observed to suppress regulated secretion and maturation of the neuroendocrine peptide VGF in PC12 cells Additionally topical administration inhibited epidermal proliferation induced by phorbol ester treatment in K5-PACE4 transgenic mice and reduced basal keratinocyte proliferation Decanoyl-RVKR-CMK is relevant in studies investigating PCs as potential targets for therapeutic approaches in cancer and related proliferative disorders

ENCOMPASS_PREFERRED
8

Sigma Aldrich Oxalyl Chloride

MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.

ENCOMPASS_PREFERRED ENCOMPASS
Boiling Point 62°C to 65°C
Linear Formula ClCOCOCl
CAS 79-37-8
Molecular Weight (g/mol) 126.93 g/mol
MDL Number MFCD00000704
Refractive Index n20/D 1.429
Synonym Ethanedioyl dichloride
Recommended Storage Room Temperature
Molecular Formula C2Cl2O2
EINECS Number 201-200-2
Density 1.5 g/mL at 20°C
Melting Point -10°C to '-8°C
9

Sigma Aldrich Octanoyl chloride

MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.

ENCOMPASS
Boiling Point 195°C (lit.)
Percent Purity 99%
Linear Formula CH3(CH2)6 COCl
CAS 111-64-8
Molecular Weight (g/mol) 162.66
MDL Number MFCD00000766
Refractive Index n20/D 1.435 (literature)
Synonym Capryloyl chloride
RTECS Number RH1570000
Recommended Storage Room Temperature
Molecular Formula C8H15ClO
EINECS Number 203-891-6
Density 0.953 g/mL (at 25°C (literature))
10

Sigma Aldrich Benzoyl Chloride

MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.

ENCOMPASS_PREFERRED ENCOMPASS
Refractive Index n20/D 1.553
RTECS Number DM6600000
Recommended Storage Room Temperature
11

Sigma Aldrich Benzoyl Chloride

MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.

ENCOMPASS_PREFERRED ENCOMPASS
CAS 98-88-4
12

CPC Scientific Decy-Arg-Val-Lys-Arg-CMK (trifluoroacetate salt) 0.5MG
SDP

Peptidyl chloromethylketone that binds to the catalytic site of furin and thus inhibits cleavage and fusion activity of viral glycoproteins, as well as virus replication. This compound also decreases the production of b-amyloid-induced active matrix metalloproteinase 2 in U87 cells. Furthermore, other than furin N-1505 the protein also inhibited the proprotein convertases PC7/LPC, PACE4, and PC6 (W.Garten, personal communication).SEQUENCE: Decy-Arg-Val-Lys-Arg-CMK (trifluoroacetate salt)ONE-LETTER SEQUENCE: Decy-RVKR-CMKMOLECULAR FORMULA: C34H66Cl1N11O5MOLECULAR WEIGHT: 744.4STORAGE CONDITIONS: -20 5 CCAS REGISTRY NUMBER: [150113-99-8]SYNONYMS: Furin Inhibitor I, Dec-RVKR-CMK, Furin Convertase Inhibitor (Chloromethylketone)RESEARCH AREA: ApoptosisREFERENCES:W.Garten et al., Virology, 172, 25 (1989)A.Stieneke-Grber et al., EMBO J., 11, 2407 (1992)S.Hallenberger et al., Nature, 360, 358 (1992)W.Garten et al., Biochimie, 76, 217 (1994)J.-B.Denault et al., FEBS

ENCOMPASS
13

CPC Scientific Decy-Arg-Val-Lys-Arg-CMK (trifluoroacetate salt) 1MG
SDP

Peptidyl chloromethylketone that binds to the catalytic site of furin and thus inhibits cleavage and fusion activity of viral glycoproteins, as well as virus replication. This compound also decreases the production of b-amyloid-induced active matrix metalloproteinase 2 in U87 cells. Furthermore, other than furin N-1505 the protein also inhibited the proprotein convertases PC7/LPC, PACE4, and PC6 (W.Garten, personal communication).SEQUENCE: Decy-Arg-Val-Lys-Arg-CMK (trifluoroacetate salt)ONE-LETTER SEQUENCE: Decy-RVKR-CMKMOLECULAR FORMULA: C34H66Cl1N11O5MOLECULAR WEIGHT: 744.4STORAGE CONDITIONS: -20 5 CCAS REGISTRY NUMBER: [150113-99-8]SYNONYMS: Furin Inhibitor I, Dec-RVKR-CMK, Furin Convertase Inhibitor (Chloromethylketone)RESEARCH AREA: ApoptosisREFERENCES:W.Garten et al., Virology, 172, 25 (1989)A.Stieneke-Grber et al., EMBO J., 11, 2407 (1992)S.Hallenberger et al., Nature, 360, 358 (1992)W.Garten et al., Biochimie, 76, 217 (1994)J.-B.Denault et al., FEBS

ENCOMPASS
14

CPC Scientific Decy-Arg-Val-Lys-Arg-CMK (trifluoroacetate salt) 25MG
SDP

Peptidyl chloromethylketone that binds to the catalytic site of furin and thus inhibits cleavage and fusion activity of viral glycoproteins, as well as virus replication. This compound also decreases the production of b-amyloid-induced active matrix metalloproteinase 2 in U87 cells. Furthermore, other than furin N-1505 the protein also inhibited the proprotein convertases PC7/LPC, PACE4, and PC6 (W.Garten, personal communication).SEQUENCE: Decy-Arg-Val-Lys-Arg-CMK (trifluoroacetate salt)ONE-LETTER SEQUENCE: Decy-RVKR-CMKMOLECULAR FORMULA: C34H66Cl1N11O5MOLECULAR WEIGHT: 744.4STORAGE CONDITIONS: -20 5 CCAS REGISTRY NUMBER: [150113-99-8]SYNONYMS: Furin Inhibitor I, Dec-RVKR-CMK, Furin Convertase Inhibitor (Chloromethylketone)RESEARCH AREA: ApoptosisREFERENCES:W.Garten et al., Virology, 172, 25 (1989)A.Stieneke-Grber et al., EMBO J., 11, 2407 (1992)S.Hallenberger et al., Nature, 360, 358 (1992)W.Garten et al., Biochimie, 76, 217 (1994)J.-B.Denault et al., FEBS

ENCOMPASS
15

CPC Scientific Decy-Arg-Val-Lys-Arg-CMK (trifluoroacetate salt) 5MG
SDP

Peptidyl chloromethylketone that binds to the catalytic site of furin and thus inhibits cleavage and fusion activity of viral glycoproteins, as well as virus replication. This compound also decreases the production of b-amyloid-induced active matrix metalloproteinase 2 in U87 cells. Furthermore, other than furin N-1505 the protein also inhibited the proprotein convertases PC7/LPC, PACE4, and PC6 (W.Garten, personal communication).SEQUENCE: Decy-Arg-Val-Lys-Arg-CMK (trifluoroacetate salt)ONE-LETTER SEQUENCE: Decy-RVKR-CMKMOLECULAR FORMULA: C34H66Cl1N11O5MOLECULAR WEIGHT: 744.4STORAGE CONDITIONS: -20 5 CCAS REGISTRY NUMBER: [150113-99-8]SYNONYMS: Furin Inhibitor I, Dec-RVKR-CMK, Furin Convertase Inhibitor (Chloromethylketone)RESEARCH AREA: ApoptosisREFERENCES:W.Garten et al., Virology, 172, 25 (1989)A.Stieneke-Grber et al., EMBO J., 11, 2407 (1992)S.Hallenberger et al., Nature, 360, 358 (1992)W.Garten et al., Biochimie, 76, 217 (1994)J.-B.Denault et al., FEBS

ENCOMPASS