Benzenoids
Medchemexpress LLC Aapk-25 | 2247919-28-2 | 98.1% | 442.32 | C21H13Cl2N3O2S | 50MG
AAPK-25 is a small-molecule dual inhibitor of Aurora kinases and Polo-like kinases (PLK) that induces mitotic delay and prometaphase arrest, making it useful for cell-based and biochemical studies of mitosis and kinase signaling. Supplied as an off-white to light-yellow solid with high reported purity and available in a 50 mg quantity.
- Dual Aurora and PLK inhibition providing mechanistic relevance for mitotic studies.
- Demonstrated anti-tumor activity in preclinical assays.
- High reported purity (98.09%).
- Available as a 50 mg solid for laboratory experiments.
- Soluble in DMSO; ultrasonication may be required for complete dissolution.
- Stock solutions stable at -80°C for up to 6 months and at -20°C for up to 1 month when protected from light.
Medchemexpress LLC Imifoplatin | 1339960-28-9 | 95.0% | 485.23 | 50 MG
Imifoplatin (PT-112) is a platinum-based active molecule and a member of the phosphaplatins family. Imifoplatin can induce Apoptosis and exhibits antitumor activity.
- Inhibits proliferation in HCT116 cells.
- Induces apoptosis in HCT116 cells.
- Inhibits proliferation in CT26 cells.
- Shows selectivity, strongly inhibiting glycolytic tumor cells with mtDNA mutations.
- Increases mtROS, especially in glycolytic L929dt and Cybrid cells.
- Demonstrates potent antitumor immune effects in the CT26 xenograft model.
- Shows synergistic antitumor effects in the MC38 xenograft model, especially with PD-1 blockade.
Medchemexpress LLC Estropipate | 7280-37-7 | 98.7% | 100 MG
Estropipate is a form of estrogen, used to treat symptoms of menopause, and also used to prevent osteoporosis.
- For research use only. We do not sell to patients.
Medchemexpress LLC Estra-1,3,5(10)-trien-17-one, 3-(sulfooxy)-, compd. with piperazine (1:1) | 7280-37-7 | 98.7% | 500 MG
Estropipate is a form of estrogen that is used to treat symptoms of menopause and to prevent osteoporosis. This product is for research use only.
- Treats symptoms of menopause
- Prevents osteoporosis
- Purity of 98.72%
- Supplied as a white to off-white solid
- Molecular weight of 436.56
- Stable for storage at 4°C, sealed, away from moisture
- Soluble in DMSO (110 mg/mL)
Medchemexpress LLC Estradiol-d4 | 66789-03-5 | 99.6% | 1 MG
Estradiol-d4 is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. It upregulates IL-6 expression through the estrogen receptor beta (ERβ) pathway.
- Used as a tracer
- Functions as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Incorporates stable heavy isotopes of hydrogen, carbon, and other elements
- Deuteration affects the pharmacokinetic and metabolic profiles of drugs
- Applicable in cancer research, metabolic or endocrine disease, and endocrinology
Medchemexpress LLC Borane-protected tris(2-carboxyethyl)phosphine analogue | 188714-28-5 | 99.5% | C14H22BO4P | 10MG
PB1 is a borane-protected tris(2-carboxyethyl)phosphine analogue that serves as a potent intracellular disulfide reducing agent. It exhibits good cell permeability and intracellular stability, and has been reported to improve retinal ganglion cell survival after axotomy in vitro at nanomolar and picomolar concentrations, making it suitable for neuroprotection and intracellular redox studies.
- Potent intracellular disulfide reducing agent.
- Borane-protected tris(2-carboxyethyl)phosphine analogue.
- Good cell permeability and intracellular stability.
- Capable of forming a high intracellular concentration gradient.
- Demonstrated neuroprotective effects in retinal ganglion cell assays at nM and pM ranges.
- Provided as a research-grade powder for biochemical applications.
Medchemexpress LLC 6-(3,4-dichlorobenzamido)-N-(thiazol-2-yl)-2-naphthamide | 2247919-28-2 | 98.1% | 442.32 g/mol | C21H13Cl2N3O2S | 5MG
AAPK-25 is a potent, selective dual inhibitor of Aurora kinases and Polo-like kinases (PLK) used in preclinical research to investigate cell cycle regulation and anticancer mechanisms. It causes mitotic delay and arrests cells in prometaphase, and is provided as a solid or as a DMSO solution for cellular and biochemical assays.
- Potent dual inhibitor of Aurora kinases and PLK.
- Induces mitotic delay and prometaphase arrest in cells.
- Suitable for cellular and biochemical kinase assays.
- High purity (98.1%) for research applications.
- Available in solid and solution formats for flexible use.
- Simple storage guidance for sample stability in solution and solid forms.
eMolecules 2-Cyclohexyl-5-methylphenol | 1596-13-0 | MFCD00142903 | 1g
Combi-Blocks, Inc. | 2-Cyclohexyl-5-methylphenol | 1g | 603146372 | QF-6618 | 95.000 | 1596-13-0 | MFCD00142903 | 190.286 | C13H18O
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Medchemexpress LLC Promestriene | 39219-28-8 | MFCD00867247 | 99.9% | 328.49 | C22H32O2 | 10 MG
Promestriene is a synthetic diethyl ether derivative of estradiol supplied as a solid research reagent. It functions as a locally active estrogen and is used in in vitro and analytical studies of estrogen receptor activity and vaginal atrophy. The material is accompanied by quality documentation for research use only.
- High purity (~99.9%) analytical standard.
- Molecular weight 328.49 g/mol and formula C22H32O2 for accurate calculations.
- Available in small solid quantities, including 10 mg, suitable for lab-scale experiments.
- Supplied with a datasheet and batch information for quality control.
- Intended for research and analytical use; not for clinical or human use.
Medchemexpress LLC (SP-4-2)-diamminetrans-dioxo(tetrahydro-2H-pyran-4,4-diyl)dihydrogen phosphate platinum | 1339960-28-9 | 95.0% | 485.23 | 100 MG
Imifoplatin (PT-112) is a platinum-based active molecule, categorized within the phosphaplatins family. It is known for its ability to induce apoptosis and demonstrates significant antitumor activity. This compound has been investigated for its potential in treating various cancers, showing promising results in both *in vitro* and *in vivo* studies, particularly in inhibiting proliferation and inducing apoptosis in cancer cell lines.
- Induces apoptosis.
- Exhibits antitumor activity.
- Shows dose-dependent proliferation inhibition in cancer cells.
- Significantly increases mitochondrial reactive oxygen species (mtROS).
- Demonstrates potent antitumor immune effects in xenograft models.
- Shows synergistic antitumor effects when combined with immune checkpoint blockers.
Sigma Aldrich Fine Chemicals Biosciences Estrone sulfamate >=98% | 148672-09-7 | MFCD00676965 | 0.2MG
Estrone sulfamate >=98% | Purity: >=98% | Mol Wt: 349.44 | 148672-09-7 | MFCD00676965 | 0.2MG
