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Organic compounds that are derived from or have a benzene group in their molecular structure. Benzene is an aromatic organic molecule composed of 6 carbon atoms and 6 hydrogen atoms that form a ring. Includes derivatives and substituted molecules.
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V-9302 hydrochloride is a competitive antagonist of transmembrane glutamine flux. It selectively and potently targets the amino acid transporter ASCT2 (SLC1A5), but not ASCT1. It inhibits ASCT2-mediated glutamine uptake with an IC50 of 9.6 μM in HEK-293 cells.
Inhibits ASCT2-mediated glutamine uptake in human cells.
Shows improved potency over gamma-L-glutamyl-p-nitroanilide.
Attenuates cancer cell growth and proliferation.
Increases cell death and oxidative stress.
Prevents tumor growth in xenograft models.
Elicits strong growth inhibition in xenograft models when combined with CB-839.
Reduces tumor growth.
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Pritelivir mesylate hydrate, also known as BAY 57-1293 mesylate hydrate, functions as an inhibitor of the viral helicase-primase complex. It demonstrates antiviral activity both in vitro and in animal models against herpes simplex virus (HSV) infection.
Effective against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) with an IC50 of 0.02 μM.
First in class of antiviral agents targeting the viral helicase-primase enzyme complex.
Significantly increases survival in animal models at doses of 0.03-45 mg/kg.
Reduces mortality against HSV-1, E-377 at doses of 0.3-30 mg/kg.
Protective against HSV-2, strain MS, in combination with Acyclovir.
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Varenicline dihydrochloride is a small-molecule partial agonist of neuronal nicotinic acetylcholine receptors, used as a research reagent to study α4β2, α6β2, and α7 receptor pharmacology and mechanisms of nicotine dependence. The dihydrochloride salt improves aqueous solubility for in vitro assays and analytical workflows.
Potent partial agonist of α4β2 nicotinic receptors.
Also active at α6β2 and α7 receptor subtypes.
Suitable for in vitro pharmacology and signaling studies.
High reported purity appropriate for research use.
Dihydrochloride salt enhances solubility in aqueous media.
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IQ-1S free acid is a small-molecule research compound that inhibits NF-κB/AP-1 activity and binds c-Jun N-terminal kinases (JNKs). It is used for cellular and biochemical studies of MAPK/JNK and NF-κB/AP-1 signaling. Molecular formula C15H9N3O, CAS 23146-22-7; molecular weight 247.25.
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