Benzenoids
Medchemexpress LLC Diphenidol hydrochloride | 3254-89-5 | 99.1% | C21H28ClNO | 1 ML
Diphenidol hydrochloride is a non-selective antagonist of muscarinic M1-M4 receptors with anti-arrhythmic activity. It also acts as a potent non-specific blocker of voltage-gated ion channels (Na+, K+, and Ca2+) in neuronal cells, making it suitable for research in antivertigo and antinausea studies.
- Non-selective muscarinic M1-M4 receptor antagonist
- Potent non-specific blocker of voltage-gated Na+, K+, and Ca2+ channels
- Used in antivertigo and antinausea research
- High purity at 99.06%
- Solid, white to off-white appearance
Medchemexpress LLC 2-(2-(benzyloxy)ethoxy)ethyl 4-methylbenzenesulfonate | 98627-22-6 | MFCD28064331 | 98.5% | 350.44 g/mol | C18H22O5S | 500 MG
Benzyl-PEG2-Tos is a benzyl-protected PEG2-based tosylate linker used as a building block in the synthesis of PROTAC (proteolysis targeting chimera) molecules. It provides a short, hydrophilic PEG spacer with a benzyl protecting group and a tosylate leaving group for downstream functionalization.
- short PEG2 spacer for linker assembly
- benzyl protecting group, acid labile
- tosylate functional group for nucleophilic substitution
- molecular weight about 350.4 g/mol
- high purity suitable for research use
- commonly supplied as a 500 mg package
Medchemexpress LLC Bis(2,4,6-trichlorophenyl) oxalate | 1165-91-9 | MFCD00043061 | 98.0% | 448.90 g·mol⁻1 | C14H4Cl6O4 | 5 G
Bis(2,4,6-trichlorophenyl) oxalate is an aryl oxalate reagent supplied for research use. It is provided as a solid at high purity for laboratory applications and is commonly used in chemiluminescent assays and organic synthesis.
- High purity (98.0%).
- Available in small laboratory pack sizes including 5 g.
- Used as a chemiluminescent reagent and in dye synthesis.
- Solid form, typically packaged in a glass bottle.
- CAS number 1165-91-9; molecular formula C14H4Cl6O4; molecular weight 448.90 g·mol⁻1.
Apexbio Technology LLC Safinamide Mesylate 202825-46-5 10mg
Safinamide Mesylate (CAS 202825-46-5) is the mesylate salt form of safinamide a selective and reversible inhibitor of monoamine oxidase B (MAO-B) Safinamide exhibits an IC50 of 98 nM for MAO-B inhibition leading to enhanced dopaminergic transmission by reducing dopamine degradation In addition to MAO-B inhibition safinamide modulates sodium and calcium channels (IC50 8 2 M and 31 5 M respectively) and suppresses glutamate release ( 56 4 M) contributing to its anticonvulsant properties Research applications include the study of Parkinson s disease mechanisms and the investigation of dopaminergic and glutamatergic modulation
Medchemexpress LLC N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide | 262368-30-9 | MFCD12457658 | >=98.0% | C14H22N4O | 50 G
N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide is a chemical compound that acts as a reagent for the preparation of deuterated derivatives of nintedanib. It is used in studies related to angiokinase inhibitory, antitumor activity, and pharmacokinetic properties.
- Reagent for preparation of deuterated derivatives of nintedanib
- Useful in angiokinase inhibitory research
- Applied in antitumor activity studies
- Valuable for pharmacokinetic property investigations
- Solid form
- Off-white to pale beige color
- Melting point of 152-154°C
Apexbio Technology LLC KB-R7943 mesylate 182004-65-5 10mM (in 1mL DMSO)
KB-R7943 mesylate (CAS 182004-65-5) is a selective inhibitor of the Na /Ca2 exchanger (NCX) particularly effective against its reverse mode It inhibits NCX-mediated Ca2 influx with an IC50 of 0 7 M In transfected Chinese hamster ovary (CHO) cells expressing NCX KB-R7943 suppresses exchanger activity at high intracellular Na concentrations In cultured rat forebrain neurons it attenuates Ca2 transients induced by glutamate NMDA kainate or KCl with IC50 values ranging from 2 9 to 8 2 M In in vivo studies KB-R7943 reduces endothelin-1 levels and mitigates acute renal dysfunction following ischemic injury This compound is widely utilized in studies investigating Na /Ca2 exchange and related calcium signaling pathways
Selleck Chemical LLC BIO
BIO (GSK-3 Inhibitor IX 6-bromoindirubin-3-oxime 6-Bromoindirubin-3 -oxime MLS 2052) is a specific inhibitor of GSK-3 with IC50 of 5 nM for GSK-3 / in a cell-free assay shows 16-fold selectivity over CDK5 also a pan-JAK inhibitor with IC50 of 30 nM for Tyk2 BIO induces apoptosis in human melanoma cells
Medchemexpress LLC Omadacycline hydrochloride | 1196800-39-1 | 99.47% | 593.11 | 500 MG
Omadacycline hydrochloride is a first-in-class orally active aminomethylcycline antibacterial, belonging to the tetracycline class of antibiotics. It inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. It exhibits broad-spectrum antibacterial activity against aerobic and anaerobic Gram-positive and Gram-negative bacteria, as well as atypical bacteria. It is used for research on acute bacterial skin and skin-structure infections, community-acquired pneumonia, and urinary tract infections.
- Inhibits bacterial protein synthesis
- Broad-spectrum antibacterial activity
- Active against Gram-positive, Gram-negative, and atypical bacteria
- Effective against MRSA and VRE
- Shows efficacy in mouse systemic infection models
Selleck Chemical LLC Pepstatin A
Pepstatin A (Pepstatin) is a potent aspartic protease inhibitor and also inhibits HIV replication Pepstatin A is also an inhibitor of cathepsins D and cathepsins E Pepstatin A inhibits autophagy by suppressing lysosomal proteases
Selleck Chemical LLC Delavirdine mesylate
Delavirdine Mesylate(U 90152 mesylate) is a mesylate salt form of delavirdine which is a synthetic non-nucleoside reverse transcriptase inhibitor
Selleck Chemical LLC A-1331852
A-1331852 is a potent and selectiveBCL-XL inhibitor with Ki value less than 0 01 nM for BCL-XL and 6 nM 4 nM 142 nM for Bcl-2 Bcl-W MCL-1 respectively It may be useful in the treatment of cancer immune and autoimmune diseases