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Organic compounds that consists entirely of hydrogen and carbon elements usually organized in a chain; some may have a cyclic structure. Includes hydrocarbons that have additional functional groups such as aromatic rings.
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Dynole 2-24 is an indole-based dynamin GTPase inhibitor. It is nontoxic and demonstrates increased potency against dynamin I and II both in vitro and within cells. This compound also exhibits selective inhibition of dynamin I and is an active in-cell inhibitor of clathrin-mediated endocytosis.
Indole-based dynamin GTPase inhibitor.
Has an IC50 of 0.56 μM for dynamin I.
Nontoxic.
Shows increased potency against dynamin I and II in vitro and in cells (IC₅₀(CME)=1.9 μM).
Displays 4.4-fold selectivity for dynamin I.
Functions as an active in-cell inhibitor of clathrin-mediated endocytosis.
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Dynole 2-24 is an indole-based dynamin GTPase inhibitor with an IC₅₀ of 0.56 μM for dynamin I. This compound is non-toxic and demonstrates increased potency against dynamin I and II both in vitro and within cells, with an IC₅₀ (CME) of 1.9 μM. It exhibits a 4.4-fold selectivity for dynamin I. Dynole 2-24 acts as an active in-cell inhibitor of clathrin-mediated endocytosis (CME).
Indole-based dynamin GTPase inhibitor.
IC₅₀ of 0.56 μM for dynamin I.
Nontoxic.
Increased potency against dynamin I and II in vitro and in cells (IC₅₀(CME)=1.9 μM).
Shows 4.4-fold selectivity for dynamin I.
Active in-cell inhibitor of clathrin-mediated endocytosis.
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Dynole 2-24 is an indole-based dynamin GTPase inhibitor with an IC50 of 0.56 μM for dynamin I. It is nontoxic and demonstrates increased potency against dynamin I and II in vitro and in cells (IC₅₀(CME)=1.9 μM). The product also exhibits 4.4-fold selectivity for dynamin I and is an active in-cell inhibitor of clathrin-mediated endocytosis (CME).
Indole-based dynamin GTPase inhibitor
Nontoxic
Increased potency against dynamin I and II in vitro and in cells
4.4-fold selectivity for dynamin I
Active in-cell inhibitor of clathrin-mediated endocytosis (CME)
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Dynole 2-24 is an indole-based dynamin GTPase inhibitor that is non-toxic and demonstrates increased potency against dynamin I and II both in vitro and in cells. It shows selectivity for dynamin I and is an active in-cell inhibitor of clathrin-mediated endocytosis.
Indole-based dynamin GTPase inhibitor
IC50 of 0.56 μM for dynamin I
Non-toxic
Increased potency against dynamin I and II in vitro and in cells
4.4-fold selectivity for dynamin I
Active in-cell inhibitor of clathrin-mediated endocytosis (CME)
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Dynole 2-24 is an indole-based dynamin GTPase inhibitor used as a research reagent to inhibit dynamin I and II and to block clathrin-mediated endocytosis in cells.
Potent inhibitor of dynamin I (IC50 = 0.56 μM).
Active in cells to inhibit clathrin-mediated endocytosis (IC50 ≈ 1.9 μM).
Shows selectivity for dynamin I over dynamin II (≈4.4-fold).
High purity suitable for biochemical and cellular assays.
Available in small research quantities as an oil for convenient handling.
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Dynole 2-24 is an indole-based dynamin GTPase inhibitor used in cell biology research to block dynamin-mediated endocytosis. It exhibits activity against dynamin I and II, is supplied as a high-purity research-grade small molecule, and is soluble in common organic solvents for in vitro assays.
Potent dynamin GTPase inhibition for cellular studies.
High purity appropriate for research use.
Oil form, colorless to light yellow, soluble in DMSO.
Provided in small quantities suitable for screening and mechanistic work.
Applicable to studies of endocytosis and membrane trafficking.
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More