Taniborbactam hydrochloride (VNRX-5133 hydrochloride) is a reversible and selective boronic acid-containing pan-spectrum β-lactamase inhibitor with IC50s of 8-530 nM. It has IC50s of 30 nM, 32 nM, 42 nM, and 20 nM for KPC-2, AmpC, OXA-48, and VIM-2, respectively, and is active against Gram-negative bacteria.
- Reversible and selective boronic acid-containing pan-spectrum β-lactamase inhibitor.
- Effective against KPC-2, AmpC, OXA-48, and VIM-2.
- Active against Gram-negative bacteria.