Organooxygen compounds
Medchemexpress LLC BMY 14802 hydrochloride | 105565-55-7 | MFCD04039786 | 98.0% | 384.85 | C18H23ClF2N4O | 5 MG
BMY-14802 hydrochloride is the hydrochloride salt of a selective and orally active sigma receptor antagonist that also exhibits 5-HT1A agonist and α1-adrenergic activity. It is used in preclinical research exploring antipsychotic effects and movement disorders, and is supplied for research use only.
- Selective sigma receptor antagonist with reported IC50 = 112 nM.
- Also displays 5-HT1A agonist activity and α1-adrenergic effects.
- Supplied for research use only; not for human or veterinary use.
- High purity by HPLC (≈98.0%).
- Available as solid and as a 10 mM solution in DMSO.
- Molecular weight 384.85; formula C18H23ClF2N4O.
Medchemexpress LLC CHK1-IN-4 hydrochloride | 00-00-0 | 480.75 g/mol | C18H19BrClN7O2 | 5 MG
CHK1-IN-4 hydrochloride is the hydrochloride salt of a small-molecule inhibitor of checkpoint kinase 1 (CHK1). It is used in preclinical biochemical and cell-based studies to inhibit CHK1 phosphorylation and evaluate antitumor activity. Supplied as a solid with defined solubility and storage recommendations for research use.
- Potent checkpoint kinase 1 (CHK1) inhibitor active in tumor cells.
- Hydrochloride salt form for improved solubility and handling.
- Solid material; soluble in DMSO at 5 mg/mL with ultrasonic and warming.
- Storage: in solvent -80°C for up to 6 months; sealed -20°C for up to 1 month.
- Supplied in small research pack sizes suitable for preclinical studies.
Medchemexpress LLC Gefitinib hydrochloride | 184475-55-6 | 99.8% | 500 MG
Gefitinib hydrochloride (ZD1839 hydrochloride) is a potent, selective, and orally active inhibitor of EGFR tyrosine kinase, with an IC50 of 33 nM. It specifically inhibits EGF-stimulated tumor cell growth with an IC50 of 54 nM and blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Additionally, Gefitinib hydrochloride has been shown to induce autophagy and possesses antitumour activity.
- Potent, selective, and orally active EGFR tyrosine kinase inhibitor.
- Inhibits EGF-stimulated tumor cell growth.
- Blocks EGF-stimulated EGFR autophosphorylation in tumor cells.
- Induces autophagy.
- Demonstrates antitumour activity.
Medchemexpress LLC Olprinone hydrochloride | 119615-63-3 | 99.9% | C14H11ClN4O | 50 MG
Olprinone Hydrochloride is a potent phosphodiesterase (PDE) 3 inhibitor, showing IC50s of 0.35 μM for PDE3. It is utilized in research for heart failure due to its positive inotropic and vasodilative effects, and also demonstrates anti-inflammatory activity.
- Potent PDE3 inhibitor
- Used in research for heart failure
- Exhibits positive inotropic and vasodilative effects
- Demonstrates anti-inflammatory activity
- Modulates inflammation associated with myocardial ischemia-reperfusion injury
- Reduces pro-inflammatory cytokines such as TNF-α and IL-1β
- Decreases expression of adhesion molecules like ICAM-1 and P-Selectin
- Inhibits apoptosis related to myocardial injury
Medchemexpress LLC Vimirogant hydrochloride | 1802678-42-7 | 98.4% | 552.65 g/mol | C27H35F3N4O3S·xHCl | 1 MG
- Selective RORγt inhibition: Ki = 3.5 nM and IC50 = 17 nM.
- Reduces IL-17A secretion in multiple cell assays (reported IC50 values).
- High purity suitable for research applications (98.39%).
- Solid, light yellow appearance for ease of handling and storage.
- Storage stability: keep at 4°C, sealed and away from moisture; solvent stability specified for -80°C and -20°C.
Medchemexpress LLC Pitolisant hydrochloride | 903576-44-3 | 99.5% | 1 ML
Pitolisant hydrochloride is a research-grade histamine H3 receptor inverse agonist/antagonist supplied as a ready-to-use 10 mM solution in DMSO (1 mL) for in vitro research use. CAS: 903576-44-3.
Medchemexpress LLC Terazosin hydrochloride dihydrate | 70024-40-7 | 99.9% | 50 MG
Terazosin hydrochloride dihydrate is a quinazoline derivative, and it acts as a competitive and orally active α1-adrenoceptor antagonist. It functions by relaxing blood vessels and facilitating the opening of the bladder. This compound shows potential for treating benign prostatic hyperplasia (BPH) and high blood pressure. It is intended for research use only and is not sold to patients.
- Competitively blocks α1-adrenoceptors.
- Can be administered orally.
- Helps in relaxing blood vessels.
- Aids in the opening of the bladder.
- Has potential for the treatment of benign prostatic hyperplasia (BPH) and high blood pressure.
- Suitable for research applications.
Medchemexpress LLC Sultopride hydrochloride | 23694-17-9 | MFCD01319147 | 99.9% | 390.93 | C17H27ClN2O4S | 10 MG
Sultopride hydrochloride (LIN-1418 hydrochloride) is a selective dopamine D2 receptor antagonist supplied as a white to off-white solid for laboratory research applications. It is provided at high reported purity and in small pack sizes for bench-top experiments.
- Selective dopamine D2 receptor antagonist.
- High purity (≈99.9%).
- White to off-white solid physical form.
- CAS number 23694-17-9.
- Molecular weight 390.93 g/mol.
- Available in small pack sizes, including 10 MG.
- Intended for research use only; not for human or clinical use.
- Storage: 4°C, sealed and away from moisture; in solvent: -80°C for 6 months, -20°C for 1 month.
Medchemexpress LLC Tivozanib hydrochloride hydrate | 682745-41-1 | 99.8% | 509.34 | 50 MG
Tivozanib hydrochloride hydrate is the hydrate hydrochloride form of Tivozanib. It is a selective, orally active inhibitor for vascular endothelial growth factor receptor (VEGFR)-1, 2, and 3, with IC50s of 30, 6.5, and 15 nM, respectively. It demonstrates antitumor efficacy.
- Selective, orally active inhibitor for VEGFR-1, 2, and 3
- Exhibits antitumor efficacy
- Inhibits phosphorylation of VEGFR-1, VEGFR-2, and VEGFR-3 with IC50s of 0.16-0.24 nM in vitro
- Inhibits VEGF-induced proliferation and migration of HUVECs in vitro
- Selectively inhibits VEGF-stimulated phosphorylation of MAPKs in endothelial cells in vitro
- Shows antitumor efficacy against breast, colon, hepatic, lung, ovarian, pancreatic, and prostate cancer in athymic mice models in vivo
- Reversibly suppresses vascular permeability and angiogenesis in Calu-6 tumor bearing rats in vivo
eMolecules 29671-92-9 | Chloroformamidine hydrochloride | Chem-Impex | MFCD00035527 | 114.960 | CH4Cl2N2 | 99.000 | Cl.NC(Cl)=N | 5g | 386903866
Chloroformamidine hydrochloride | Chem-Impex | 29671-92-9 | MFCD00035527 | 114.960 | CH4Cl2N2 | 99.000 | Cl.NC(Cl)=N | 5g | 386903866
eMolecules 13071-11-9 | 2R-(+)-Propanolol hydrochloride | Chem-Impex | MFCD00012558 | 295.810 | C16H22ClNO2 | 95.000 | Cl.CC(C)NCC(O)COc1cccc2ccccc12 | 1g | 112446705
2R-(+)-Propanolol hydrochloride | Chem-Impex | 13071-11-9 | MFCD00012558 | 295.810 | C16H22ClNO2 | 95.000 | Cl.CC(C)NCC(O)COc1cccc2ccccc12 | 1g | 112446705
Medchemexpress LLC Trazodone hydrochloride | 25332-39-2 | 99.6% | 100 MG
Trazodone hydrochloride is a triazolopyridine derivative that belongs to the class of serotonin receptor antagonists and reuptake inhibitors (SARIs). It has antidepressant and anti-insomnious activity, exerting antagonistic properties against α1- and α2-adrenergic receptors and histamine H1 receptors with minimal anticholinergic effects.
- Triazolopyridine derivative
- Serotonin receptor antagonist and reuptake inhibitor
- Exhibits antidepressant activity
- Possesses anti-insomnious activity
- Antagonizes α1- and α2-adrenergic receptors
- Antagonizes histamine H1 receptors
- Shows minimal anticholinergic effects
- Demonstrates neuroprotective effects
Medchemexpress LLC Oxyfedrine hydrochloride | 16777-42-7 | 99.9% | 349.85 | C19H24ClNO3 | 10 MG
Oxyfedrine hydrochloride is a vasodilator and an orally active β-adrenoreceptor agonist commonly used in research to investigate cardiovascular function and adrenergic signaling. The compound is supplied as a high-purity hydrochloride salt in small-scale research quantities suitable for biochemical and pharmacological studies.
- High purity suitable for research use.
- Orally active β-adrenoreceptor agonist.
- Available in multiple small-scale package sizes, including 10 mg.
- Stable storage at 4°C in a sealed container away from moisture and light.
- Recommended solvent storage: -80°C for long-term, -20°C for short-term.
- Molecular formula C19H24ClNO3; molecular weight 349.85.
Medchemexpress LLC Noscapine (hydrochloride) | 912-60-7 | 99.9% | 449.88 | 250 MG
Noscapine hydrochloride is an orally active phthalideisoquinoline alkaloid with potent antitussive effects. It activates sigma opioid receptors and inhibits Bradykinin non-competitively. It also disrupts microtubule dynamics, leading to mitotic arrest and apoptosis. This compound exhibits anticancer, neuroprotective, and anti-inflammatory activities, and can cross the blood-brain barrier.
- Activates sigma opioid receptors
- Non-competitive Bradykinin inhibitor
- Disrupts microtubule dynamics
- Induces mitotic arrest and apoptosis
- Exhibits anticancer activity
- Exhibits neuroprotective activity
- Exhibits anti-inflammatory activities
- Capable of crossing the blood-brain barrier