Organooxygen compounds
2-Chloropyridine-4-carboxaldehyde, 97%
CAS: 101066-61-9 Molecular Formula: C6H4ClNO Molecular Weight (g/mol): 141.55 MDL Number: MFCD06651557 InChI Key: UFPOSTQMFOYHJI-UHFFFAOYSA-N Synonym: 2-chloroisonicotinaldehyde,2-chloro-4-pyridinecarboxaldehyde,2-chloro-4-formylpyridine,2-chloro-pyridine-4-carbaldehyde,2-chloropyridine-4-carboxaldehyde,4-pyridinecarboxaldehyde, 2-chloro,pubchem5099,6-chloroisonicotinaldehyde,ksc180g9n,2-chloropyridin-4-carbaldehyde PubChem CID: 2762994 IUPAC Name: 2-chloropyridine-4-carbaldehyde SMILES: ClC1=CC(C=O)=CC=N1
1-Methylcyclopentanol 98.0+%, TCI America™
CAS: 1462-03-9 Molecular Formula: C6H12O Molecular Weight (g/mol): 100.161 MDL Number: MFCD00001364 InChI Key: CAKWRXVKWGUISE-UHFFFAOYSA-N PubChem CID: 73830 IUPAC Name: 1-methylcyclopentan-1-ol SMILES: CC1(CCCC1)O
2-Phenylsulfonylacetophenone 98.0+%, TCI America™
CAS: 3406-03-9 Molecular Formula: C14H12O3S Molecular Weight (g/mol): 260.31 MDL Number: MFCD00025043 InChI Key: DREVPGKOIZVPQV-UHFFFAOYSA-N Synonym: 2-phenylsulfonyl acetophenone,2-phenylsulfonylacetophenone,1-phenyl-2-phenylsulfonyl ethanone,acetophenone, 2-phenylsulfonyl,2-benzenesulfonyl-1-phenylethanone,ethanone, 1-phenyl-2-phenylsulfonyl,1-phenyl-2-phenylsulphonyl ethan-1-one,alpha-phenylsulfonylacetophenone,2-benzenesulfonyl-1-phenylethan-1-one,1-phenyl-2-phenylsulfonyl ethan-1-one PubChem CID: 76949 IUPAC Name: 2-(benzenesulfonyl)-1-phenylethanone SMILES: C1=CC=C(C=C1)C(=O)CS(=O)(=O)C2=CC=CC=C2
2,3-Dimethyl-2-hexanol 99.0+%, TCI America™
CAS: 19550-03-9 Molecular Formula: C8H18O Molecular Weight (g/mol): 130.231 MDL Number: MFCD00021806 InChI Key: BFKOEFFCVFMWPF-UHFFFAOYSA-N PubChem CID: 137270 IUPAC Name: 2,3-dimethylhexan-2-ol SMILES: CCCC(C)C(C)(C)O
1-Phenyl-1-pentanol 98.0+%, TCI America™
CAS: 583-03-9 Molecular Formula: C11H16O Molecular Weight (g/mol): 164.248 MDL Number: MFCD00021935 InChI Key: OVGORFFCBUIFIA-UHFFFAOYSA-N Synonym: fenipentol,1-phenyl-1-pentanol,1-phenylpentanol,pancoral,phenylbutylcarbinol,suiclisin,alpha-butylbenzyl alcohol,1-pentanol, 1-phenyl,1-phenyl-1-hydroxypentane,ph bc PubChem CID: 3338 IUPAC Name: 1-phenylpentan-1-ol SMILES: CCCCC(C1=CC=CC=C1)O
Medchemexpress LLC EPZ004777 hydrochloride | 1380316-03-9 | C28H42ClN7O4 | 50 MG
EPZ004777 hydrochloride is an effective and selective DOT1L inhibitor, reducing H3K79me2 and H3K79me1 levels and down-regulating HOXA9 and MEIS1 expression. This compound selectively inhibits the proliferation of MLL rearrangement cells, promoting their differentiation and apoptosis, making it useful for leukemia research.
- Target: histone methyltransferase; apoptosis
- Pathway: epigenetics; apoptosis
- Potent and selective DOT1L inhibitor (IC50 of 0.4 nM)
- Reduces H3K79me2 and H3K79me1 levels, down-regulating HOXA9 and MEIS1 expression
- Selectively inhibits MLL rearrangement cells, promoting differentiation and apoptosis
- Well tolerated in vivo with no overt toxicity observed
Medchemexpress LLC EPZ004777 hydrochloride | 1380316-03-9 | C28H42ClN7O4 | 1 ML
EPZ004777 hydrochloride is an effective and selective DOT1L inhibitor (IC50 of 0.4 nM). It reduces H3K79me2 and H3K79me1 levels, significantly down-regulating HOXA9 and MEIS1 expression. This compound selectively inhibits the proliferation of MLL rearrangement cells and promotes the differentiation and subsequent apoptosis of leukemia cells, making it suitable for leukemia research.
- Effective and selective DOT1L inhibitor
- Reduces H3K79me2 and H3K79me1 levels
- Significantly down-regulates HOXA9 and MEIS1 expression
- Selectively inhibits proliferation of MLL rearrangement cells
- Promotes differentiation and apoptosis of leukemia cells
Medchemexpress LLC Epz004777 hydrochloride | 1380316-03-9 | C28H42ClN7O4 | 5 MG
EPZ004777 hydrochloride is an effective and selective DOT1L inhibitor with an IC50 of 0.4 nM. It reduces the levels of H3K79me2 and H3K79me1, leading to a significant down-regulation of HOXA9 and MEIS1 expression.
- Selectively inhibits the proliferation of MLL rearrangement cells
- Promotes the differentiation and subsequent apoptosis of leukemia cells
- Can be utilized for leukemia research
- Potent, concentration-dependent inhibition of DOT1L enzyme activity with an IC50 of 400±100 pM
- Remarkable selectivity for DOT1L over other HMTs
Medchemexpress LLC EPZ004777 hydrochloride | 1380316-03-9 | C28H42ClN7O4 | 25 MG
EPZ004777 hydrochloride is an effective and selective DOT1L inhibitor with an IC50 of 0.4 nM. This compound reduces levels of H3K79me2 and H3K79me1, leading to a significant down-regulation of HOXA9 and MEIS1 expression. It selectively inhibits the proliferation of MLL rearrangement cells and promotes the differentiation and subsequent apoptosis of leukemia cells, making it suitable for leukemia research.
- Effective and selective DOT1L inhibitor
- Reduces H3K79me2 and H3K79me1 levels
- Down-regulates HOXA9 and MEIS1 expression
- Selectively inhibits MLL rearrangement cell proliferation
- Promotes differentiation and apoptosis of leukemia cells
- Potent DOT1L enzyme activity inhibition (IC50 of 400±100 pM)
- Demonstrates selectivity over other histone methyltransferases (HMTs)
Sigma Aldrich Fine Chemicals Biosciences 1-Methylcyclopentanol >=99% | 1462-03-9 | MFCD00001364 | 50G
1-Methylcyclopentanol >=99% | Purity: >=99% | Mol Wt: 100.16 | 1462-03-9 | MFCD00001364 | 50G
Medchemexpress LLC EPZ004777 hydrochloride | 1380316-03-9 | 99.5% | 576.13 g·mol⁻¹ | C28H42ClN7O4 | 10 MG
EPZ004777 hydrochloride is a potent, selective inhibitor of the histone methyltransferase DOT1L used in epigenetic and leukemia research. It inhibits DOT1L with an IC50 of 0.4 nM, reduces H3K79 methylation in cells, and has been used to selectively kill MLL-rearranged leukemia cells. This material is supplied for research use only.
- Potent DOT1L inhibition (IC50 0.4 nM).
- Selective activity in biochemical and cellular assays.
- Reduces H3K79 methylation and downregulates leukemogenic gene expression.
- High chemical purity (99.5%).
- Available as solid and as DMSO solution for flexible use in experiments.
- CAS number 1380316-03-9; molecular weight 576.13 g·mol⁻¹.
eMolecules Ambeed / 1-Methylcyclopentanol / 1g / 490511323 / A144549 / / 1462-03-9 / MFCD00001364 / 100.161 / C6H12O
Ambeed / 1-Methylcyclopentanol / 1g / 490511323 / A144549 / / 1462-03-9 / MFCD00001364 / 100.161 / C6H12O