Phenylpropanoids and polyketides
Selleck Chemical LLC Curcumin S1848-1g
Curcumin (Diferuloylmethane Natural Yellow 3 Turmeric yellow) is the principal curcuminoid of the popular Indian spice turmeric which is a member of the ginger family (Zingiberaceae) It is an inhibitor of p300 histone acetylatransferase IC50 25 M and Histone deacetylase (HDAC) activates Nrf2 pathway and supresses the activation of NF- B Curcumin induces mitophagy autophagy apoptosis and cell cycle arrest with antitumor activity Curcumin reduces renal damage associated with rhabdomyolysis by decreasing ferroptosis-mediated cell death Curcumin exhibits anti-infective properties against various human pathogens like the influenza virus hepatitis C virus HIV and so on
![Medchemexpress LLC 2-[(3,4-dihydroxy-5-nitrophenyl)methylidene]propanedinitrile | 116313-73-6 | 98.7% | 231.16 g/mol | C10H5N3O4 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000247989.png-250.jpg)
Medchemexpress LLC 2-[(3,4-dihydroxy-5-nitrophenyl)methylidene]propanedinitrile | 116313-73-6 | 98.7% | 231.16 g/mol | C10H5N3O4 | 25 MG
Tyrphostin AG 1288 is a small-molecule tyrosine kinase inhibitor used in biochemical and cellular research to probe tyrosine kinase-dependent signaling pathways, ICAM1 expression, and TNFα-mediated cytotoxicity. It is supplied as a high-purity research reagent intended for in vitro assays.
- High purity suitable for analytical and cell-based assays.
- Useful for investigating tyrosine kinase signaling pathways.
- Inhibits ICAM1 expression and TNFα-mediated cytotoxicity in vitro.
- Supplied as a stable, solid reagent for easy handling and storage.
- Batch-tested with a certificate of analysis for lot verification.
- Compatible with common solvents for assay formulation.
Medchemexpress LLC Curcumin | 458-37-7 | 98.6% | 10 MM * 1 ML
Curcumin | 458-37-7 | 98.6% | 10 MM * 1 ML
eMolecules 1629972-11-7 | 3-Isobutoxy-4-methoxyphenylboronic acid | Combi-Blocks | MFCD12756417 | 224.060 | C11H17BO4 | 98.000 | COc1ccc(cc1OCC(C)C)B(O)O | 1g | 117524383
3-Isobutoxy-4-methoxyphenylboronic acid | Combi-Blocks | 1629972-11-7 | MFCD12756417 | 224.060 | C11H17BO4 | 98.000 | COc1ccc(cc1OCC(C)C)B(O)O | 1g | 117524383
Medchemexpress LLC Tyrphostin AG1296 | 146535-11-7 | 99.7% | 266.29 | 25 MG
Tyrphostin AG1296 is a potent and selective inhibitor of platelet-derived growth factor receptor (PDGFR), with an IC50 of 0.8 μM. It inhibits signaling of human PDGF α- and β-receptors, as well as the related stem cell factor receptor (c-Kit). This compound is also a potent inhibitor of FLT3, with an IC50 in the micromolar range.
- Potent and selective inhibitor of platelet-derived growth factor receptor (PDGFR)
- Inhibits signaling of human PDGF α- and β-receptors
- Inhibits signaling of the related stem cell factor receptor (c-Kit)
- Potent inhibitor of FLT3
- Suppresses viability of PLX4032-resistant melanoma cells
- Induces apoptosis of A375R cells
- Inhibits PDGFR phosphorylation
- Suppresses A375R tumor growth in vivo
- Inhibits atherosclerotic plaque progression
![Medchemexpress LLC 2-[(3,4-dihydroxy-5-nitrophenyl)methylidene]propanedinitrile | 116313-73-6 | 98.7% | 231.16 g/mol | C10H5N3O4 | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000247968.png-250.jpg)
Medchemexpress LLC 2-[(3,4-dihydroxy-5-nitrophenyl)methylidene]propanedinitrile | 116313-73-6 | 98.7% | 231.16 g/mol | C10H5N3O4 | 10 MG
Tyrphostin AG 1288 is a small-molecule tyrosine kinase inhibitor used in research to block signaling pathways and reduce inflammatory responses, notably by inhibiting ICAM1 expression and TNFα-mediated cytotoxicity in vitro.
- Potent tyrosine kinase inhibitor.
- Inhibits ICAM1 expression and TNFα-mediated cytotoxicity in vitro.
- Molecular formula C10H5N3O4; molecular weight 231.16 g/mol.
- Purity 98.7% as supplied.
- Soluble ≥125 mg/mL (≈540.75 mM) in DMSO.
- Appearance solid, light yellow to yellow.
- Recommended storage: powder -20°C up to 3 years or 4°C up to 2 years; in solution -80°C up to 6 months or -20°C up to 1 month.
Medchemexpress LLC Tyrphostin AG 879 | 148741-30-4 | 99.3% | 316.46 | 1 ML
Tyrphostin AG 879 is a tyrosine kinase inhibitor that inhibits TrKA phosphorylation with an IC50 of 10 μM, but not TrKB and TrKC. It is also a selective ErbB2 tyrosine kinase inhibitor with an IC50 of 1 μM, demonstrating at least 500-fold higher selectivity to ErbB2 than EGFR. Tyrphostin AG 879 exhibits anticancer activity.
- Tyrosine kinase inhibitor.
- Inhibits TrKA phosphorylation (IC50 of 10 μM).
- Selective ErbB2 tyrosine kinase inhibitor (IC50 of 1 μM), with >500-fold selectivity over EGFR.
- Possesses anticancer activity.
- Significantly and dose-dependently decreases cell proliferation in various cell lines (e.g., HL-60, U-937, PC-3) in vitro.
- Induces a dose-dependent increase in apoptosis in several cell lines in vitro.
- Reduces tumor sizes in athymic, immunodepressed NOD/SCID female mice in vivo.
Apexbio Technology LLC Curcumin(Synonyms: Diferuloylmethane, Turmeric yellow, Natural yellow 3, CI 75300), 10mM (in 1mL DMSO), CAS: 458-37-7.
Curcumin (CAS 458-37-7) is a natural small molecule known to inhibit tyrosinase activity with an IC50 of 47 M It modulates multiple signaling pathways involved in tumorigenesis and inflammation influencing transcription factors growth factors cytokines receptors and enzymes Clinical trials at Phase I reported no observed toxicity at doses up to 12 g/day however oral bioavailability is limited ( 1% in Phase I/II studies) Additionally curcumin demonstrates potential for Alzheimer s research as evidenced by reducing beta-amyloid (A 40 A 42) production via downregulating presenilin-1 and GSK-3 in SH-SY5Y neuroblastoma cells
Sigma Aldrich Fine Chemicals Biosciences Curcumin from Curcuma longa (Turmeric), powder | 458-37-7 | MFCD00008365 | 10g
Curcumin from Curcuma longa (Turmeric), powder | Purity: 65% | 368.38 | 458-37-7 | MFCD00008365 | 10g
Chem-Impex International, Inc. Curcumin | 458-37-7 | MFCD00008365 | 25G
Curcumin, 458-37-7, MFCD00008365, 25G