Phenylpropanoids and polyketides
Medchemexpress LLC 7-Hydroxycoumarin-3-carboxylic acid N-succinimidyl ester | 134471-24-2 | >=96.0% | 1 G
7-Hydroxycoumarin-3-carboxylic acid N-succinimidyl ester is the amine-reactive succinimidyl ester of 7-Hydroxycoumarin-3-carboxylic acid. It is a blue fluorescent dye used for labeling proteins and nucleic acids.
- Blue fluorescent dye
- Amine-reactive succinimidyl ester
- Used for labeling proteins and nucleic acids
![Medchemexpress LLC N-[(1S)-1-[3-(4-ethoxyphenyl)-3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-N-(3-pyridinylmethyl | 473720-30-8 | 99.9% | 603.59 g/mol | C32H28F3N5O4 | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000286210.png-250.jpg)
Medchemexpress LLC N-[(1S)-1-[3-(4-ethoxyphenyl)-3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-N-(3-pyridinylmethyl | 473720-30-8 | 99.9% | 603.59 g/mol | C32H28F3N5O4 | 10 MG
AMG 487 (S-enantiomer) is the S enantiomer of AMG 487, a small-molecule antagonist of the CXC chemokine receptor 3 (CXCR3) supplied for research use. The compound is provided as a solid and is characterized by a defined chemical formula, molecular weight, CAS registry number, high purity, and recommended storage conditions.
- S enantiomer of a selective CXCR3 antagonist.
- High purity (99.94%).
- Chemical formula C32H28F3N5O4.
- Molecular weight 603.59 g/mol.
- CAS number 473720-30-8.
- Off-white to light yellow solid appearance.
- Recommended storage: powder -20 °C (3 years) or 4 °C (2 years); in solvent -80 °C (2 years) or -20 °C (1 year).
Apexbio Technology LLC Epothilone B (EPO906, Patupilone)(Synonyms: Patupilone, EPO906, Epothilone B, (-)-Epothilone B, Epothilone B lactam), 10mM (in 1mL DMSO), CAS: 152044-54-7.
Epothilone B (EPO906 Patupilone CAS 152044-54-7) is a naturally occurring macrocyclic lactone initially isolated from the myxobacterium Sorangium cellulosum Sharing a mechanism of action similar to paclitaxel Epothilone B stabilizes microtubules thereby inhibiting cellular mitosis In vitro Epothilone B displays potent cytotoxic activity with an EC0 01 of approximately 1 8 nM Importantly Epothilone B effectively counters resistance mediated via P-glycoprotein which confers paclitaxel resistance and exhibits superior aqueous solubility compared to paclitaxel Research indicates Epothilone B treatment elevates intracellular free calcium and cytosolic cytochrome C in ovarian cancer SKOV-3 cells highlighting its utility as a research tool in cancer biology and chemotherapy resistance studies
Medchemexpress LLC Cinnamyl acetate | 103-54-8 | 100 G
Cinnamyl acetate is a chemical compound widely used in the flavor and fragrance industry. It also functions as a broad-spectrum antibacterial agent. This product is intended for research use only and is not sold to patients.
- Broad-spectrum antibacterial agent
- Suitable for flavor and fragrance applications
- Purity: 99.39%
- Molecular Weight: 176.21
- Chemical formula: C11H12O2
- Appearance: Liquid, colorless to light yellow
- Derived from plants (Liliaceae Allium sativum Linn.)
- Recommended storage for pure form: -20°C for 3 years, 4°C for 2 years
- Recommended storage in solvent: -80°C for 6 months, -20°C for 1 month
- Keep container tightly sealed in cool, well-ventilated area
- Keep away from direct sunlight and sources of ignition
Apexbio Technology LLC Rifabutin 72559-06-9 500mg
Rifabutin is an antimycobacterial agent derived from rifamycin S belonging to the ansamycin antibiotic class It acts by binding to bacterial RNA polymerase inhibiting RNA synthesis and thus suppressing mycobacterial replication Rifabutin exhibits inhibitory activity against Mycobacterium tuberculosis strains with reported minimum inhibitory concentrations (MICs) typically ranging between 0 125 and 0 25 g/ml Due to its bacterial membrane affinity mediated through electrostatic interactions with phospholipid headgroups Rifabutin has attracted research interest in tuberculosis treatment models Experimentally its administration in murine tuberculosis infection models reduced bacterial load in lung liver and spleen tissues It is additionally investigated in clinical contexts particularly to manage tuberculosis infections in immunocompromised hosts including organ transplant recipients
Apexbio Technology LLC Tyrphostin AG 1296 146535-11-7 10mM (in 1mL DMSO)
Tyrphostin AG 1296 (CAS 146535-11-7) is a selective inhibitor of platelet-derived growth factor receptor (PDGFR) kinase via ATP-competitive binding Its inhibitory activity (IC50 0 3 0 5 M) results from inducing conformational changes in the ATP-binding domain of PDGFR blocking receptor autophosphorylation induced by ligand binding In vitro studies demonstrate inhibition of PDGF-stimulated mitogenesis (IC50 1 5 M) and cell proliferation (IC50 3 2 M) using Swiss 3T3 cells without significant effects on EGF receptor signaling at concentrations up to 100 M Tyrphostin AG 1296 serves as a research tool for investigating PDGFR-mediated signaling pathways
Medchemexpress LLC Hesperidin | 520-26-3 | MFCD00075663 | 96.5% | 610.56 g/mol | C28H34O15 | 10 MG
Hesperidin (analytical standard) is a flavanone glycoside isolated from citrus fruits and supplied as a solid reference material for research and analytical applications. It is intended for method development, calibration, and quality control in chromatographic and mass spectrometric assays, and is characterized to support reliable identification and quantitation in analytical workflows.
- Intended for analytical and research use.
- Solid reference material for HPLC and LC-MS workflows.
- Reported purity 96.54%, supporting accurate quantitation.
- Includes standard chemical identifiers (CAS 520-26-3) for traceability.
- Available in small package sizes suitable for analytical laboratories.
Apexbio Technology LLC Doxorubicin (Adriamycin) HCl 25316-40-9 10mM (in 1mL DMSO)
Doxorubicin hydrochloride an anthracycline antibiotic derivative exhibits cytotoxic activity and is widely utilized as an anticancer chemotherapeutic agent Its mechanism involves intercalating into DNA double-strands inhibiting DNA topoisomerase II activity and consequently interrupting replication processes causing DNA damage and altered chromatin structure by histone displacement In biomedical research settings doxorubicin hydrochloride is employed in vitro and in animal models to study therapeutic strategies against hematologic malignancies solid tumors and sarcomas Reported IC50 values vary with cell type and assay conditions typically ranging between approximately 0 1 M to 2 M in various tumor-derived cell models
Apexbio Technology LLC Daidzein 486-66-8 10mM (in 1mL DMSO)
Daidzein is an isoflavone compound derived from soybeans structurally classified as a phytoestrogen with structural similarity to endogenous estrogen It has been widely investigated for its potential in biomedical research particularly in oncology and cell biology studies Daidzein exhibits anticancer-related biological activity possibly via modulation of hormonal signaling pathways and interference with cell cycle progression as exemplified by inducing cell cycle arrest at the G1 phase in cultured mammalian cells Additionally it demonstrates antioxidant properties providing protective effects against oxidative stress-mediated cell injury such as hepatic cellular damage induced by chemical carcinogens Daidzein is thus employed in studies focused on hormone-dependent tumorigenesis cell-cycle regulation mechanisms and oxidative-stress-induced cellular responses
Apexbio Technology LLC (5Z)-7-Oxozeaenol(Synonyms: (5Z)-7-Oxozeaenol, 7-Oxozeaenol, TAK1 inhibitor, MAPKKK inhibitor), 1mg, CAS: 253863-19-3.
(5Z)-7-Oxozeaenol (CAS 253863-19-3) is a naturally occurring resorcylic lactone obtained from fungal sources It functions as a selective inhibitor of transforming growth factor -activated kinase 1 (TAK-1) a member of the mitogen-activated protein kinase kinase kinase (MAPKKK) family In biochemical assays (5Z)-7-Oxozeaenol inhibits purified TAK-1 with an IC50 of approximately 8 1 nM exhibiting minimal activity against related MAPKKKs Cellular studies indicate irreversible blockade of IL-1-stimulated TAK-1 NF- B and JNK/p38 signaling pathways This molecule is useful in inflammation research as demonstrated by its suppression of IL-1-induced COX-2 production and attenuation of inflammatory responses in mouse models