Phenylpropanoids and polyketides
Apexbio Technology LLC (-)-Epigallocatechin gallate (EGCG) 989-51-5 10mM (in 1mL DMSO)
(-)-Epigallocatechin gallate (EGCG CAS 989-51-5) is a major catechin component derived from green tea comprising approximately 59% of total catechins EGCG exhibits antioxidant antiangiogenic antitumor and antiviral properties by modulating cellular signaling pathways involved in apoptosis induction cell cycle arrest and tumorigenesis inhibition It suppresses viral replication in pathogens including HCV HIV-1 HBV HSV-1/2 EBV adenovirus influenza virus and enterovirus and inhibits enzyme targets such as DNA methyltransferases (DNMTs) proteases and DHFR EGCG is utilized widely in biomedical research examining chemoprevention mechanisms and therapeutic potential in cancers such as hepatic gastric dermal pulmonary breast and colorectal malignancies
Sigma Aldrich Fine Chemicals Biosciences Epigallocatechin 3 galla50MG
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity water residual solvents inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH Co. KG
Sigma Aldrich Fine Chemicals Biosciences Rivaroxaban R enantiomer U20MG
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Apexbio Technology LLC Genistein(Synonyms: 4',5,7-Trihydroxyisoflavone, Genisteol, Prunetol, Sophoricol, Differenol A), 10mM (in 1mL DMSO), CAS: 446-72-0.
Genistein (CAS 446-72-0) is an isoflavonoid compound that selectively inhibits protein tyrosine kinases enzymes implicated in signaling pathways associated with oncogenic activity and cellular proliferation Genistein inhibits tyrosine kinase activity with an IC50 of approximately 8 M In NIH-3T3 cell assays genistein suppresses epidermal growth factor (EGF)-mediated mitogenesis (IC50 12 M) and insulin-mediated effects (IC50 19 M) additionally inhibiting EGF-induced activation of S6 kinase at a concentration of 6 15 M In animal models oral administration of genistein demonstrates dose-dependent inhibition of prostate adenocarcinoma development highlighting its utility in cancer biology research and potential chemopreventive applications
Apexbio Technology LLC Daidzein 486-66-8 5g
Daidzein is an isoflavone compound derived from soybeans structurally classified as a phytoestrogen with structural similarity to endogenous estrogen It has been widely investigated for its potential in biomedical research particularly in oncology and cell biology studies Daidzein exhibits anticancer-related biological activity possibly via modulation of hormonal signaling pathways and interference with cell cycle progression as exemplified by inducing cell cycle arrest at the G1 phase in cultured mammalian cells Additionally it demonstrates antioxidant properties providing protective effects against oxidative stress-mediated cell injury such as hepatic cellular damage induced by chemical carcinogens Daidzein is thus employed in studies focused on hormone-dependent tumorigenesis cell-cycle regulation mechanisms and oxidative-stress-induced cellular responses
Medchemexpress LLC Oxytetracycline (dihydrate) | 6153-64-6 | 99.4% | 5 G
Oxytetracycline dihydrate is an antibiotic from the tetracycline class, known for its potent inhibition of Gram-negative and Gram-positive bacteria. It functions as a protein synthesis inhibitor by preventing the binding of aminoacyl-tRNA to the m-ribosomal RNA complex, and also demonstrates anti-HSV-1 activity.
- Antibiotic belonging to the tetracycline class
- Potently inhibits Gram-negative and Gram-positive bacteria
- Acts as a protein synthesis inhibitor
- Prevents binding of aminoacyl-tRNA to m-ribosomal RNA complex
- Exhibits anti-HSV-1 activity
Apexbio Technology LLC Doxorubicin (Adriamycin) HCl 25316-40-9 10mM (in 1mL DMSO)
Doxorubicin hydrochloride an anthracycline antibiotic derivative exhibits cytotoxic activity and is widely utilized as an anticancer chemotherapeutic agent Its mechanism involves intercalating into DNA double-strands inhibiting DNA topoisomerase II activity and consequently interrupting replication processes causing DNA damage and altered chromatin structure by histone displacement In biomedical research settings doxorubicin hydrochloride is employed in vitro and in animal models to study therapeutic strategies against hematologic malignancies solid tumors and sarcomas Reported IC50 values vary with cell type and assay conditions typically ranging between approximately 0 1 M to 2 M in various tumor-derived cell models
Apexbio Technology LLC Tacrolimus monohydrate 109581-93-3 1g
Tacrolimus monohydrate also identified as FK506 monohydrate is a macrolide immunosuppressive compound functioning via inhibition of calcineurin-mediated signaling pathways Specifically tacrolimus forms a complex with FK506-binding protein (FKBP12) subsequently blocking calcineurin phosphatase activity thus suppressing T-cell activation and diminishing interleukin-2 (IL-2) transcription levels In cellular assays tacrolimus demonstrates inhibition of calcineurin with IC50 values typically ranging between 0 1-1 0 nM Due to its targeted modulation of immune signaling this compound remains widely utilized in biomedical research particularly for investigations related to immune response mechanisms autoimmune disorder models transplantation biology and signal transduction pathways relevant to lymphocyte activation and cytokine expression
Apexbio Technology LLC Genistein(Synonyms: 4',5,7-Trihydroxyisoflavone, Genisteol, Prunetol, Sophoricol, Differenol A), 100mg, CAS: 446-72-0.
Genistein (CAS 446-72-0) is an isoflavonoid compound that selectively inhibits protein tyrosine kinases enzymes implicated in signaling pathways associated with oncogenic activity and cellular proliferation Genistein inhibits tyrosine kinase activity with an IC50 of approximately 8 M In NIH-3T3 cell assays genistein suppresses epidermal growth factor (EGF)-mediated mitogenesis (IC50 12 M) and insulin-mediated effects (IC50 19 M) additionally inhibiting EGF-induced activation of S6 kinase at a concentration of 6 15 M In animal models oral administration of genistein demonstrates dose-dependent inhibition of prostate adenocarcinoma development highlighting its utility in cancer biology research and potential chemopreventive applications
Matrix Scientific 2-(3,4-DIHYDROXYPHENYL)-5,7--1
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4h-chromen-4-one Mf C15h10o6 Mw 286.24 Cas 491-70-3 Mdl MFCD00017309
Sigma Aldrich Fine Chemicals Biosciences SIGMA ALDRICH FINE CHEMICALS BIOSCIENCES
NC3894150 ALPHA CYANO 4 HYDROXYCINNAMIC
Sigma Aldrich Fine Chemicals Biosciences Cinnamaldehyde natural 955KG
Cinnamaldehyde is an -unsaturated aromatic aldehyde that can be used as a flavoring agent. It is the principal flavor component of cinnamon oil.
Medchemexpress LLC Genistein 7-sulfate sodium | 99.9% | 372.28 | 1 MG
Genistein 7-sulfate sodium is a metabolite of genistein. It has the ability to reduce the activity of estrogen agonists in MCF-7 cells and can also promote the growth of MCF-7 cells at concentrations of 10 μM and above.
- Metabolite of genistein
- Reduces activity of estrogen agonists in MCF-7 cells
- Promotes growth of MCF-7 cells at concentrations of 10 μM and above
- Used in research on effects on estrogen agonists and MCF-7 cell growth
Apexbio Technology LLC Tyrphostin 9 10537-47-0 25mg
Tyrphostin 9 is a selective inhibitor targeting platelet-derived growth factor receptor (PDGFR) and epidermal growth factor receptor (EGFR) It inhibits PDGFR autophosphorylation with an IC50 of approximately 2 5 M and EGFR kinase activity (IC50 around 460 M) Additionally Tyrphostin 9 inhibits platelet-derived growth factor (PDGF)-stimulated smooth muscle cell proliferation (IC50 approximately 40 nM) as well as phosphorylation of phospholipase C gamma (PLC IC50 2 5 M) and induction of PDGF-dependent c-fos expression In research models Tyrphostin 9 has been utilized to study receptor-mediated signal transduction and vascular injury-related neointimal proliferation processes
Medchemexpress LLC Phenyl salicylate (standard) | 118-55-8 | MFCD00002213 | 99.98% | 50 MG
Phenyl salicylate (Standard) is the analytical standard of Phenyl salicylate. This product is intended for research and analytical applications. Phenyl salicylate (PS) has antibacterial activity when hydrolyzed in the small intestine and is often used as a nervous system inhibitor and intestinal preservative.
- The compound is the grade of analytical standard, which is the reference standard supplied assay.
- It is commonly used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS.