Naratriptan-d3 is a deuterium labeled form of Naratriptan hydrochloride, a selective 5-HT1B/1D receptor agonist. This compound is peripherally active and exhibits good oral bioavailability, inducing cranial artery vasoconstriction. It also inhibits trigeminal nerve-mediated dural neurogenic plasma extravasation and reduces sterile inflammation, making it suitable for research into acute migraine, targeting cranial vascular and neuroinflammatory mechanisms.
- Used as a tracer
- Internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Acts as a selective 5-HT1B/1D receptor agonist
- Exhibits good oral bioavailability
- Induces cranial artery vasoconstriction
- Inhibits trigeminal nerve-mediated dural neurogenic plasma extravasation
- Reduces sterile inflammation