Diterpenoids
Cayman Chemical 10-acetyl Docetaxel 50mg
An inhibitor of ASBT (IC50s 0.53 0.13 and 5.8 nM for the human mouse and canine transporters respectively) selective for ASBT over the hepatic sodium/bile acid cotransporter (IC50 240 nM) induces mild giant migrating contractions in the colon and increases the number of defecations in conscious dogs two hours after administration of 3 10 or 30 mg/kg doses as well as increases the number of defecations after ten hours at 30 mg/kg reduces methionine- and choline-deficient diet-induced increases in serum bile acid levels and hepatic inflammation fibrosis and cytokine gene expression in a mouse model of NASH at 1.2 mg/kg per day
Apexbio Technology LLC Phytol 150-86-7 100g
Phytol is a naturally occurring diterpene alcohol derived from chlorophyll metabolism serving as an activator for retinoid X receptors (RXRs) RXRs are nuclear hormone receptors implicated in transcriptional regulation and cellular differentiation through ligand-dependent signaling pathways involving vitamins and hormones Phytol activates RXRs displaying Ki values ranging from 2 3 to 67 2 M In mammals phytol is metabolized to phytanic acid a reaction regulated by peroxisome proliferator-activated receptor (PPAR ) Additionally phytol interacts with GABA A receptors exhibiting sedative and anxiolytic properties and has been investigated as an antischistosomal candidate in animal models
Apexbio Technology LLC Paclitaxel (Taxol) 33069-62-4 100mg
Paclitaxel (Taxol) is a diterpenoid alkaloid initially isolated from the bark of Taxus brevifolia It exhibits antitumor activity primarily by disrupting microtubule dynamics Mechanistically paclitaxel binds tubulin and promotes microtubule polymerization thus stabilizing microtubules and inhibiting their depolymerization This mechanism impairs normal mitotic spindle formation arrests cells in G2-M phase of the cell cycle and induces apoptotic cell death Paclitaxel is extensively employed in biomedical research for investigating antineoplastic mechanisms and testing therapeutic interventions targeting various cancers such as ovarian breast head and neck and lung carcinoma
Apexbio Technology LLC Paclitaxel (Taxol) 33069-62-4 10mM (in 1mL DMSO)
Paclitaxel (Taxol) is a diterpenoid alkaloid initially isolated from the bark of Taxus brevifolia It exhibits antitumor activity primarily by disrupting microtubule dynamics Mechanistically paclitaxel binds tubulin and promotes microtubule polymerization thus stabilizing microtubules and inhibiting their depolymerization This mechanism impairs normal mitotic spindle formation arrests cells in G2-M phase of the cell cycle and induces apoptotic cell death Paclitaxel is extensively employed in biomedical research for investigating antineoplastic mechanisms and testing therapeutic interventions targeting various cancers such as ovarian breast head and neck and lung carcinoma
Sigma Aldrich Fine Chemicals Biosciences Docetaxel | 114977-28-5 | MFCD00800737 | 5mg
Docetaxel | Purity: 97% | Mol Wt: 807.88 | 114977-28-5 | MFCD00800737 | 5mg
Sigma Aldrich Fine Chemicals Biosciences Aphidicolin from Nigrospor5MG
Aphidicolin from Nigrospor5MG
Microsolv Technology Corporation Direct Adaptive HPLC Column Connector, double end fitting with 0.005" ID x 1/16th" OD, 200mm long stainless steel tubing. 1 EA.
This double end fitting, Direct Adaptive (Di-Ad™) HPLC Column Connector delivers a perfect, zero dead volume connection to any brand of column; minimize the chance of system volume induced band broadening for better chromatography while making it easy and convenient to change columns, between runs. These fittings are easily installed between the injector and the column and between the detector and the outlet side of your column. Then, simply screw the spring loaded end Di-Ad fittings into your column and the tubing pilot length will automatically be adjusted for a tight seal without any void volume. These fittings, with laser cut tubing, replaces the tubing and ordinary male nuts with ferrules or finger tight fittings already in use replacing the need to reset the ferrule swaged on the tubing each time you change column brands. This Di-Ad™ is very convenient for laboratories that use multiple column brands and want to use 0.005" (127um) ID x 200mm (7.87") l
TARGETMOL CHEMICALS INC Paclitaxel 500MG
Also available in 1 g, 1 mL, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Paclitaxel (Taxol) is a natural product and a microtubule polymer stabilizer. Paclitaxel has anti-tumor activity and causes cell death by inducing mitotic arrest, apoptosis, and cell autophagy. Purity 99.92%
TARGETMOL CHEMICALS INC Docetaxel 500MG
Also available in 1 g, 1 mL, 25 mg, 50 mg, 100 mg, 200 mg and bulk. Please contact Fisher for quotes. Docetaxel (RP-56976), a semi-synthetic analog of paclitaxel, is a microtubule depolymerization inhibitor (IC50=0.2 uM) that attenuates the effects of bcl-2 and bcl-xL gene expression and exhibits apoptosis-inducing, anti-tumor activity. Purity 99.1%