Diterpenoids
![Medchemexpress LLC Sodium 1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-2-sulfonate | 69659-80-9 | MFCD09028094 | 99.8% | 396.4 g/mol | C19H17NaO6S | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000295618.png-250.jpg)
Medchemexpress LLC Sodium 1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-2-sulfonate | 69659-80-9 | MFCD09028094 | 99.8% | 396.4 g/mol | C19H17NaO6S | 10 MG
Tanshinone IIA sulfonate sodium is the sodium sulfonate derivative of tanshinone IIA. It is a water-soluble small molecule reported to inhibit store-operated Ca2+ entry (SOCE) and is used in research on cardiovascular disorders and calcium-signaling pathways.
- Water-soluble sodium sulfonate derivative suitable for aqueous assays.
- Reported inhibitor of store-operated Ca2+ entry (SOCE).
- Applicable to cardiovascular and calcium-signaling research models.
- Characterized chemical identifiers: formula C19H17NaO6S and molecular weight 396.4 g/mol.
- High reported purity (≈99.8%) for research applications.
Medchemexpress LLC Isotanshinone IIA | 20958-15-0 | 5 MG
Isotanshinone IIA is an abietane-type diterpene metabolite that non-competitively inhibits Protein Tyrosine Phosphatase 1B (PTP1B) activity with an IC50 of 11.4 μM. Intended for research use only, this product is an orange to orange-red solid with 98.0% purity. It has a molecular weight of 294.34 and a chemical formula of C19H18O3.
- Non-competitive inhibitor of Protein Tyrosine Phosphatase 1B (PTP1B) activity
- IC50 of 11.4 μM
- 98.0% purity
- Appears as an orange to orange-red solid
- Molecular weight of 294.34
- Chemical formula of C19H18O3
- Classified under Quinones and Naphthalene Quinones
- Powder storage: -20°C for 3 years
- In solvent storage: -80°C for 6 months, -20°C for 1 month
- Soluble in DMSO at 3 mg/mL (10.19 mM)
TARGETMOL CHEMICALS INC Tanshinone IIA sulfonate sodiu
Also available in 10 mg, 25 mg, 50 mg, 500 mg and bulk. Please contact Fisher for quotes. Tanshinone IIA sulfonate sodium (Tanshinone IIA sodium sulfonate) is a water-soluble derivative of tanshinone IIA extracted from Savia miltiorrhiza; a potent negative allosteric modulator of the human purinergic receptor P2X7. Tanshinone IIA sulfonate sodium (12.5 uM) inhibits hypoxia-induced PKG and PPAR-gamma downregulation in PASMCs and distal pulmonary arteries of rats. Purity 99.9%
Sigma Aldrich Fine Chemicals Biosciences Cryptotanshinone >=98% (HPLC) | 35825-57-1 | MFCD07636810 | 5MG
Cryptotanshinone >=98% (HPLC) | Purity: >=98% (HPLC) | Mol Wt: 296.36 | 35825-57-1 | MFCD07636810 | 5MG
Cayman Chemical Paclitaxel, Purity: ≥98%, CAS: 33069-62-4, 100 mg
A potent disruptor of microtubules used as a chemotherapeutic compound; inhibits growth of cervical (HeLa), lung (A549), breast (MCF-7), colon (HT-29), ovarian (OVG-1), and pancreatic (PC-Sh) carcinomas with IC50 values ranging from 2.5-7.5 nM; induces mitotic arrest and initiates apoptosis of cancer cells through multiple mechanisms
Apexbio Technology LLC Docetaxel 114977-28-5 10mM (in 1mL DMSO)
Docetaxel (CAS 114977-28-5) is a semisynthetic taxane derivative originally isolated from the European yew (Taxus baccata) As an antineoplastic agent docetaxel disrupts microtubule dynamics by stabilizing tubulin polymerization resulting in cell cycle arrest at mitosis and subsequent apoptosis In both in vitro and in vivo studies docetaxel demonstrates pronounced cytotoxic activity against diverse tumor types such as breast lung ovarian head and neck and gastric cancers Research particularly highlights its enhanced potency against ovarian cancer cell lines compared to paclitaxel cisplatin and etoposide indicating substantial research value in oncology programs
AdipoGen Paclitaxel
Chemical. CAS 33069-62-4. Formula C47H51NO14. MW 853.91. Synthetic. Anticancer compound. Chemotherapeutic used in patients with cancer and advanced forms of Kaposis sarcoma. Microtubule assembly stabilizer. Reversibly binds to polymerized tubulin. Mitotic spindle assembly, chromosome segregation and cell division inhibitor. Induces cell cycle arrest at the G2/M phase. Apoptosis inducer through aberrant activation of cyclin-dependent kinases CKDs and the c-Jun N-terminal kinase/stress activated protein kinase JNK/SAPK. Immunosuppressor, immunostimulant and TRAIL sensitizer.
AdipoGen Docetaxel
Chemical. CAS 114977-28-5. Formula C43H53NO14. MW 807.88. Synthetic. Anticancer agent. Semisynthetic analog of taxol paclitaxel. Inhibits microtubule disassembly and inhibits cell replication. Binds to and stabilizes the beta−tubulin subunit of microtubules, preventing depolymerization of the mitotic spindle thus leading to cell cycle arrest at G2/M and apoptosis. This cytotoxic activity has been widely exploited in suppressing oncogenic proliferation. Displays potent and broad antineoplastic properties, used mainly for the treatment of breast, ovarian, and non-small cell lung cancer. Also inhibits pro-angiogenic factors such as vascular endothelial growth factor VEGF and displays immunomodulatory and pro-inflammatory properties by inducing various mediators of the inflammatory response. Also studied for use as a radiation-sensitizing agent.