Quinone and hydroquinone lipids
Apexbio Technology LLC SCH900776 S-isomer 891494-64-7 5mg
SCH900776 S-isomer is a small-molecule inhibitor targeting checkpoint kinase 1 (Chk1) It is designed to inhibit Chk1 kinase activity thereby interfering with DNA damage-induced checkpoint responses and disrupting S-phase cell-cycle arrest SCH900776 S-isomer exerts its biological activity primarily through selective inhibition of Chk1 kinase (IC50 3 nM) with substantially weaker inhibition toward Chk2 (IC50 1500 nM) and CDK2 (IC50 160 nM) In cellular assays treatment with SCH900776 S-isomer mimics the genetic depletion of CHK1 by RNA interference Based on these pharmacological properties SCH900776 S-isomer holds research potential in oncology particularly in combination with DNA-damaging chemotherapeutics to study enhanced cytotoxicity and altered cell-cycle progression in tumor and leukemia cell lines
Medchemexpress LLC Vitamin K1 (standard) | 84-80-0 | 450.70 | 25 G
Vitamin K1 (standard) | 84-80-0 | 450.70 | 25 G
Cambridge Isotope Laboratories Vitamin B1 hydrochloride (thiamine hydrochloride) (unlabeled) 5 mg
Vitamin B1 hydrochloride (thiamine hydrochloride) (unlabeled) 5 mg
Alkali Scientific Murashige & Skoog Vitamin Mixture, 25.80 Grams of Powder, Makes 250 Milliliters of Solution
Murashige & Skoog Vitamin Mixture is a specially formulated nutrient solution for plant tissue culture. This powder, weighing 25.80 grams, is designed to make 250 milliliters of solution, providing essential vitamins to support healthy growth in plant cells. This mixture is used widely in plant research, supporting the development and maintenance of various plant species in laboratory environments. The solution is critical for supporting physiological functions in tissue cultures, ensuring cell growth, and preventing deficiencies in culture conditions. This product is commonly used in plant biotechnology and other research applications that require a stable environment for plant cells to thrive.
Cambridge Isotope Laboratories Vitamin E succinate (tocopherol succinate) (5-methyl-D3 7-methyl-D3 98%) CP 95% 1 mg
Vitamin E succinate (tocopherol succinate) (5-methyl-D3 7-methyl-D3 98%) CP 95% 1 mg
Selleck Chemical LLC Trolox-100mg
Trolox is a cell-permeable, water-soluble derivative of vitamin E with potent antioxidant properties.
Medchemexpress LLC BMP-4 acetate | 99.3% | 1308.52 (free base) | 5 MG
BMP-4 acetate is a penetrating heparin-binding peptide with anti-inflammatory and anti-chondrogenic functions. It regulates the iNOS-IFN-IL6 signaling pathway to inhibit the expression of inflammatory proteins such as iNOS, COX2, IFN, and IL6, effectively suppressing inflammation and alleviating various arthritis symptoms in murine chondrocytes and macrophages.
- Penetrating heparin-binding peptide
- Anti-inflammatory and anti-chondrogenic functions
- Regulates iNOS-IFN-IL6 signaling pathway
- Inhibits inflammatory proteins like iNOS, COX2, IFN, and IL6
- Alleviates arthritis symptoms in murine chondrocytes and macrophages
![Medchemexpress LLC 2H-Indazole-7-carboxamide, 2-[4-[1-[17-[4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-oxo-1-piperazinyl]-16-oxo-3,6,9,12-tetraoxa-15-azaheptadec-1-yl]-1H-1,2,3-triazol-4-yl]phenyl]- rel- | 99.0% | 1145.09 |...](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000436876-Logo.png-250.jpg){kind=logo}
Medchemexpress LLC 2H-Indazole-7-carboxamide, 2-[4-[1-[17-[4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-oxo-1-piperazinyl]-16-oxo-3,6,9,12-tetraoxa-15-azaheptadec-1-yl]-1H-1,2,3-triazol-4-yl]phenyl]- rel- | 99.0% | 1145.09 |...
rel-PROTAC PARP1 degrader is the relative configuration of ROTAC PARP1 degrader (HY-114324). ROTAC PARP1 degrader is a PARP1 degrader based on MDM2 E3 ligand. It induces significant PARP1 cleavage and programmed cell death. PROTAC PARP1 degrader at 10 μM at 24 h inhibits MDA-MB-231 cell line with an IC50 of 6.12 μM.
- Relative configuration of ROTAC PARP1 degrader
- Based on MDM2 E3 ligand
- Induces significant PARP1 cleavage
- Induces programmed cell death
- Appearance: solid
- Color: white to off-white
- Inhibits MDA-MB-231 cell line with an IC50 of 6.12 μM at 10 μM at 24 h
Medchemexpress LLC Macimorelin acetate | 945212-59-9 | 99.3% | 534.61 | 25 MG
Macimorelin acetate is a GH secretagogue and an orally active GHSR agonist. It stimulates GH release and can be used in research for adult growth hormone deficiency (AGHD) and Cancer anorexia-cachexia syndrome (CACS).
- GH secretagogue
- Orally active GHSR agonist
- Stimulates GH release
- Applicable in research for adult growth hormone deficiency (AGHD)
- Applicable in research for Cancer anorexia-cachexia syndrome (CACS)
- High purity: 99.3%
Alkali Scientific CellPro™ 100X Vitamin solution, 100ml, 10/Case
Growth supplement for cell culture medium. Supplement serum- and protein-free media with CellPro™ 100X Vitamin Solution.
Medchemexpress LLC Poneratoxin acetate | 137084-94-7 | 2756.35 (free base) | 5 MG
Poneratoxin acetate is the acetate salt form of Poneratoxin. It functions as a neurotoxic peptide and modulator for voltage-gated sodium channels (NaV), particularly NaV1.6 and NaV1.7. This compound lowers the voltage threshold for activation, inhibits the inactivation of channels, and enhances neuronal excitability, contributing to the transmission of pain signals.
- Acts as a modulator for voltage-gated sodium channels (NaV)
- EC50 values of 97 nM for NaV1.6 and 2.3 μM for NaV1.7
- Lowers the voltage threshold for activation
- Inhibits the inactivation of channels
- Enhances the excitability of neurons
- Leads to the transmission of pain signals
- Solid with a white color
- For research use only
Medchemexpress LLC Vitamin K1 | 84-80-0 | 98.6% | 450.70 | 500 MG
Vitamin K1 is a naturally occurring vitamin essential for blood coagulation and bone and vascular metabolism. It is a prenylated naphthoquinone synthesized by plants, green algae, and some cyanobacteria, acting as an electron carrier in photosystem I.
- Required for blood coagulation and bone and vascular metabolism in humans
- Shows significant antiproliferative effects and induces apoptosis in Caco-2, HT-29, and SW480 cell lines
- Increased dietary intake is associated with a reduced risk of incident diabetes
- Supplementation reverses high-fat diet-induced bone deterioration
- Topical application suppresses pigmentation and resolves bruising, promoting wound repair
Medchemexpress LLC Rel-PROTAC PARP1 degrader | 99.0% | 1145.09 | 10 MG
rel-PROTAC PARP1 degrader is the relative configuration of ROTAC PARP1 degrader (HY-114324). ROTAC PARP1 degrader is a PARP1 degrader based on MDM2 E3 ligand.
- Induces significant PARP1 cleavage.
- Induces programmed cell death.
- Inhibits MDA-MB-231 cell line with an IC50 of 6.12 μM at 10 μM within 24 hours.
- For research use only.