Formic Acid
Formic acid (HCOOH) is naturally-occurring, flammable, corrosive, organic, and the simplest carboxylic acid. Used as a hydride ion source in synthetic organic chemistry, a mobile phase component in HPLC, a preservative/antibacterial agent in agriculture, etc.
Formic or methanoic acid (CAS: 64-18-6; PubChem ID: 284) is a colorless organic acid with the formula HCOOH. At ambient temperatures, it has a strong, penetrating odor, like acetic acid. Used in chemical synthesis as an intermediate, this simple carboxylic acid is miscible in water and most organic solvents and is somewhat hydrocarbon-soluble.
Formic acid occurs naturally in the venom of some ants and bees. Formate, the conjugate base of formic acid, also occurs naturally in bodily fluids following methanol poisoning.
Formic acid is a source of hydride ion in synthetic organic chemistry, as in the Eschweiler-Clarke and Leuckart-Wallach reactions. It is also a useful component of the mobile phase in reversed-phase high-performance liquid chromatography (RP-HPLC) for peptides, proteins, and intact viruses.
Although formic acid is easily metabolized and eliminated, it can have toxic effects. Methanol metabolism produces formic acid and formaldehyde, which are responsible for the optic nerve damage that results from methanol poisoning. Chronic exposure in humans may cause kidney damage and skin allergies in some people.
In diluted forms, formic acid and formate esters are used as artificial flavorings and perfume additives. In higher concentrations, formic acid is flammable, and skin and eye contact with concentrated liquid or vapors is dangerous.
In agriculture, formic acid is used as a preservative and antibacterial agent and by beekeepers to kill mites. It is useful in leather tanning, textile dyeing and finishing, and in rubber production. Formic acid replaces mineral acids in limescale removers and other cleaning products.
Medchemexpress LLC Ammonium formate | 540-69-2 | MFCD00013103 | 98.5% | 63.06 g/mol | CH5NO2 | 50g
Formic acid ammonium salt is an endogenous metabolite
Medchemexpress LLC 5-Propargyltryptamide formic | 2906227-87-8 | 99.9% | 260.29 g/mol | C14H16N2O3 | 10 MG
5-PT formic (5-Propargyltryptamide formic) is a serotonin-derived chemical probe containing a propargyl (alkyne) moiety for copper-catalyzed azide-alkyne cycloaddition (click chemistry). It is used to label and study protein serotonylation in biochemical and cell-based assays.
- Enables copper-catalyzed click chemistry labeling of serotonylated proteins.
- High chemical purity (99.91%).
- Solid, white to off-white physical form for easy handling and storage.
- Suitable for biochemical and cell-based assay applications.
- Available in small-scale quantities (for example, 10 mg) for exploratory studies.
Medchemexpress LLC CCT367766 (formic) | 98.1% | 992.42 | 100 MG
CCT367766 formic is a potent, third-generation heterobifunctional and Cereblon-based pirin targeting protein degradation probe (PDP, or PROTAC). It depletes pirin protein expression at low concentrations. CCT367766 formic shows a moderate affinity for the CRBN-DDB1 complex with an IC50 value of 490 nM. It also reveals a good affinity for recombinant pirin and CRBN with Kd values of 55 nM and 120 nM, respectively. This compound provides a potential chemical tool to study a largely unexplored protein.
- Depletes pirin protein expression at low concentrations.
- Moderate affinity for CRBN-DDB1 complex with an IC50 value of 490 nM.
- Good affinity for recombinant pirin and CRBN with Kd values of 55 nM and 120 nM.
- Potential chemical tool for studying largely unexplored proteins.
Sigma Aldrich Fine Chemicals Biosciences FORMIC ACID, PURISS. P.A.,2.5L
Formic Acid, puriss. p.a., ACS reagent, reag. Ph. Eur., ≥98% 2.5L
TARGETMOL CHEMICALS INC BMS-561392 FORMIC ACID 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. BMS-561392 Formic acid is a selective inhibitor of TACE and reduces TNFalpha levels.
Medchemexpress LLC SJ1008030 formic | 97.7% | 919.96 | 1 MG
SJ1008030 formic is a JAK2 PROTAC that selectively degrades JAK2. This compound inhibits MHH-CALL-4 cell growth with an IC50 of 5.4 nM and is suitable for leukemia research.
- Selectively degrades JAK2
- Inhibits MHH-CALL-4 cell growth with an IC50 of 5.4 nM
- Can be used for leukemia research
- Purity of 97.7%
- Supplied as a light yellow to yellow solid
- Molecular formula C43H45N13O9S
Medchemexpress LLC PKCiota-IN-2 formic | 99.04% | 402.36 | 50 MG
PKCiota-IN-2 formic is a potent inhibitor of PKCiota (PKC-ι), with an IC50 of 2.8 nM. It also demonstrates inhibitory activity against PKC-α and PKC-ε, exhibiting IC50s of 71 nM and 350 nM, respectively. This product is intended for research use only and is not for sale to patients.
- Potent inhibition of PKCiota.
- Exhibits inhibitory effects on PKC-alpha and PKC-epsilon.
- Available in various quantities, including solid and solution forms.
IMEB, Inc Tek-Select Formic Acid Plus, 32 oz Bottle, This Formula is a Fixative and Decalcifier, Fresh Tissue can be Placed Directly into Formic Acid Plus to Fix and Decalcify Simultaneously
Tek-Select Formic Acid Plus, 32 oz Bottle. This formula is a fixative and decalcifier. Fresh tissue can be placed directly into Formic Acid Plus to fix and decalcify simultaneously.
Sigma Aldrich Fine Chemicals Biosciences Formic acid | 64-18-6 | MFCD00003297 | 500 mL
Formic acid | Purity: 96% | Mol Wt: 46.03 | 64-18-6 | MFCD00003297 | 500 mL
U.S. Pharmacopeia Formic Acid (1.2 mL/ampule; 3 ampules) | 64-18-6 | MFCD00003297
Formic Acid (1.2 mL/ampule; 3 ampules) | Mol Wt: 46.025 | 64-18-6 | MFCD00003297 |
Medchemexpress LLC CCT367766 (formic) | 98.1% | 992.42 | 50 MG
CCT367766 formic is a potent third-generation heterobifunctional and Cereblon-based pirin targeting protein degradation probe. This PROTAC effectively depletes pirin protein expression at low concentrations. It demonstrates a moderate affinity for the CRBN-DDB1 complex with an IC50 of 490 nM. Furthermore, it shows good affinity for recombinant pirin and CRBN, with Kd values of 55 nM and 120 nM, respectively. This product serves as a valuable chemical tool for researching a protein that is currently not well understood.
- Potent third-generation PROTAC.
- Targets pirin protein degradation.
- Moderate affinity for the CRBN-DDB1 complex (IC50 = 490 nM).
- Good affinity for recombinant pirin (Kd = 55 nM) and CRBN (Kd = 120 nM).
- Useful chemical tool for pirin protein studies.